A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
ENLIGHTEN-1
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes
3 other identifiers
interventional
1,980
15 countries
173
Brief Summary
The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 obesity
Started Feb 2026
Longer than P75 for phase_3 obesity
173 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 5, 2026
CompletedFirst Posted
Study publicly available on registry
January 7, 2026
CompletedStudy Start
First participant enrolled
February 6, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 1, 2030
April 20, 2026
April 1, 2026
2.1 years
January 5, 2026
April 17, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Percent Change from Baseline in Body Weight
Baseline, Week 64
Secondary Outcomes (18)
Percent Change from Baseline in Total Body Fat Mass
Baseline, Week 64
Change from Baseline in Waist Circumference
Baseline, Week 64
Percent Change from Baseline in Triglycerides
Baseline, Week 64
Change from Baseline in Systolic Blood Pressure (SBP)
Baseline, Week 64
Time to Onset of Type 2 Diabetes (T2D)
Baseline to Week 168 and Week 191
- +13 more secondary outcomes
Study Arms (5)
Eloralintide Dose 1
EXPERIMENTALParticipants will receive eloralintide subcutaneously (SC)
Eloralintide Dose 2
EXPERIMENTALParticipants will receive eloralintide SC
Eloralintide Dose 3
EXPERIMENTALParticipants will receive eloralintide SC
Eloralintide Dose 4
EXPERIMENTALParticipants will receive eloralintide SC
Placebo
PLACEBO COMPARATORParticipants will receive placebo SC
Interventions
Administered SC
Eligibility Criteria
You may qualify if:
- Have Body Mass Index (BMI) at screening of the following:
- kilogram per square meter (kg/m2) OR
- kg/m2 with at least one of the following weight-related health conditions at screening:
- high blood pressure
- dyslipidemia
- obstructive sleep apnea, or
- heart disease
- Have a stable body weight (\<5% body weight change) for 90 days prior to screening.
- Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight
You may not qualify if:
- Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
- Have type 1 diabetes or type 2 diabetes
- Have had within 90 days prior to screening:
- heart attack
- stroke
- coronary artery revascularization
- unstable angina, or
- hospitalization due to congestive heart failure
- Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
- Have taken medications or alternative remedies intended for weight loss within 90 days of screening
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (173)
MFA Clinical Research
Tuscaloosa, Alabama, 35405, United States
Headlands Research - Scottsdale
Scottsdale, Arizona, 85260, United States
Neighborhood Healthcare Institute of Health
Escondido, California, 92025, United States
Ark Clinical Research - Fountain Valley
Fountain Valley, California, 92708, United States
Desert Oasis Healthcare Medical Group
Palm Springs, California, 92262, United States
Peninsula Research Associates
Rolling Hills Estates, California, 90274, United States
Care Access - Sacramento
Sacramento, California, 95831, United States
Southern California Clinical Research
Santa Ana, California, 92701, United States
University Clinical Investigators, Inc.
Tustin, California, 92780, United States
Chase Medical Research, LLC
Waterbury, Connecticut, 06708, United States
JEM Research Institute
Atlantis, Florida, 33462, United States
BioMed Research & Medical Center
Miami, Florida, 33156, United States
Adult Medicine of Lake County, Inc.
Mt. Dora, Florida, 32757, United States
American Research Centers of Florida
Pembroke Pines, Florida, 33027, United States
AHF Pensacola
Pensacola, Florida, 32503, United States
IMA Clinical Research St. Petersburg
St. Petersburg, Florida, 33704, United States
Teak Research Consults - Dunwoody
Dunwoody, Georgia, 30338, United States
Teak Research Consults
Lawrenceville, Georgia, 30043, United States
Clinical Research Atlanta
Stockbridge, Georgia, 30281, United States
East-West Medical Research Institute
Honolulu, Hawaii, 96814, United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, 50266, United States
Cotton O'Neil Clinical Research Center
Topeka, Kansas, 66606, United States
Care Access - Lake Charles (Bayou Pines)
Lake Charles, Louisiana, 70601, United States
MedStar Good Samaritan Hospital
Baltimore, Maryland, 21239, United States
MedStar Health Research Institute (MedStar Physician Based Research Network)
Hyattsville, Maryland, 20782, United States
Care Access - Quincy
Quincy, Massachusetts, 02169, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, 48098, United States
AMR Clinical
Las Vegas, Nevada, 89119, United States
IMA Clinical Research Warren
Warren Township, New Jersey, 07059, United States
Albuquerque Clinical Trials, Inc.
Albuquerque, New Mexico, 87102, United States
Rochester Clinical Research, LLC
Rochester, New York, 14609, United States
Monroe Biomedical Research
Monroe, North Carolina, 28112, United States
Preferred Primary Care Physicians
Uniontown, Pennsylvania, 15401, United States
Tribe Clinical Research, LLC
Greenville, South Carolina, 29607, United States
Accellacare - Mt Pleasant
Mt. Pleasant, South Carolina, 29464, United States
AMR Clinical
Nashville, Tennessee, 37203, United States
The University of Texas Health Science Center at Houston
Bellaire, Texas, 77401, United States
Velocity Clinical Research, Dallas
Dallas, Texas, 75230, United States
UT Southwestern Medical Center
Dallas, Texas, 75390-9302, United States
IMA Clinical Research San Antonio
San Antonio, Texas, 78229, United States
AMR Clinical
Norfolk, Virginia, 23502, United States
CONEXA Investigacion Clinica S.A.
