A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
ENLIGHTEN-6
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Persistent Obesity or Overweight Treated With a Weekly Incretin, With and Without Type 2 Diabetes
3 other identifiers
interventional
900
14 countries
178
Brief Summary
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Feb 2026
178 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 30, 2026
CompletedFirst Posted
Study publicly available on registry
February 6, 2026
CompletedStudy Start
First participant enrolled
February 10, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 1, 2028
March 20, 2026
March 1, 2026
2.3 years
January 30, 2026
March 19, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Percent Change from Baseline in Body Weight
Baseline, Week 64
Secondary Outcomes (15)
Change from Baseline in Waist Circumference
Baseline, Week 64
Percent Change in Baseline in Triglycerides
Baseline, Week 64
Change from Baseline in Systolic Blood Pressure
Baseline, Week 64
Change from Baseline in Body Mass Index (BMI)
Baseline, Week 64
Change from Baseline in Fasting Glucose in Participants with Type 2 Diabetes at Baseline
Baseline, Week 64
- +10 more secondary outcomes
Study Arms (5)
Eloralintide Dose 1
EXPERIMENTALParticipants will receive eloralintide subcutaneously (SC)
Eloralintide Dose 2
EXPERIMENTALParticipants will receive eloralintide SC
Eloralintide Dose 3
EXPERIMENTALParticipants will receive eloralintide SC
Eloralintide Dose 4
EXPERIMENTALParticipants will receive eloralintide SC
Placebo
PLACEBO COMPARATORParticipants will receive placebo SC
Interventions
Administered SC
Eligibility Criteria
You may qualify if:
- Are on stable incretin therapy at screening
- With persistent obesity or overweight defined as:
- ≥30 kg/m2 OR
- ≥27 kg/m2 with at least one existing obesity related complication at screening:
- hypertension
- dyslipidemia
- obstructive sleep apnea
- cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or
- type 2 diabetes
- Have a stable body weight (\<5% body weight change) at screening
You may not qualify if:
- Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
- Have type 1 diabetes
- Have taken any of the following antihyperglycemic medications within 90 days before screening:
- dipeptidyl peptidase-4 (DPP-4) inhibitors
- amylin analogs
- insulin
- Have had within 90 days prior to screening:
- heart attack
- stroke
- coronary artery revascularization
- unstable angina, or
- hospitalization due to congestive heart failure
- Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (178)
Birmingham Clinical Research
Birmingham, Alabama, 35209, United States
RIO Clinical Trials - Phoenix
Phoenix, Arizona, 85016, United States
Headlands Research - Scottsdale
Scottsdale, Arizona, 85260, United States
Novak Clinical Research - Tucson - North La Cholla Boulevard
Tucson, Arizona, 85741, United States
Irvine Clinical Research
Irvine, California, 92614, United States
Scripps Whittier Diabetes Institute
La Jolla, California, 92037, United States
Peninsula Research Associates
Rolling Hills Estates, California, 90274, United States
Care Access - Sacramento
Sacramento, California, 95831, United States
Artemis Institute for Clinical Research
San Diego, California, 92123, United States
Southern California Clinical Research
Santa Ana, California, 92701, United States
University Clinical Investigators, Inc.
Tustin, California, 92780, United States
New England Research Associates, LLC
Bridgeport, Connecticut, 06606, United States
Yale University School of Medicine
New Haven, Connecticut, 06519, United States
Chase Medical Research, LLC
Waterbury, Connecticut, 06708, United States
JEM Research Institute
Atlantis, Florida, 33462, United States
AMR Clinical
Doral, Florida, 33172, United States
Northeast Research Institute (NERI)
Fleming Island, Florida, 32003, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
New Horizon Research Center
Miami, Florida, 33165, United States
St Johns Center for Clinical Research
Saint Augustine, Florida, 32086, United States
Metabolic Research Institute, Inc.
