Role of Vessel Wall MRI in Differentiaition Between Intracranial Atherosclerotic Disease and Vasculitis as Causes of Ischemic Stroke

NCT07448454 | Not Yet Recruiting

• 1 other identifier: Vessel wall MRI
• Study Type: interventional
• Target: 46
• Locations: 0 countries
• Sites: N/A

Brief Summary

This work aims to clarify the diagnostic ability of vessel wall MRI to differentiate between intracranial atherosclerotic disease and vasculitis as causes of ischemic stroke, thereby guiding appropriate treatment and improving patient outcomes.

Conditions

Intracranial Atherosclerotic Disease (ICAD) and Vasculitis

Outcome Measures

Primary Outcomes (1)

• Role of vessel wall MRI in differentiation between intracranial atherosclerotic disease and vasculitis as causes of ischemic stroke by detection of eccentric or circumferential arterial wall thickening and pattern of postcontrast enhancement.

  Vessel wall MR sequences including T1 pre and post contrast in order to differentiate between intracranial atherosclerotic plaque and vasculitis and to assess atherosclerotic plaque activity by detection of eccentric or circumferential arterial wall thickening and pattern of postcontrast enhancement. According to previous studies, if there is enhancing eccenteric arterial wall thickening, it considered active athrosclerotic plaque, if there is non enhancing eccenteric aretrial wall thickening, it considered inactive atherosclerotic plaque. If there is enhancing circumferential arterial wall thickening, it considered vasculitis

  Baseline

Study Arms (1)

No Arms have been specified for this study.

OTHER

Device: MRI

Interventions

MRI DEVICE

Vessel wall MRI in differentiation between intracranial atherosclerotic disease and vasculitis as causes of ischemic stroke

No Arms have been specified for this study.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with ischemic stroke within 2 weeks from onset detected by magnetic resonance imaging (MRI) and have intracranial artery stenosis seen in magnetic resonance angiography (MRA).

You may not qualify if:

• Contraindications for MRI such as claustrophobia, heart pacemaker and ferromagnetic implants.
• Contraindications for contrast as patients with renal impairment.
• Patients in which the misaligned images or distortions due to motion artifacts made the interpretation of the MRI unreliable.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (9)

• Li F, Wang Y, Hu T, Wu Y. Application and interpretation of vessel wall magnetic resonance imaging for intracranial atherosclerosis: a narrative review. Ann Transl Med. 2022 Jun;10(12):714. doi: 10.21037/atm-22-2364.

  PMID: 35845481 BACKGROUND

• D'Aniello S, Rustici A, Gramegna LL, Godi C, Piccolo L, Gentile M, Zini A, Carrozzi A, Lodi R, Tonon C, Dall'Olio M, Simonetti L, Chieffo R, Anzalone N, Cirillo L. The Contribution of Vessel Wall Magnetic Resonance Imaging to the Diagnosis of Primary and Secondary Central Nervous System Vasculitis. Diagnostics (Basel). 2024 Apr 29;14(9):927. doi: 10.3390/diagnostics14090927.

  PMID: 38732340 BACKGROUND

• Hu T, Ling R, Zhu Y. Advancements in imaging of intracranial atherosclerotic disease: beyond the arterial lumen to the vessel wall. Rev Neurosci. 2024 Nov 19;36(3):229-241. doi: 10.1515/revneuro-2024-0076. Print 2025 Apr 28.

  PMID: 39565965 BACKGROUND

• Chaganti J, Woodford H, Tomlinson S, Dunkerton S, Brew B. Black blood imaging of intracranial vessel walls. Pract Neurol. 2020 Dec 29:practneurol-2020-002806. doi: 10.1136/practneurol-2020-002806. Online ahead of print.

  PMID: 33376151 BACKGROUND

• Mazzacane F, Mazzoleni V, Scola E, Mancini S, Lombardo I, Busto G, Rognone E, Pichiecchio A, Padovani A, Morotti A, Fainardi E. Vessel Wall Magnetic Resonance Imaging in Cerebrovascular Diseases. Diagnostics (Basel). 2022 Jan 20;12(2):258. doi: 10.3390/diagnostics12020258.

  PMID: 35204348 BACKGROUND

• Alzein MM, Patel A, Abdalla RN, Cantrell DR, Shaibani A, Ansari SA. MR Vessel Wall Imaging for Atherosclerosis and Vasculitis. Neuroimaging Clin N Am. 2024 May;34(2):251-260. doi: 10.1016/j.nic.2024.02.001.

  PMID: 38604709 BACKGROUND

• Edjlali M, Qiao Y, Boulouis G, Menjot N, Saba L, Wasserman BA, Romero JM. Vessel wall MR imaging for the detection of intracranial inflammatory vasculopathies. Cardiovasc Diagn Ther. 2020 Aug;10(4):1108-1119. doi: 10.21037/cdt-20-324.

  PMID: 32968663 BACKGROUND

• Tritanon O, Mataeng S, Apirakkan M, Panyaping T. Utility of high-resolution magnetic resonance vessel wall imaging in differentiating between atherosclerotic plaques, vasculitis, and arterial dissection. Neuroradiology. 2023 Mar;65(3):441-451. doi: 10.1007/s00234-022-03093-7. Epub 2022 Dec 2.

  PMID: 36456894 BACKGROUND

• Kang DW, Kim DY, Kim J, Baik SH, Jung C, Singh N, Song JW, Bae HJ, Kim BJ. Emerging Concept of Intracranial Arterial Diseases: The Role of High Resolution Vessel Wall MRI. J Stroke. 2024 Jan;26(1):26-40. doi: 10.5853/jos.2023.02481. Epub 2024 Jan 30.

  PMID: 38326705 BACKGROUND

MeSH Terms

Conditions

Vasculitis

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Mahmoud Abdelbaset Mahmoud, MSC

CONTACT

002 01121244528; mahmoudabdo5000@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Invistigator

Study Record Dates

• First Submitted: February 20, 2026
• First Posted: March 4, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: March 4, 2026

Record last verified: 2026-02