NCT07438496

Brief Summary

The purpose of this study is to evaluate how well nipocalimab works as compared to placebo in participants with moderate to severe Systemic lupus erythematosus (SLE, a long-term disease where the immune system mistakenly attacks its own healthy tissues, causing swelling and redness in various organs).

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
600

participants targeted

Target at P75+ for phase_3

Timeline
64mo left

Started Mar 2026

Longer than P75 for phase_3

Geographic Reach
29 countries

231 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress7%
Mar 2026Nov 2031

First Submitted

Initial submission to the registry

February 23, 2026

Completed
4 days until next milestone

First Posted

Study publicly available on registry

February 27, 2026

Completed
6 days until next milestone

Study Start

First participant enrolled

March 5, 2026

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 6, 2028

Expected
2.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 7, 2031

Last Updated

July 31, 2026

Status Verified

July 1, 2026

Enrollment Period

2.8 years

First QC Date

February 23, 2026

Last Update Submit

July 30, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants Achieving Systemic Lupus Erythematosus (SLE) Responder Index (SRI)-4 Composite Response at Week 52

    SLE SRI-4 composite response is a composite response of at least a 4 point reduction in SLE Disease Activity Index 2000 (SLEDAI-2K), no British Isles Lupus Assessment Group-2004 (BILAG-2004) worsening, defined as no new A or less than or equal to \<= 1 new B items compared to baseline, no worsening in Physician's Global Assessment (PGA \[greater than {\>} 10 percent {%} increase from baseline\]).

    Week 52

Secondary Outcomes (9)

  • Percentage of Participants Achieving SRI-4 Composite Response at Week 52 with High Baseline IFN Gene Signature (Interferon [IFN] high)

    Week 52

  • Percentage of Participants Achieving SRI-4 Composite Response at Week 52 with Sustained Reduction in Oral Glucocorticoid (GC) Dose

    Week 52

  • Percentage of Participants Who Achieve Lupus Low Disease Activity State (LLDAS) At Week 52

    Week 52

  • Percentage of Participants with < 2 Active Joints at Week 52 in Participants with >= 2 Active Joints at Baseline

    Week 52

  • Change From Baseline in Lupus Symptoms Joint Pain Score at Week 52

    Baseline, Week 52

  • +4 more secondary outcomes

Study Arms (2)

Nipocalimab

EXPERIMENTAL

Participants will receive nipocalimab up to Week 52 in the double blind treatment period along with standard of care treatments. At Week 52, eligible participants from both studies will have the option to enter an open-label long-term extension (OLE) period, where they will continue to receive nipocalimab until Week 156 or until the study intervention is discontinued.

Drug: NipocalimabDrug: Standard of care treatment

Placebo

PLACEBO COMPARATOR

Participants will receive placebo up to Week 52 in the double blind treatment period along with standard of care treatment. At Week 52, eligible participants from both studies will have the option to enter an OLE period, where they will continue to receive nipocalimab until Week 156 or until the study intervention is discontinued.

Drug: NipocalimabDrug: PlaceboDrug: Standard of care treatment

Interventions

Nipocalimab will be administered.

NipocalimabPlacebo

Placebo will be administered.

Placebo

Protocol-defined topical and systemic standard of care background treatments.

NipocalimabPlacebo

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Medically stable on the basis of physical examination, medical history, vital signs and 12-lead electrocardiogram (ECG) performed at screening
  • Clinical diagnosis of systemic lupus erythematosus (SLE) for more than or equal to (\>=) 24 weeks prior to screening and meeting european league against rheumatism/american college of rheumatology (EULAR/ACR) classification criteria
  • Must have a systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) score \>= 6 and a clinical SLEDAI-2K \>= 4 at screening, AND a clinical SLEDAI-2K score \>= 4 points at Week 0. For eligibility, points attributed to "lupus headache," "alopecia," and "organic brain syndrome" are excluded
  • Participants of childbearing potential must have a negative serum beta human chorionic gonadotropin (β-hCG) test at screening and a negative urine (β- hCG) test at Week 0 prior to randomization
  • Has at least 1 BILAG-2004 A score or 2 BILAG-2004 B scores observed at screening

