MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy
Added Value of MRI Volumetry and Diffusion Tensor Imaging Over Conventional MRI in Temporal Lobe Epilepsy
1 other identifier
observational
78
0 countries
N/A
Brief Summary
This works aims at evaluating the diagnostic performance of combined MRI Volumetry, Diffusion tensor imaging and Conventional MRI in lateralizing the epileptogenic focus in patients with temporal lobe epilepsy and correlate these findings with clinical outcome.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2026
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 12, 2026
CompletedFirst Posted
Study publicly available on registry
February 3, 2026
CompletedStudy Start
First participant enrolled
April 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 30, 2028
February 3, 2026
January 1, 2026
2.1 years
January 12, 2026
January 29, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Hippocampal mean diffusivity (MD) values measured by diffusion tensor imaging (DTI) in patients with temporal lobe epilepsy and non-epileptic control subjects.
Bilateral hippocampal MD values will be measured in square millimeters per second (mm²/s) by diffusion tensor imaging (DTI). MD value of the epileptogenic hippocampus will be compared with the contralateral side and with hippocampal MD values of age- and sex-matched control subjects.
Baseline
Interventions
MRI volumetry and Diffusion Tensor Imaging
Eligibility Criteria
Patients with idiopathic temporal lobe epilepsy and healthy volunteers
You may qualify if:
- Patients with different age groups having temporal lobe epilepsy diagnosed by EEG with no detected structural brain lesion by conventional MRI other than mesial temporal sclerosis.
You may not qualify if:
- Contraindications for MRI as claustrophobia, cardiac pacemaker and non-compatible metallic devices.
- Patients with suboptimal images or techniques.
- Post-operative and post-head traumatic cases.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (3)
Tajmirriahi M, Rabbani H. A Review of EEG-based Localization of Epileptic Seizure Foci: Common Points with Multimodal Fusion of Brain Data. J Med Signals Sens. 2024 Jul 25;14:19. doi: 10.4103/jmss.jmss_11_24. eCollection 2024.
PMID: 39234592BACKGROUNDSinha N. Localizing epileptogenic tissues in epilepsy: are we losing (the) focus? Brain. 2022 Nov 21;145(11):3735-3737. doi: 10.1093/brain/awac373.
PMID: 36412515BACKGROUNDVinti V, Dell'Isola GB, Tascini G, Mencaroni E, Cara GD, Striano P, Verrotti A. Temporal Lobe Epilepsy and Psychiatric Comorbidity. Front Neurol. 2021 Nov 30;12:775781. doi: 10.3389/fneur.2021.775781. eCollection 2021.
PMID: 34917019BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Target Duration
- 2 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- DR
Study Record Dates
First Submitted
January 12, 2026
First Posted
February 3, 2026
Study Start
April 1, 2026
Primary Completion (Estimated)
April 30, 2028
Study Completion (Estimated)
June 30, 2028
Last Updated
February 3, 2026
Record last verified: 2026-01