A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
ENLIGHTEN-2
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, and Type 2 Diabetes
3 other identifiers
interventional
1,035
14 countries
159
Brief Summary
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Dec 2025
159 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 5, 2025
CompletedFirst Posted
Study publicly available on registry
December 15, 2025
CompletedStudy Start
First participant enrolled
December 15, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
February 1, 2028
April 17, 2026
April 1, 2026
2 years
December 5, 2025
April 16, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Percent Change from Baseline in Body Weight
Baseline, Week 64
Secondary Outcomes (16)
Percent Change from Baseline in Total Body Fat Mass
Baseline, Week 64
Change from Baseline in Waist Circumference
Baseline, Week 64
Change from Baseline in Hemoglobin A1c (HbA1c)
Baseline, Week 64
Percent Change in Baseline in Triglycerides
Baseline, Week 64
Change from Baseline in Systolic Blood Pressure
Baseline, Week 64
- +11 more secondary outcomes
Study Arms (5)
Eloralintide Dose 1
EXPERIMENTALParticipants will receive eloralintide subcutaneously (SC)
Eloralintide Dose 2
EXPERIMENTALParticipants will receive eloralintide SC
Eloralintide Dose 3
EXPERIMENTALParticipants will receive eloralintide SC
Eloralintide Dose 4
EXPERIMENTALParticipants will receive eloralintide SC
Placebo
PLACEBO COMPARATORParticipants will receive placebo SC
Interventions
Administered SC
Eligibility Criteria
You may qualify if:
- Have type 2 diabetes
- Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
- Have a BMI ≥ 27 kg/m2
- Have a stable body weight (\<5% body weight change) for 90 days prior to screening
You may not qualify if:
- Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
- Have type 1 diabetes
- Have taken any of the following antihyperglycemic medications within 90 days before screening:
- amylin analogs
- glucagon-like peptide-1 (GLP-1) receptor agonists
- glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or
- insulin
- Have had within 90 days prior to screening:
- heart attack
- stroke
- coronary artery revascularization
- unstable angina, or
- hospitalization due to congestive heart failure
- Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
- +1 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (159)
Birmingham Clinical Research
Birmingham, Alabama, 35209, United States
Cullman Clinical Trials
Cullman, Alabama, 35055, United States
Tucson Clinical Research Institute
Tucson, Arizona, 85712, United States
San Fernando Valley Health Institute
Canoga Park, California, 91304, United States
AMCR Institute
Escondido, California, 92025, United States
NorCal Medical Research, Inc
Greenbrae, California, 94904, United States
Inglewood Clinical
Inglewood, California, 90301, United States
Ark Clinical Research
Long Beach, California, 90815, United States
Pacific Clinical Studies
Los Alamitos, California, 90720, United States
Care Access - Santa Clarita
Santa Clarita, California, 91321, United States
Encompass Clinical Research
Spring Valley, California, 91978, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, 94598, United States
Care Access - Aurora
Aurora, Colorado, 80012, United States
New England Research Associates, LLC
Bridgeport, Connecticut, 06606, United States
CMR of Greater New Haven, LLC
Hamden, Connecticut, 06517, United States
Arrow Clinical Trials
Daytona Beach, Florida, 32117, United States
Care Access - Delray Beach
Delray Beach, Florida, 33484, United States
Fleming Island Center for Clinical Research
Fleming Island, Florida, 32003, United States
Nature Coast Clinical Research - Inverness
Inverness, Florida, 34452, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
Flourish Research Acquisition, LLC dba Flourish Research - North Miami
Miami, Florida, 33138, United States
New Horizon Research Center
Miami, Florida, 33165, United States
Adult Medicine of Lake County, Inc.
Mt. Dora, Florida, 32757, United States
American Research Centers of Florida
Pembroke Pines, Florida, 33027, United States
Clinical Site Partners, LLC dba Flourish Research
Winter Park, Florida, 32789, United States
Teak Research Consults - Dunwoody
Dunwoody, Georgia, 30338, United States
Teak Research Consults
Lawrenceville, Georgia, 30043, United States
The Jones Center Clinical Research
Macon, Georgia, 31210, United States
Pacific Diabetes & Endocrine Center
Honolulu, Hawaii, 96817, United States
NorthShore University Health System
Skokie, Illinois, 60077, United States
DM Clinical Research - Indianapolis
Indianapolis, Indiana, 46254, United States
Clinical Trials Management, LLC d/b/a Flourish Research
Metairie, Louisiana, 70006, United States
IMA Clinical Research Monroe - Armand
Monroe, Louisiana, 71201, United States
Centennial Medical Group
Columbia, Maryland, 21045, United States
Lucida Clinical Trials
New Bedford, Massachusetts, 02740, United States
Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
Clinvest Headlands Llc
Springfield, Missouri, 65807, United States
Hypertension & Nephrology Association
Eatontown, New Jersey, 07724, United States
IMA Clinical Research Warren
Warren Township, New Jersey, 07059, United States
Albuquerque Clinical Trials, Inc.