West Palm Beach, Florida, 33401, United States
Teak Research Consults - Dunwoody
Dunwoody, Georgia, 30338, United States
Center for Advanced Research & Education
Gainesville, Georgia, 30501, United States
Family First Medical Center
Idaho Falls, Idaho, 83404, United States
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, 60640, United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, 50266, United States
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, 66606, United States
AMR Clinical
Lexington, Kentucky, 40509, United States
IMA Clinical Research Monroe - Armand
Monroe, Louisiana, 71201, United States
Centennial Medical Group
Columbia, Maryland, 21045, United States
Brigham and Women's Hospital Diabetes Program
Boston, Massachusetts, 02115, United States
Great Lakes Research Institute
Southfield, Michigan, 48075, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, 48098, United States
Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
NYU Langone Health
New York, New York, 10016, United States
Weill Cornell Medical College
New York, New York, 10021, United States
IMA Clinical Research Manhattan
New York, New York, 10036, United States
University of North Carolina Medical Center
Chapel Hill, North Carolina, 27514, United States
Medication Management
Greensboro, North Carolina, 27405, United States
Carteret Medical Group
Morehead City, North Carolina, 28557, United States
Accellacare - Wilmington - 1917 Tradd Court
Wilmington, North Carolina, 28401, United States
Care Access - Lima
Lima, Ohio, 45805, United States
Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)
Pittsburgh, Pennsylvania, 15236, United States
UT Southwestern Medical Center
Dallas, Texas, 75390, United States
Juno Research
Houston, Texas, 77040, United States
Synergy Groups Medical LLC - Missouri City
Missouri City, Texas, 77459, United States
IMA Clinical Research San Antonio
San Antonio, Texas, 78229, United States
Endeavor Clinical Trials
San Antonio, Texas, 78240, United States
Consano Clinical Research, LLC
Shavano Park, Texas, 78231, United States
Texas Valley Clinical Research
Weslaco, Texas, 78596, United States
Medrasa Clinical Research
Wylie, Texas, 75098, United States
Emeritus Research
Botany, 2019, Australia
Box Hill Hospital
Box Hill, 3128, Australia
Royal Brisbane and Women's Hospital
Brisbane, 4029, Australia
Emeritus Research
Camberwell, 3124, Australia
Barwon Health
Geelong, 3220, Australia
Austin Health - Repatriation Hospital
Heidelberg West, 3081, Australia
AIM Research
Merewether, 2291, Australia
Southern Adelaide Diabetes & Endocrine Services
Oaklands Park, 5046, Australia
Royal North Shore Hospital
St Leonards, 2065, Australia
Innovate Clinical Research
Waitara, 2077, Australia
Imelda General Hospital
Bonheiden, 2820, Belgium
Université Libre de Bruxelles - Hôpital Erasme
Brussels, 1070, Belgium
Ziekenhuis Oost-Limburg, Campus St.-Jan
Genk, 3600, Belgium
Jan Yperman Ziekenhuis
Ieper, 8900, Belgium
AZ Groeninge Campus Kennedylaan
Kortrijk, 8500, Belgium
UZ Leuven
Leuven, 3000, Belgium
AZ Sint-Maarten
Mechelen, 2800, Belgium
Meclinas
Mechelen, 2800, Belgium
Az Damiaan vzw
Ostend, 8400, Belgium
Quanta Diagnóstico e Terapia
Curitiba, 80045170, Brazil
Centro de Diabetes Curitiba
Curitiba, 80810-040, Brazil
Private Practice - Dr.Miguel N. Hissa
Fortaleza, 60430-350, Brazil
CPCLIN
São Paulo, 01228-200, Brazil
Hospital 9 De Julho
São Paulo, 01409-901, Brazil
CEDOES
Vitória, 29055450, Brazil
Integral Pesquisa e Ensino
Votuporanga, 15500-269, Brazil
Luhe Hospital
Beijing, 100000, China
The First Hospital of Jilin University
Changchun, 130021, China
The Second Hospital of Jilin University
Changchun, 130041, China
The Second Xiangya Hospital of Central South University
Changsha, 410011, China
Sichuan Provincial People's Hospital
Chengdu, 610072, China
West China Hospital Sichuan University
Chengdu, 610041, China
2nd Affiliated Hospital Chongqing Medical Universi
Chongqing, 400000, China
Zhujiang Hospital
Guangzhou, 510280, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, 550004, China
The Second People's Hospital of Hefei
Hefei, 230011, China
Huzhou Central Hospital
Huzhou, 313000, China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, 471023, China
Affiliated Hospital of Luzhou Medical College
Luzhou, 646000, China
Jiangxi Provincial People's Hospital
Nanchang, 330006, China
Nanjing First Hospital
Nanjing, 210006, China
Zhongda Hospital Southeast University
Nanjing, 210009, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, 210011, China
Ningbo First Hospital
Ningbo, 315010, China
Zhongshan Hospital,Fudan University
Shanghai, 200032, China
The Central Hospital of Wuhan
Wuhan, 430014, China
Diahaza s.r.o.
Holešov, 769 01, Czechia
MUDr. Michala Pelikanova s.r.o.
Prague, 140 00, Czechia
Milan Kvapil s.r.o., Diabetologicka ambulance
Prague, 14900, Czechia
ResTrial s.r.o.
Prague, 18100, Czechia
Motilal Nehru Medical College Hospital
Allahabād, 211002, India
Life Care Hospital and Research Centre
Bangalore, 560092, India
Madras Diabetes Research Foundation
Chennai, 600086, India
Nizam's Institute of Medical Sciences
Hyderabad, 500082, India
Eternal Heart Care Center and Research Institute
Jaipur, 302020, India
Atmaram Child Care
Kanpur, 208011, India
Shree Mahalaxmi DIATONE Institute
Kolhāpur, 416001, India
BSES MG Hospital
Mumbai, 400058, India
Mysore Medical College
Mysore, 570001, India
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, 441108, India
Supe Heart & Diabetes Hospital and Research Centre
Nashik, 422002, India
Nirmal Hospital Pvt Ltd.