You may not qualify if:

  • History of severe, progressive and/or uncontrolled hepatic, gastrointestinal, renal, pulmonary, cardiovascular, psychiatric, neurological or musculoskeletal disorder, hypertension, and/or any other medical or uncontrolled autoimmune disorder (s) or clinically significant abnormalities in screening laboratory
  • Any unstable or progressive manifestation of SLE that is likely to warrant escalation in therapy beyond permitted background medications
  • Confirmed or suspected clinical immunodeficiency syndrome not related to treatment of SLE or has a family history of congenital or hereditary immunodeficiency unless confirmed absent in the participant
  • Has shown a previous severe immediate hypersensitivity reaction, such as anaphylaxis, to therapeutic proteins
  • Suspected or known allergies, hypersensitivity, or intolerance to nipocalimab or its excipients, or excipients used in the placebo formulation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (231)

David S Hallegua MD A Professional Corporation

Beverly Hills, California, 90211, United States

RECRUITING

Providence Medical Foundation

Fullerton, California, 92835, United States

RECRUITING

Southland Arthritis and Osteoporosis Medical Center Inc dba Southland Arthritis

Hemet, California, 92543, United States

RECRUITING

Advanced Medical Research

La Palma, California, 90623, United States

RECRUITING

Medvin Clinical Research San Leandro

San Leandro, California, 94578, United States

RECRUITING

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Torrance, California, 90502, United States

RECRUITING

Solace Clinical Research California

Tustin, California, 92780, United States

RECRUITING

Inland Rheumatology Clinical Trials Inc.

Upland, California, 91786, United States

RECRUITING

Arthritis & Rheumatic Disease Specialties

Aventura, Florida, 33180, United States

RECRUITING

Clinical Research of West Florida 1

Clearwater, Florida, 33765, United States

RECRUITING

Avanti Clinical Research Corp

Hialeah, Florida, 33013, United States

RECRUITING

LeJenue Research Associates PLLC

Miami, Florida, 33126, United States

RECRUITING

Pro-Care Research Center, Corp.

Miami Gardens, Florida, 33014, United States

RECRUITING

Floridian Clinical Research LLC

Miami Lakes, Florida, 33016, United States

RECRUITING

Integral Rheumatology And Immunology Specialists

Plantation, Florida, 33324, United States

RECRUITING

Clinical Research of West Florida

Tampa, Florida, 33606, United States

RECRUITING

Atlanta Research Center for Rheumatology

Marietta, Georgia, 30060, United States

RECRUITING

Willow Rheumatology and Wellness PLLC

Willowbrook, Illinois, 60527, United States

RECRUITING

Accurate Clinical Research, Inc.