Buenos Aires, 1012, Argentina
CIPREC
Buenos Aires, 1061, Argentina
Cicemo Srl
Buenos Aires, 1424, Argentina
Cardiología Palermo
Buenos Aires, 1425, Argentina
Glenny Corp. S.A.
Buenos Aires, 1430, Argentina
CARDIAMET Investigaciones Médicas
Buenos Aires, C1014ACP, Argentina
Centro Médico Viamonte
Buenos Aires, C1120AAC, Argentina
Fundación Respirar
Buenos Aires, C1426ABP, Argentina
CEDIC
CABA, C1060ABN, Argentina
Instituto de Investigaciones Clínicas Córdoba
Córdoba, 5000, Argentina
CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, M5501ARP, Argentina
INECO Neurociencias Oroño
Rosario, 2000, Argentina
Instituto Especialidades de la Salud Rosario
Rosario, 2000, Argentina
Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
Rosario, 2000, Argentina
Laboratorio de Hemostasia y Trombosis
Rosario, S2000DTB, Argentina
Centro de Investigaciones Médicas Tucuman
SAN M. de Tucuman, T4000AXL, Argentina
Centro Modelo de Cardiología
San Miguel de Tucumán, 4000, Argentina
Centro de Salud e Investigaciones Médicas
Santa Rosa, L6300, Argentina
Emeritus Research
Botany, 2019, Australia
Core Research Group
Brisbane, 4064, Australia
Paratus Clinical Research Canberra
Bruce, 2617, Australia
Emeritus Research
Camberwell, 3124, Australia
Life Clinical Research
Ipswich, 4305, Australia
Paratus Clinical Research Central Coast
Kanwal, 2259, Australia
University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook
Meadowbrook, 4131, Australia
Momentum Sunshine
Melbourne, 3021, Australia
Paratus Clinical Research - Melbourne
Melbourne, 3070, Australia
AIM Research
Merewether, 2291, Australia
Fusion Clinical Research
Norwood, 5067, Australia
USC Clinical Trials Sunshine Coast
Sippy Downs, 4556, Australia
ANIMA Research
Diepenbeek, 3590, Belgium
Jessa Ziekenhuis
Hasselt, 3500, Belgium
Kormont
Kluisbergen, 9690, Belgium
Gezondheidshuis De Gloed
Machelen, 9870, Belgium
Chronos Pesquisa Clínica
Brasília, 72145-450, Brazil
Instituto de Pesquisa clinica de Campinas
Campinas, 13060-080, Brazil
Centro de Pesquisa Sao Lucas
Campinas, 13060-803, Brazil
Private Practice - Dr.Miguel N. Hissa
Fortaleza, 60430-350, Brazil
Centro de Pesquisa Clínica de Marília - CPCLIM
Marília, 17504-072, Brazil
Núcleo de Pesquisa Clínica do Rio Grande do Sul
Porto Alegre, 90430-001, Brazil
IBPClin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, 20241-180, Brazil
Ruschel Medicina e Pesquisa Clínica
Rio de Janeiro, 22270-060, Brazil
CPHosp Medicina, Ensino e Pesquisa (CPQuali)
São Paulo, 01228-000, Brazil
CPCLIN
São Paulo, 01228-200, Brazil
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, 04266-010, Brazil
CEDOES
Vitória, 29055450, Brazil
Integral Pesquisa e Ensino
Votuporanga, 15500-269, Brazil
Aggarwal and Associates Limited
Brampton, L6T 0G1, Canada
Med Trust Research
Courtice, L1E 2J5, Canada
Dawson Clinical Research Inc.
Guelph, N1H 1B1, Canada
Winterberry Research Inc.
Hamilton, L8J 0B6, Canada
The Wharton Medical Clinic Clinical Trials Inc
Hamilton, L8L 5G8, Canada
Alpha Recherche Clinique
Québec, G2J 0C4, Canada
ALPHA Recherche Clinique
Québec, G3K 2P8, Canada
Bluewater Clinical Research Group Inc.
