Value of Adding T2 Mapping Routine MRI in Assessment of Knee Articular Cartilage Early Osteoarthritis

NCT07316257 | Not Yet Recruiting

• 1 other identifier: T2 mapping in osteoarthritis
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis

Conditions

Osteearthritis; OA; OA Knee

Outcome Measures

Primary Outcomes (1)

• This work aims at elucidating the role of MRI complementary T2 mapping to measure the changes in T2 relaxation time of the articular knee cartilage in healthy group which there number will be 28 and pateints with early osteoarthritis there number 28

  to detect the value of adding T2 mapping to routine MRI in assessment of the articular cartilage in knee osteoarthritis

  baseline

Secondary Outcomes (1)

• This work aims at quantitive stratification of osteoarthrtic changes and its impact on treatement

  baseline

Interventions

MRI DEVICE

Device that use coil to image asses the articular cartilage of the knee

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

any patient with knee pain with no history of previous lustrophobiaoperation and has no metallic element inside his body with no ca

You may qualify if:

• patients with clinical evidence of osteoarthritis

You may not qualify if:

• contraindications for MRI such as claustrophobia, heart pacemaker and ferromagnetic implants
• patients in which the misaligned images or distortions due to motion artifacts made the interpretation of the MRI unreliable.
• Patients with previous knee operation

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Le J, Peng Q, Sperling K. Biochemical magnetic resonance imaging of knee articular cartilage: T1rho and T2 mapping as cartilage degeneration biomarkers. Ann N Y Acad Sci. 2016 Nov;1383(1):34-42. doi: 10.1111/nyas.13189. Epub 2016 Jul 29.

  PMID: 27472534 BACKGROUND

• Gao S, Peng C, Wang G, Deng C, Zhang Z, Liu X. Cartilage T2 mapping-based radiomics in knee osteoarthritis research: Status, progress and future outlook. Eur J Radiol. 2024 Dec;181:111826. doi: 10.1016/j.ejrad.2024.111826. Epub 2024 Nov 8.

  PMID: 39522425 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Abeer Houssein Ali, prof.dr

  Assiut University

  STUDY DIRECTOR

• Ahmed Moustafa Mohamed, prof

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Shrouk Mohamed Gad, MSC

CONTACT

+201028565525; shroukgad194@gmail.com

zahraa sayed hassan, MD

CONTACT

+201026816205; zahra.art@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: DR

Study Record Dates

• First Submitted: December 16, 2025
• First Posted: January 5, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): January 12, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: January 5, 2026

Record last verified: 2025-12