Lake Charles, Louisiana, 70605, United States

RECRUITING

Revive Research Institute

Sterling Heights, Michigan, 48313, United States

RECRUITING

Arthritis Rheumatic And Back Disease Associates

Voorhees Township, New Jersey, 08043, United States

RECRUITING

Joint and Muscle Research Institute

Charlotte, North Carolina, 28204, United States

RECRUITING

DJL Clinical Research, PLLC

Charlotte, North Carolina, 28211, United States

RECRUITING

Cross Creek Medical Clinic

Fayetteville, North Carolina, 28304 4422, United States

RECRUITING

Paramount Medical Research & Consulting

Middleburg Heights, Ohio, 44130, United States

RECRUITING

Clinical Research Philadelphia

Philadelphia, Pennsylvania, 19114, United States

RECRUITING

West Tennessee Research Institute

Jackson, Tennessee, 38305, United States

RECRUITING

Amarillo Center for Clinical Research

Amarillo, Texas, 79124, United States

RECRUITING

Arthritis and Rheumatology Research Institute

Frisco, Texas, 75035, United States

RECRUITING

R and H Clinical Research

Katy, Texas, 77449, United States

RECRUITING

Southwest Rheumatology Research LLC

Mesquite, Texas, 75150, United States

RECRUITING

Texas Rheumatology Research Institute LLC

Plano, Texas, 75024, United States

RECRUITING

Epic Medical Research 1

Red Oak, Texas, 75154, United States

RECRUITING

Fort Bend Rheumatology Associates PLLC

Sugar Land, Texas, 77479, United States

RECRUITING

Carilion Clinic Virginia Tech Carilion School of Medicine

Roanoke, Virginia, 24011, United States

RECRUITING

ARCIS Salud SRL Aprillus asistencia e investigacion

Buenos Aires, C1406AGA, Argentina

RECRUITING

Centro Privado de Medicina Familiar

Buenos Aires, C1417EYG, Argentina

RECRUITING

Hospital Central Militar Cirujano Mayor Dr Cosme Argerich

CABA, C1426BOS, Argentina

RECRUITING

Centro de Investigacion en Enfermedades Reumaticas CIER

Ciudad de Buenos Aires, C1055, Argentina

RECRUITING

Arsema

Ciudad de Buenos Aires, C1427, Argentina

RECRUITING

Global Psy Asociacion Civil

La Plata, B1904, Argentina

RECRUITING

Cer Instituto Medico

Quilmes, B1878DVB, Argentina

RECRUITING

Instituto de Investigaciones Clinicas Quilmes

Quilmes, B1878GEG, Argentina

RECRUITING

Sanatorio de la Mujer

Rosario, 2000, Argentina

RECRUITING

MR Medicina Reumatologica

San Fernando, B1646GHP, Argentina

RECRUITING

Centro de Investigaciones Medicas Tucuman

San Miguel de Tucumán, T4000AXL, Argentina

RECRUITING

BOX HILL

Box Hill, 3128, Australia

RECRUITING

Footscray Hospital, Western Health

Footscray, 3011, Australia

RECRUITING

Ipswich Hospital

Ipswich, 4305, Australia

RECRUITING

Hospital das Clinicas - UFG

Goiânia, 74605-020, Brazil

RECRUITING

CMIP - Centro Mineiro de Pesquisa Ltda

Juiz de Fora, 36010 570, Brazil

RECRUITING

Hospital De Clinicas De Porto Alegre

Porto Alegre, 90035-903, Brazil

RECRUITING

LMK Servicos Medicos S S

Porto Alegre, 90480 000, Brazil

RECRUITING

Associacao Hospitalar Moinhos de Vento

Porto Alegre, 90560032, Brazil

RECRUITING

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS

Porto Alegre, 90610 000, Brazil

RECRUITING

Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto

Ribeirão Preto, 14051140, Brazil

RECRUITING

SER - Servicos Especializados em Reumatologia da Bahia

Salvador, 40150 150, Brazil

RECRUITING

Fundacao do ABC Centro Universitario FMABC

Santo André, 09060 870, Brazil

RECRUITING

Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base

São José do Rio Preto, 15090 000, Brazil

RECRUITING

ESHO Empresa De Servicos Hospitalares S A

São Paulo, 01232 010, Brazil

RECRUITING

CEDOES Centro de Pesquisa Clinica e Diagnostico do Espirito Santo Ltda

Vitória, 29055 450, Brazil

RECRUITING

MC Medtech Services Ltd

Haskovo, 6304, Bulgaria

RECRUITING

Multiprofile Hosptal for Active Treatment Eurohospital Plovdiv

Plovdiv, 4004, Bulgaria

RECRUITING

Diagnostic consulting center 1 Ruse EOOD

Rousse, 7002, Bulgaria

RECRUITING

Diagnostic-Consultative Center (DCC) Aleksandrovska

Sofia, 1431, Bulgaria

RECRUITING

Medical Center Hera EOOD

Sofia, 1510, Bulgaria

RECRUITING

Military Medical Academy Multiprofile Hospital for Active Treatment Sofia

Sofia, 1606, Bulgaria

RECRUITING

UMHAT 'Sveti Ivan Rilsky'