Surat, 395002, India
Emek Medical Center
Afula, 1834111, Israel
Clalit Health Services - Atlit
Atlit, 3032301, Israel
Soroka Medical Center
Beersheba, 8410101, Israel
Hillel Yaffe Medical Center
Hadera, 3810101, Israel
Rambam Health Care Campus
Haifa, 3109601, Israel
Edith Wolfson Medical Center
Holon, 5810001, Israel
Hadassah Medical Center
Jerusalem, 9112001, Israel
Meir Medical Center
Kfar Saba, 4428164, Israel
Maccabi health care services - Qiryat Motzkin
Kiryat Motzkin, 2642435, Israel
Laniado Hospital
Netanya, 4244914, Israel
Rabin Medical Center - Hasharon Campus
Petah Tikva, 4937211, Israel
Rabin Medical Center
Petah Tikva, 4941492, Israel
Sheba Medical Center
Ramat Gan, 5262100, Israel
Kaplan Medical Center
Rehovot, 7610001, Israel
Clalit Health Services - Sakhnin Community Clinic
Sakhnin, 3081000, Israel
Diabetes Medical Center
Tel Aviv, 51549, Israel
Sourasky Medical Center
Tel Aviv, 6423906, Israel
The Institute of Medical Science, Asahi Life Foundation
Chūōku, 103-0002, Japan
Rinku General Medical Center
Izumisano, 598-8577, Japan
Kanto Rosai Hospital
Kawasaki, 211-8510, Japan
Kimitsu Chuo Hospital
Kisarazu, 292-8535, Japan
Kure Medical Center
Kure, 737-0023, Japan
Takeda General Hospital - Kyoto
Kyoto, 601-1495, Japan
Mikannohana Clinic, Diabetes, Endocrinology and Metabolism
Matsuyama, 7900034, Japan
Kansai Electric Power Hospital
Osaka, 553-0003, Japan
Manda Memorial Hospital
Sapporo, 060-0062, Japan
Shimonoseki Medical Center
Shimonoseki, 750-0061, Japan
Japanese Red Cross Society - Wakayama Medical Center
Wakayama, 640-8558, Japan
Medical Center Metas
Chihuahua City, 31110, Mexico
Private Practice - Dr. Arechavaleta Granell Maria del Rosario
Guadalajara, 44670, Mexico
Invecordis S.C.
Huixquilucan, 52763, Mexico
Centro de Investigacion en Artritis y Osteoporosis SC
Mexicali, 21200, Mexico
CEINV Salud
Monterrey, 64020, Mexico
Clínica García Flores SC
Monterrey, 64610, Mexico
Advanced Clinical Research, LLC
Bayamón, 00959, Puerto Rico
Isis Clinical Research Center
Guaynabo, 00968, Puerto Rico
Mariodiab Clinic
Brasov, 500097, Romania
C.M.D.T.A. Neomed
Brasov, 500283, Romania
Geea Medical Easy Diet
Bucharest, 010627, Romania
Centrul Medical NutriLife
Bucharest, 013764, Romania
Gama Diamed
Mangalia, 905500, Romania
Diabdana
Oradea, 410147, Romania
Clinica Korall
Satu Mare, 440055, Romania
Rinart Diab SRL
Târgovişte, 130168, Romania
SC Dentosim Queen SRL - Centrul Medical Diamed
Târgu Mureş, 540098, Romania
Cabinet Medical Dr.Geru
Timișoara, 300288, Romania
Hospital San Rafael - La Coruña
A Coruña, 15006, Spain
Centro Periférico de Especialidades Bola Azul
Almería, 04009, Spain
Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
Instituto Gallego de Cirugía Ocular
Ferrol, 15402, Spain
Clínica Juaneda
Palma de Mallorca, 07014, Spain
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, 28223, Spain
Hospital Universitario Marqués de Valdecilla
Santander, 39008, Spain
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
Seville, 41003, Spain
Hospital Quiron Infanta Luisa
Seville, 41010, Spain
Vithas Hospital Sevilla
Seville, 41950, Spain
Chiayi Christian Hospital
Chiayi City, 600, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, 83301, Taiwan
China Medical University Hospital
Taichung, 404332, Taiwan
National Cheng Kung University Hospital
Tainan, 704, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
Taipei Medical University Hospital
Taipei, 110, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Chang Gung Medical Foundation-Linkou Branch
Taoyuan District, 333, Taiwan
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Central Study Contacts
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
CONTACT
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 30, 2026
First Posted
February 6, 2026
Study Start
February 10, 2026
Primary Completion (Estimated)
June 1, 2028
Study Completion (Estimated)
July 1, 2028
Last Updated
March 20, 2026
Record last verified: 2026-03
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.
- Access Criteria
- A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.
Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.