Albuquerque, New Mexico, 87102, United States
NYC Research INC
Long Island City, New York, 11106, United States
PharmQuest Life Sciences, LLC
Greensboro, North Carolina, 27408, United States
West Clinical Research
Morehead City, North Carolina, 28557, United States
Trial Management Associates - Wilmington - Floral Parkway
Wilmington, North Carolina, 28403, United States
Lillestol Research
Fargo, North Dakota, 58104, United States
Care Access - Lima
Lima, Ohio, 45805, United States
Summit Headlands
Portland, Oregon, 97210, United States
Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
Pittsburgh, Pennsylvania, 15243, United States
Preferred Primary Care Physicians
Uniontown, Pennsylvania, 15401, United States
Accellacare - Mt Pleasant
Mt. Pleasant, South Carolina, 29464, United States
IMA Clinical Research Austin
Austin, Texas, 78745, United States
Private Practice - Dr. Osvaldo A. Brusco
Corpus Christi, Texas, 78414, United States
Velocity Clinical Research, Dallas
Dallas, Texas, 75230, United States
Diabetes and Thyroid Center of Ft. Worth
Fort Worth, Texas, 76132, United States
Juno Research
Houston, Texas, 77040, United States
Southern Endocrinology Associates
Mesquite, Texas, 75149, United States
Research Your Health
Plano, Texas, 75093, United States
IMA Clinical Research San Antonio
San Antonio, Texas, 78229, United States
Ogden Clinic - Canyon View
Ogden, Utah, 84404, United States
Diabetes & Endocrine Treatment Specialists
Sandy City, Utah, 84093, United States
Stat Research S.A.
Buenos Aires, C1023AAB, Argentina
Investigaciones Medicas Imoba Srl
Buenos Aires, C1056ABH, Argentina
Centro de Investigaciones Metabólicas (CINME)
Buenos Aires, C1056ABI, Argentina
Mautalen Salud e Investigación
Buenos Aires, C1128AAF, Argentina
Asociación de Beneficencia Hospital Sirio Libanés
Buenos Aires, C1419AHN, Argentina
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Buenos Aires, C1425AGC, Argentina
Instituto Centenario
CABA, 1204, Argentina
Centro Diabetológico Dr. Waitman
Córdoba, 5000, Argentina
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, 2152, Argentina
Fundacion Estudios Clinicos
Rosario, 2000, Argentina
Instituto Médico Catamarca IMEC
Rosario, 2000, Argentina
Luhe Hospital
Beijing, 100000, China
Peking University People's Hospital
Beijing, 100034, China
Beijing Pinggu District Hospital
Beijing, 101200, China
Sichuan Provincial People's Hospital
Chengdu, 610072, China
The Second Affiliated Hospital Chongqing Medical University
Chongqing, 400010, China
Zhujiang Hospital
Guangzhou, 510280, China
The Second People's Hospital of Hefei
Hefei, 230011, China
Jinan Central Hospital
Jinan, 250013, China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, 471003, China
Jiangxi Provincial People's Hospital
Nanchang, 330006, China
Nanjing First Hospital
Nanjing, 210006, China
Jiangsu Province Official Hospital
Nanjing, 210008, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, 210011, China
Jiading District Central Hospital
Shanghai, 201800, China
The Second Hospital of Tianjin Medical University
Tianjin, 300211, China
Zigong First People's Hospital
Zigong, 643000, China
MUDr. Tomas Edelsberger
Krnov, 79401, Czechia
MUDr. Miroslav Koliba s.r.o.