Sofia, 1612, Bulgaria

RECRUITING

University Multi Profile Hospital for Active Treatment UMHAT St. Marina

Varna, 9010, Bulgaria

RECRUITING

Peking University People's Hospital

Beijing, 100044, China

RECRUITING

West China School of Medicine/West China Hospital, Sichuan University

Cheng Du Shi, 610041, China

RECRUITING

Dongguan People s Hospital

Dongguan, 523109, China

RECRUITING

The First Affiliated Hospital Sun Yat-Sen University

Guangzhou, 510080, China

RECRUITING

The Second Affiliated Hospital of Zhejiang University College of Medicine

Hangzhou, 311608, China

RECRUITING

Anhui Provincial Hospital

Hefei, 230061, China

RECRUITING

Jinhua municipal central hospital

Jinhua, 321013, China

RECRUITING

Shandong Jining No.1 People's Hospital

Jining, 272073, China

RECRUITING

Linfen Central Hospital

Linfen, 041000, China

RECRUITING

The first affiliated hospital of Henan University of science and technology

Luoyang, 471003, China

RECRUITING

The Second Affiliated Hospital of Nanchang University

Nanchang, 330008, China

RECRUITING

Nanjing Drum Tower Hospital

Nanjing, 210009, China

RECRUITING

Ningbo medical center lihuili hospital

Ningbo, 315041, China

RECRUITING

Renji Hospital, Shanghai Jiaotong University School of Medicine

Shanghai, 200001, China

RECRUITING

Shenshan Medical Center Memorial Hospital of Sun Yat Sen University

Shanwei, 516601, China

RECRUITING

Second Affiliated Hospital, SooChow University

Suzhou, 215004, China

RECRUITING

Shanxi Bethune Hospital

Taiyuan, 030032, China

RECRUITING

Xinxiang Central Hospital

Xinxiang, 453099, China

RECRUITING

Fakultní nemocnice u sv. Anny v Brn

Brno, 602 00, Czechia

RECRUITING

Revimex Pro s r o

Karvina Frystat, 733 01, Czechia

RECRUITING

Revmatologicky ustav

Prague, 128 50, Czechia

RECRUITING

Rigshospitalet

Copenhagen, 2100, Denmark

RECRUITING

Zealand University Hospital

Køge, 4600, Denmark

RECRUITING

Helsinki University Hospital

Helsinki, 00290, Finland

RECRUITING

Northern Clinical Trial Coordinators

Oulu, 90150, Finland

RECRUITING

Turku University Hospital

Turku, 20520, Finland

RECRUITING

CHU de Caen

Caen, 14000, France

RECRUITING

Hopital Michallon CHU Grenoble Alpes

La Tronche, 38700, France

RECRUITING

Centre Hospitalier Le Mans

Le Mans, 72037, France

RECRUITING

Hospices Civils de Lyon - HOPITAL DE LA CROIX ROUSSE

Lyon, 69004, France

RECRUITING

Hopital Cochin

Paris, 75014, France

RECRUITING

CHU Toulouse - Hopital de Rangueil

Toulouse, 31400, France

RECRUITING

Universitätsklinikum Carl-Gustav-Carus Dresden

Dresden, 01307, Germany

RECRUITING

CAIR Heidelberg

Heidelberg, 69121, Germany

RECRUITING

Universitaetsklinikum Leipzig

Leipzig, 04103, Germany

RECRUITING

St Elisabeth Hospital Meerbusch Lank

Meerbusch, 40668, Germany

RECRUITING

Klinikum der Universitaet Muenchen

München, 80336, Germany

RECRUITING

Medicover Muenchen Ost MVZ

München, 81667, Germany

RECRUITING

Laiko General Hospital of Athens

Athens, 115 27, Greece

RECRUITING

University General Hospital Attikon General Hospital Of West Attica H Agia Varvara

