NCT07352319

Brief Summary

Eight-week interventional study to evaluate whether lower-body plyometric training alters serum creatine phosphokinase (CPK) and creatinine levels in female collegiate volleyball players. Sixty participants were randomized to experimental (plyometrics twice weekly) or control (routine volleyball) groups. Blood sampling occurred at baseline; days 2, 4, and 6; and weeks 1, 2, 4, 6, and 8.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 12, 2022

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 15, 2022

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 25, 2022

Completed
3.2 years until next milestone

First Submitted

Initial submission to the registry

January 11, 2026

Completed
9 days until next milestone

First Posted

Study publicly available on registry

January 20, 2026

Completed
Last Updated

January 20, 2026

Status Verified

January 1, 2026

Enrollment Period

4 months

First QC Date

January 11, 2026

Last Update Submit

January 11, 2026

Conditions

RhabdomyolysisExercise-Induced Muscle DamageAthletes

Outcome Measures

Primary Outcomes (1)

  • Serum CPK (U/L)

    change from baseline at day 2, day 4, week 1, week 2, week 4, week 6, week 8

    Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks

Secondary Outcomes (1)

  • Serum creatinine (mg/dL)

    Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks

Study Arms (2)

Lower-body plyometric training

EXPERIMENTAL

Progressive plyometric program, twice weekly for eight weeks.

Other: plyometric program

Control

ACTIVE COMPARATOR

Routine volleyball practice; no plyometric exercises.

Other: plyometric program

Interventions

plyometric programOTHER

Twice-weekly sessions (Mon/Wed) for 8 weeks; exercise menu and dosing per Table 1 (intensity, rest, and jumps/set).

Also known as: Lower-body plyometric training
ControlLower-body plyometric training

Eligibility Criteria

Age18 Years - 25 Years
Sexfemale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Active collegiate female volleyball players
  • consent to participate
  • no prior plyometric training program.

You may not qualify if:

  • Neuromuscular impairments
  • recent injuries.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dr. Mariam Salem

Jeddah, 32143, Saudi Arabia

Location

MeSH Terms

Conditions

Rhabdomyolysis

Condition Hierarchy (Ancestors)

Muscular DiseasesMusculoskeletal Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

January 11, 2026

First Posted

January 20, 2026

Study Start

January 12, 2022

Primary Completion

May 15, 2022

Study Completion

October 25, 2022

Last Updated

January 20, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Individual participant data will not be shared because this study does not include a data-sharing plan and is limited to internal analysis only.

Locations

SA(1)