Ostrava, 702 00, Czechia
MUDr. Jana Parkanyiova
Prague, 110 00, Czechia
Diabet2 s.r.o., diabetologicka a interni ambulance
Prague, 11000, Czechia
Diabetespraxis Dr. Braun
Berlin, 13187, Germany
Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann
Bünde, 32257, Germany
InnoDiab Forschung Gmbh
Essen, 45136, Germany
Diabetes Zentrum Wilhelmsburg
Hamburg, 21109, Germany
Institut für Diabetesforschung GmbH Münster
Münster, 48145, Germany
Schwerpunktpraxis für Diabetes und Ernährungsmedizin Dr. med. Winfried Keuthage
Münster, 48153, Germany
RED-Institut GmbH
Oldenburg, 23758, Germany
Life Care Hospital and Research Centre
Bangalore, 560092, India
Belagavi Institute of Medical Sciences - Belagavi
Belgavi, 590019, India
Dr. Ram Manohar Lohia Institute of Medical Sciences
Lucknow, 226010, India
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, 441108, India
Lifepoint Multispeciality Hospital
Pune, 411057, India
Ashirwad Hospital and Research Centre
Ulhasnagar, 421004, India
Hayashi Diabetes Internal Medicine Clinic
Chigasaki, 253-0044, Japan
Tokyo-Eki Center-building Clinic
Chūōku, 103-0027, Japan
Shonan Takai Clinic
Kamakura, 247-0055, Japan
Oishi Clinic
Kasuya-gun, 811-2310, Japan
OHAMA Diabetes Clinic
Kawaguchi, 332-0015, Japan
Higashijujo Sakai Diabetes Internal Medicine Clinic
Kita-ku, 114-0001, Japan
Tokuyama Clinic
Mihama-ku,Chiba City, 261-0004, Japan
Shinkenko clinic
Naha, 900-0015, Japan
Oyama East Clinic
Oyama, 323-0022, Japan
Shimokitazawa Tomo Clinic
Setagaya-ku, 155-0031, Japan
Soka Sugiura Internal Medicine Clinic
Sōka, 340-0015, Japan
Tsuchiura Medical & Health Care Center
Tsuchiura, 300-0012, Japan
Tsuchiura Beryl Clinic
Tsuchiura, 300-0062, Japan
Noritake Clinic
Ushiku, 300-1207, Japan
Yokohama Minoru Clinic
Yokohama, 232-0064, Japan
Centro de Investigacion Medica de Occidente, S.C.
Guadalajara, 44260, Mexico
Instituto Jalisciense de Investigacion en Diabetes y Obesidad
Guadalajara, 44600, Mexico
Unidad de Investigación Clínica y Atención Médica HEPA S.C.
Guadalajara, 44670, Mexico
Medical Care and Research SA de CV
Mérida, 97070, Mexico
Cardiolink Clin Trials
Monterrey, 64060, Mexico
Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna
Bialystok, 15445, Poland
Centrum Medyczne NEUROMED
Bydgoszcz, 85-163, Poland
Ambulatorium Sp. z o.o.
Elblag, 82-300, Poland
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
Krakow, 31-261, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
Lodz, 90-338, Poland
Ekamed
Lublin, 20-718, Poland
NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki
Ruda Śląska, 41-709, Poland
Samodzielny Publiczny Szpital Kliniczny nr 1 SUM
Zabrze, 41-800, Poland
Centro de Endocrinologia y Nutricion
Caguas, 00725, Puerto Rico
Dorado Medical Complex
Dorado, 00646, Puerto Rico
Diacrin s.r.o.
Bratislava, 83101, Slovakia
MediVet s.r.o.
Malacky, 901 01, Slovakia
B-Medical, s.r.o.
Námestovo, 02901, Slovakia
FUNKYSTUFF s.r.o.
Nové Zámky, 940 02, Slovakia
DIA-MED CENTRUM s.r.o.
Púchov, 020 01, Slovakia
MEDI-DIA s.r.o.
Sabinov, 083 01, Slovakia
Korea University Ansan Hospital
Ansan-si, 15355, South Korea
Hanyang University Guri Hospital
Guri-si, 11923, South Korea
Chosun University Hospital
Gwangju, 61453, South Korea
Seoul National University Bundang Hospital
Seongnam, 13620, South Korea
Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
Hospital Universitario de La Ribera
Alzira, 46600, Spain
Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
Hospital Clínic de Barcelona
Barcelona, 08036, Spain
Complejo Hospitalario Ruber Juan Bravo
Madrid, 28006, Spain
H.R.U Málaga - Hospital Civil
Málaga, 29009, Spain
Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
Centro Médico Compostela
Santiago de Compostela, 15702, Spain
Hospital Universitario Virgen Del Rocio
Seville, 41013, Spain
Vithas Hospital Sevilla
Seville, 41950, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, 83301, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Chang Gung Medical Foundation-Linkou Branch
Taoyuan District, 333, Taiwan
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Central Study Contacts
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
CONTACT
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 5, 2025
First Posted
December 15, 2025
Study Start
December 15, 2025
Primary Completion (Estimated)
January 1, 2028
Study Completion (Estimated)
February 1, 2028
Last Updated
April 17, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.
- Access Criteria
- A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.
Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.