Athens, 12461, Greece

RECRUITING

University General Hospital of Heraklion

Heraklion, 715 00, Greece

RECRUITING

General University Hospital Of Larissa

Larissa, 41110, Greece

RECRUITING

Semmelweis Egyetem Reumatologiai es Immunologiai Klinika

Budapest, 1023, Hungary

RECRUITING

Betegapolo Irgalmas Rend Budai Irgalmasrendi Korhaz

Budapest, 1027, Hungary

RECRUITING

Debreceni Egyetem Klinikai Kozpont

Debrecen, 4032, Hungary

RECRUITING

Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz

Gyula, 5700, Hungary

RECRUITING

Pecsi Tudomanyegyetem Klinikai Kozpont

Pécs, 7632, Hungary

RECRUITING

Szegedi Tudomanyegyetem Aok Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, 6725, Hungary

RECRUITING

Vita Verum Medical Egeszsegugyi Szolgaltato Bt

Székesfehérvár, 8000, Hungary

COMPLETED

Vital Medical Center Orvosi es Fogaszati Kozpont

Veszprém, 8200, Hungary

RECRUITING

Obudai Egeszsegugyi Centrum Kft

Zalaegerszeg, 8900, Hungary

RECRUITING

Bnai Zion Medical Center

Haifa, 31048, Israel

RECRUITING

Rambam Health Care Campus

Haifa, 3109601, Israel

RECRUITING

Carmel Medical Center

Haifa, 3436212, Israel

RECRUITING

Hadassah Ein-Qarem Medical Center

Jerusalem, 9112001, Israel

RECRUITING

Meir Medical Center

Kfar Saba, 4428164, Israel

RECRUITING

Galilee Medical Center

Nahariya, 2210001, Israel

RECRUITING

Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel

RECRUITING

Azienda Ospedaliero Universitaria Delle Marche

Ancona, 60126, Italy

RECRUITING

Ospedale San Raffaele di Milano

Milan, 20132, Italy

RECRUITING

Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia

Perugia, 06129, Italy

RECRUITING

Bio-Medico Campus University Hospital

Roma, 00128, Italy

RECRUITING

Azienda Ospedaliera San Camillo-Forlanini

Roma, 00152, Italy

RECRUITING

Fondazione Policlinico Universitario A Gemelli IRCCS

Roma, 00168, Italy

RECRUITING

Istituto Clinico Humanitas

Rozzano, 20089, Italy

RECRUITING

A.O. Ordine Mauriziano Di Torino - Ospedale Mauriziano Umberto

Torino, 10137, Italy

RECRUITING

Ospedale S. Maria Della Misericordia

Udine, 33100, Italy

RECRUITING

Azienda Ospedaliera Universitaria Integrata Verona

Verona, 37126, Italy

RECRUITING

Chukyo Hospital

Aichi, 457 8510, Japan

RECRUITING

Institute of Science Tokyo Hospital

Bunkyō City, 113 8519, Japan

RECRUITING

Juntendo University Hospital Urayasu

Chiba, 279 0021, Japan

RECRUITING

University of Yamanashi Hospital

Chūō, 409-3898, Japan

RECRUITING

Tokyo Metropolitan Tama Medical Center

Fuchū, 183 8524, Japan

RECRUITING

National Hospital Organization Kyushu Medical Center

Fukuoka, 810 8563, Japan

RECRUITING

Fukushima Medical University Hospital

Fukushima, 960 1295, Japan

RECRUITING

Tokai University Hospital

Isehara, 259-1193, Japan

RECRUITING

Shinkenko Clinic

Naha, 900 0015, Japan

RECRUITING

Kitano Hospital

Osaka, 530-8480, Japan

RECRUITING

Hokkaido University Hospital

Sapporo, 060-8648, Japan

RECRUITING

