Correlation of Oxygenation and Saturation Indices in One-Lung Ventilation

NCT07381517 | Not Yet Recruiting

• 1 other identifier: OLV-OXY-001
• Study Type: observational
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

One-lung ventilation is commonly used during thoracic surgery but is frequently associated with impaired oxygenation and altered respiratory mechanics. Traditional oxygenation indices require arterial blood gas analysis and do not fully reflect the mechanical stress applied to the lungs. This prospective observational study aims to evaluate the correlation between oxygenation indices and oxygen saturation indices during one-lung ventilation in adult patients undergoing elective thoracic surgery. Modified indices incorporating driving pressure and mechanical power will also be assessed. No intervention beyond standard clinical care will be applied. The findings of this study may help clarify the clinical utility of non-invasive oxygenation indices for intraoperative monitoring during one-lung ventilation.

Conditions

One-lung Ventilation (OLV)

Keywords

One-Lung Ventilation; Oxygenation; Oxygen Saturation Index; Driving Pressure; Mechanic Power; Thoracic Surgery

Outcome Measures

Primary Outcomes (1)

• Correlation between oxygenation indices and oxygen saturation indices

  Correlation between invasive oxygenation indices (oxygenation index and its derivatives) and non-invasive oxygen saturation indices (oxygen saturation index and its derivatives) measured during one-lung ventilation.

  During intraoperative one-lung ventilation

Study Arms (1)

One-Lung Ventilation Cohort

Adult patients undergoing elective thoracic surgery requiring one-lung ventilation. All patients will be managed according to standard clinical practice. No intervention is assigned as part of this observational study.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 18 years and older with ASA physical status I-III who are scheduled for elective thoracic surgery requiring intraoperative one-lung ventilation for at least one hour. All participants undergo standard perioperative management with simultaneous arterial blood gas analysis and continuous pulse oximetry monitoring during surgery.

You may qualify if:

• Patients aged 18 years and older
• Patients classified as ASA physical status I-III
• Patients scheduled for elective thoracic surgery requiring one-lung ventilation for at least 1 hour intraoperatively
• Patients in whom simultaneous arterial blood gas analysis and continuous SpO₂ monitoring can be performed
• Patients who have provided written informed consent

You may not qualify if:

• Patients undergoing emergency surgery
• Patients younger than 18 years of age
• Patients classified as ASA physical status IV or higher
• Patients with a history of previous thoracic surgery
• Patients with a body mass index (BMI) \>40 kg/m² or \<18 kg/m²
• Patients with advanced chronic lung disease (COPD stage III-IV)
• Patients with New York Heart Association (NYHA) class III-IV heart failure
• Patients undergoing surgery due to pleural effusion

Sponsors & Collaborators

• Ankara Ataturk Sanatorium Training and Research Hospital: lead

Study Sites (1)

Ankara Ataturk Sanatoryum Education and Research Hospital

Ankara, 06290, Turkey (Türkiye)

Location

Related Publications (3)

• Asar S, Rahim F, Rahimi P, Acicbe O, Tontu F, Cukurova Z. Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power. J Intensive Care Med. 2024 Jun;39(6):595-608. doi: 10.1177/08850666231223498. Epub 2024 Jan 5.

  PMID: 38179691 RESULT

• Chiumello D, Carlesso E, Cadringher P, Caironi P, Valenza F, Polli F, Tallarini F, Cozzi P, Cressoni M, Colombo A, Marini JJ, Gattinoni L. Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am J Respir Crit Care Med. 2008 Aug 15;178(4):346-55. doi: 10.1164/rccm.200710-1589OC. Epub 2008 May 1.

  PMID: 18451319 RESULT

• Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, Stewart TE, Briel M, Talmor D, Mercat A, Richard JC, Carvalho CR, Brower RG. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015 Feb 19;372(8):747-55. doi: 10.1056/NEJMsa1410639.

  PMID: 25693014 RESULT

Related Links

• Ankara Atatürk Sanatoryum Training and Research Hospital

Study Officials

• Onur KARSLIOĞLU

  Ankara Ataturk Sanatorium Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician in Anesthesiology

Study Record Dates

• First Submitted: January 25, 2026
• First Posted: February 2, 2026
• Study Start: February 9, 2026
• Primary Completion (Estimated): June 9, 2026
• Study Completion (Estimated): August 9, 2026
• Last Updated: February 2, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)