Sarnia, N7T 4X3, Canada
Diex Recherche Inc. Division Trois-Rivieres
Trois-Rivières, G9A 4P3, Canada
Luhe Hospital
Beijing, 1001199, China
Beijing Pinggu District Hospital
Beijing, 101200, China
Sichuan Provincial People's Hospital
Chengdu, 610072, China
West China Hospital Sichuan University
Chengdu, 610041, China
Zhujiang Hospital
Guangzhou, 510280, China
The Second People's Hospital of Hefei
Hefei, 230011, China
Jinan Central Hospital
Jinan, 250013, China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, 471003, China
Jiangxi Provincial People's Hospital
Nanchang, 330006, China
Nanjing First Hospital
Nanjing, 210006, China
Jiangsu Province Official Hospital
Nanjing, 210008, China
Zhongda Hospital Southeast University
Nanjing, 210009, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, 210011, China
Shanghai Sixth People's Hospital
Shanghai, China
Zentrum fur klinische Forschung - Köln
Cologne, 51069, Germany
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, 01307, Germany
StudyPoint Duisburg
Duisburg, 47269, Germany
InnoDiab Forschung Gmbh
Essen, 45136, Germany
Medizentrum Essen Borbeck
Essen, 45355, Germany
Diabetes Zentrum Wilhelmsburg
Hamburg, 21109, Germany
Diabeteszentrum Hamburg West
Hamburg, 22607, Germany
AmBeNet GmbH
Leipzig, 04107, Germany
Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz
Lingen, 49808, Germany
BAG Drs. Med. Quist PartG
Mainz, 55128, Germany
CRS Clinical Research Services Mannheim
Mannheim, 68167, Germany
RED-Institut GmbH
Oldenburg, 23758, Germany
Praxis Sauter & Sauter & Vorbach
Wangen, 88239, Germany
Endolife Speciality Hospitals
Guntur, 522001, India
Gauhati Medical College and Hospital
Guwahati, 781032, India
Care Hospitals Hyderabad- Banjara Hills
Hyderabad, 500034, India
Mandya Institute Of Medical Sciences
Mandya, 571401, India
Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
Mumbai, 400008, India
Mysore Medical College
Mysore, 570001, India
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, 441108, India
Supe Heart & Diabetes Hospital and Research Centre
Nashik, 422002, India
Lifepoint Multispeciality Hospital
Pune, 411057, India
Prabhu Diabetes Multi-Speciality Centre
Trichy, 620001, India
Adachi Kyosai Hospital
Adachi-ku, 120-0022, Japan
Nihonbashi Sakura Clinic
Chūōku, 103-0025, Japan
Medical Corporation Chiseikai Tokyo Center Clinic
Chūōku, 103-0027, Japan
Tokyo-Eki Center-building Clinic
Chūōku, 103-0027, Japan
Boocs Clinic Fukuoka
Fukuoka, 812-0025, Japan
Patient First Clinic Ginza-Shimbashi
Minato, 105-0004, Japan
Kanno Naika
Mitaka, 181-0013, Japan
Medical Corporation Heishinkai OCROM Clinic
Suita-shi, 565-0853, Japan
Higashi Shinjuku Clinic
Tokyo, 169-0072, Japan
Zdrowie Osteo-Medic
Bialystok, 15-351, Poland
Legeartis - Poradnie Specjalistyczne
Bialystok, 15-404, Poland
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
Krakow, 31-261, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
Lodz, 90-338, Poland
Gabinety TERPA
Lublin, 20-333, Poland
Ekamed
Lublin, 20-718, Poland
Centrum Zdrowia Metabolicznego Pawel Bogdanski
Poznan, 60-589, Poland
Pracownia Badań Klinicznych Salus
Wroclaw, 53-034, Poland
Samodzielny Publiczny Szpital Kliniczny nr 1 SUM
Zabrze, 41-800, Poland
Puerto Rico Health and Wellness Institute
Dorado, 00646, Puerto Rico
Wellness clinical Research Vega Baja
Vega Baja, 00693, Puerto Rico
Gachon University Gil Medical Center
Namdong-gu, 21565, South Korea
Konyang University Hospital
Seogu, 35365, South Korea
Seoul National University Bundang Hospital
Seongnam, 13620, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Pusan National University Yangsan Hospital
Yangsan, 50612, South Korea
Chiayi Christian Hospital
Chiayi City, 600, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, 83301, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Layton Medical Centre
Blackpool, FY3 7EN, United Kingdom
Bradford on Avon Health Centre
Bradford-on-Avon, BA15 1DQ, United Kingdom
Ashton Medical Group - Chapel House
Lancashire, OL6 6EW, United Kingdom
Royal Lancaster Infirmary
Lancaster, LA1 4RP, United Kingdom
Altnagelvin Area Hospital
Londonderry, BT47 6SB, United Kingdom
Bodyline Clinic - Openshaw
Manchester, M11 1AA, United Kingdom
Wansford Research Limited
Peterborough, PE8 6PL, United Kingdom
Abbeywell Surgery
Romsey, SO51 7QN, United Kingdom
Rame Group Practice
Torpoint, PL11 2TB, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Central Study Contacts
Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
CONTACT
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 5, 2026
First Posted
January 7, 2026
Study Start
February 6, 2026
Primary Completion (Estimated)
March 1, 2028
Study Completion (Estimated)
July 1, 2030
Last Updated
April 20, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.
- Access Criteria
- A research proposal should be approved by an independent review panel and researchers should sign a data sharing agreement.
Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.