Tohoku Medical And Pharmaceutical University Hospital

Sendai, 983 0005, Japan

RECRUITING

Shimane University Hospital

Shimane, 693-8501, Japan

RECRUITING

National Center for Global Health and Medicine

Shinjuku- Ku, 162-8655, Japan

RECRUITING

St. Luke's International Hospital

Tokyo, 104 8560, Japan

RECRUITING

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

Tokyo, 113 8677, Japan

RECRUITING

Ome Medical Center

Tokyo, 198-0042, Japan

RECRUITING

Toyama University Hospital

Toyama, 930 0194, Japan

RECRUITING

Hospital Sultan Ismail

Johor Bahru, 81100, Malaysia

RECRUITING

Hospital Sultanah Nur Zahirah

Kuala, 20400, Malaysia

RECRUITING

University Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia

RECRUITING

Hospital Umum Sarawak

Kuching, 93586, Malaysia

RECRUITING

Sunway Medical Centre

Petaling Jaya, 47500, Malaysia

RECRUITING

Hospital Taiping

Taiping, 34000, Malaysia

RECRUITING

Haukeland University Hospital

Bergen, 5009, Norway

RECRUITING

Oslo universitetssykehus HF, Rikshospitalet

Oslo, 0372, Norway

RECRUITING

Stavanger University Hospital

Stavanger, 4011, Norway

RECRUITING

MICS Centrum Medyczne Bydgoszcz

Bydgoszcz, 85 065, Poland

RECRUITING

Jan Biziel's University Hospital

Bydgoszcz, 85 168, Poland

RECRUITING

Nzoz Bif Med

Bytom, 41 902, Poland

RECRUITING

Provita Sp z o o

Katowice, 40 611, Poland

RECRUITING

Malopolskie Badania Kliniczne Sp z o o

Krakow, 30-002, Poland

RECRUITING

NZOZ Lecznica MAK MED S C

Nadarzyn, 05 830, Poland

RECRUITING

Twoja Przychodnia - Centrum Medyczne Nowa Sol

Nowa Sól, 67 100, Poland

RECRUITING

Twoja Przychodnia Poznanskie Centrum Medyczne

Poznan, 60-324, Poland

RECRUITING

Innova Clinic sp z o o

Płońsk, 09 100, Poland

RECRUITING

MICS Centrum Medyczne Warszawa

Warsaw, 00-874, Poland

RECRUITING

Rheuma Medicus Sp z o o

Warsaw, 02 118, Poland

RECRUITING

Uls Almada Seixal - Hosp. Garcia de Orta

Almada, 2805 267, Portugal

RECRUITING

Uls Sao Jose - Hosp. Curry Cabral

Lisbon, 1069 166, Portugal

RECRUITING

Uls Santa Maria - Hosp. Santa Maria

Lisbon, 1649 028, Portugal

RECRUITING

Ulsam - Hosp. Conde de Bertiandos

Ponte de Lima, 4990-041, Portugal

RECRUITING

Uls Santo Antonio - Hosp. Santo Antonio

Porto, 4050 342, Portugal

RECRUITING

Centrul Medical de Diagnostic si Tratament Ambulator NEOMED

Brasov, 500283, Romania

RECRUITING

Spitalul Clinic Sfanta Maria

Bucharest, 011172, Romania

RECRUITING

CCBR Clinical Research

Bucharest, 030463, Romania

RECRUITING

Hiperdia Piata Sudului

Bucharest, 041303, Romania

RECRUITING

Spitalul Clinic Judetean de Urgenta Cluj

Cluj-Napoca, 400006, Romania

RECRUITING

Medisof Diagnostic S R L

Craiova, 200347, Romania

RECRUITING

Spitalul Clinic Judetean de Urgenta Bihor

Oradea, 410469, Romania

RECRUITING

Medbanat s r l

Timișoara, 300766, Romania

RECRUITING

Reumatologicka ambulancia MUDr Michaele Zarikova

Košice, 04011, Slovakia

RECRUITING

MEDMAN s.r.o.

Martin, 036 01, Slovakia

RECRUITING

Narodny Ustav Reumatickych Chorob

Piešťany, 921 12, Slovakia

RECRUITING

Dong-A University Hospital

Busan, 49201, South Korea

RECRUITING

Chonnam National University Hospital

Gwangju, 61469, South Korea

RECRUITING

Seoul National University Bundang Hospital

Gyeonggi-do, 13620, South Korea

RECRUITING

Seoul National University Hospital

Seoul, 03080, South Korea

RECRUITING

Hanyang University Medical Center

Seoul, 04763, South Korea

RECRUITING

Ajou University Hospital

Suwon, 16499, South Korea

RECRUITING

Hospital Vall d'Hebron

Barcelona, 08035, Spain

RECRUITING

Hosp. de La Santa Creu I Sant Pau

Barcelona, 8026, Spain

RECRUITING

Hosp. Gral. Juan Ramon Jimenez

Huelva, 21005, Spain

RECRUITING

Hosp. Univ. Infanta Leonor

Madrid, 28031, Spain

RECRUITING

Complejo Hosp de Navarra - Hosp de Navarra

Pamplona, 31008, Spain

RECRUITING

Hosp. Univ. Marques de Valdecilla

Santander, 39008, Spain

RECRUITING

Hosp. Clinico Univ. de Santiago

Santiago de Compostela, 15706, Spain

RECRUITING

Hosp. Infanta Luisa

Seville, 41010, Spain

RECRUITING

Hosp. Univ. Rio Hortega

Valladolid, 47012, Spain

RECRUITING

Hosp. Clinico Univ. Lozano Blesa

Zaragoza, 50009, Spain

RECRUITING

Universitatsspital Basel

Basel, 4031, Switzerland

RECRUITING

NTU Biomedical Park Hospital

Hsinchu, 302058, Taiwan

RECRUITING

Kaohsiung Veterans General Hospital

Kaohsiung City, 813414, Taiwan

RECRUITING

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 83301, Taiwan

RECRUITING

National Taiwan University Hospital

Taipei, 10043, Taiwan

RECRUITING

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

RECRUITING

Linkou Chang Gung Memorial Hospital

Taoyuan, 333, Taiwan

RECRUITING

Phramongkutklao Hospital

Bangkok, 10400, Thailand

RECRUITING

Ramathibodi Hospital Mahidol University

Bangkok, 10400, Thailand

RECRUITING

Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, 50200, Thailand

RECRUITING

Ankara University Medical Faculty

Ankara, 06050, Turkey (Türkiye)

RECRUITING

Ankara Bilkent Sehir Hastanesi

Ankara, 06800, Turkey (Türkiye)

RECRUITING

Firat University Hospital

Elâzığ, 23200, Turkey (Türkiye)

RECRUITING

Sanko Universitesi Hastanesi

Gaziantep, 27090, Turkey (Türkiye)

RECRUITING

Marmara University Istanbul Pendik Education and Research Hospital

Istanbul, 34899, Turkey (Türkiye)

RECRUITING

Necmettin Erbakan University Meram Medical Faculty

Konya, 42080, Turkey (Türkiye)

RECRUITING

Addenbrookes Hospital

Cambridge, CB2 0QQ, United Kingdom

RECRUITING

Guy's and St Thomas' NHS Foundation Trust

Greater London, SE1 9RT, United Kingdom

RECRUITING

Newcastle Freeman Hospital

Newcastle upon Tyne, NE7 7DN, United Kingdom

RECRUITING

Peterborough City Hospital

Peterborough, PE3 9GZ, United Kingdom

RECRUITING

Royal Berkshire Hospital

Reading, RG1 5LE, United Kingdom

RECRUITING

Southampton University Hospital

Southampton, SO16 6HU, United Kingdom

RECRUITING

Haywood Hospital

Stoke-on-Trent, ST6 7AG, United Kingdom

RECRUITING

Great Western Hospital

Swindon, SN3 6BB, United Kingdom

RECRUITING

MeSH Terms

Conditions

Lupus Erythematosus, Systemic

Condition Hierarchy (Ancestors)

Connective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • Janssen Research & Development, LLC Clinical Trial

    Janssen Research & Development, LLC

    STUDY DIRECTOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Participants will be randomly assigned to one of the 2 identical studies (conducted under this single protocol) to make a total of 300 participants in each study. Participants in each study will be randomly assigned to one of the arms nipocalimab or placebo respectively.
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 23, 2026

First Posted

February 27, 2026

Study Start

March 5, 2026

Primary Completion (Estimated)

December 6, 2028

Study Completion (Estimated)

November 7, 2031

Last Updated

July 31, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will share

The data sharing policy of Johnson \& Johnson Innovative Medicine is available at www.innovativemedicine.jnj.com/our-innovation/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu

More information

Locations