Metabolic, Functional and Nutritional Responses to Weight Cycling in Athletes: The WAVE Study

NCT04107545 | Completed

• 2 other identifiers: RBHP 2019 DUCLOS2019-A00699-48
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Many elite athletes are submitted to frequent rapid weight loss periods to meet their competition weight category and then experience weight cycling (lowing and gaining weight regularly). This weight cycling induce severe temporary energetic and metabolic changes and when repeated over time can lead to permanent metabolic adaptations that might favor metabolic disorders, body weight gain and body composition changes (favoring fat mass). The exact effects of this weight cycling are not clear yet, especially in terms of metabolic, energetics, nutritional functional and psychological impacts. Better understand these adaptations and their variations during weight loss and weight gain in regular weight cycler is of main importance to prevent these athletes for future health issues. The aim of the present project if to assess these metabolic, functional, energetic and nutritional adaptations during weight loss, weight stable and weight gain periods in athletes experiencing regular weight cycling.

Conditions

Athletes

Keywords

weight cycling; sport; appetite; energy metabolism

Outcome Measures

Primary Outcomes (1)

• Change in Body temperature

  body temperature will be assessed using the bodyCap temperature monitor that records body temperature for up to 48h. this will be assessed for 24h on the three different phase (i) period of maintenance of body weight (CON); ii) two visits during weight loss (WL); iii) two visits during a weight regain (WG).)

  Day 1 , Day 60 , Day 90

Secondary Outcomes (13)

• Body fat mass

  Day 1 , Day 60 , Day 90

• Body fat free mass

  Day 1 , Day 60 , Day 90

• Food reward

  Day 1 , Day 60 , Day 90

• Basal Metabolic rate

  Day 1 , Day 60 , Day 90

• Cortisol

  Day 1 , Day 60 , Day 90

Study Arms (1)

athletes

EXPERIMENTAL

48 elite athletes, 24 men and 24 women, experiencing regular weight cycling.

Behavioral: athletes

Interventions

athletes BEHAVIORAL

Control of body temperature using the bodyCap temperature monitor that records body temperature for up to 48h (three times)

athletes

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subjects aged 18 to 35 (inclusive),
• exercising at least 4 sessions of endurance or weight-based sporting activities per week for a performance objective,
• having variations of at least 5% of their weight body during the last 3 sporting seasons (a sporting season corresponds to a year during which alternates the periods of training, recovery and participation in official competitions).
• Subject capable of providing informed consent to participate
• Subject with a social security insurance.

You may not qualify if:

• Medical or surgical history deemed by the investigator to be incompatible with the study.
• Presence of chronic pathology.
• Disorders of eating behavior.
• Subjects born very prematurely defined as a pregnancy inferior to 28 weeks.
• Subjects having used a treatment for a small stature (eg growth hormone).
• For women: irregular menstruation (changes in menstrual cycles ≥ 6 days).
• Sports subjects with a stable weight during the last three sporting seasons (weight variation \<5%).
• Take medication that can change body temperature.
• Pregnant or lactating women.
• Subjects with gastrointestinal complications and / or contraindications to ingestion of the capsule (eg diverticulosis, inflammatory bowel disease, gastrointestinal surgery ...).
• Subjects needing MRI during ingestion of the capsule or having a pacemaker or other implanted electro-medical device.
• Person under guardianship or not subject to a social security scheme.
• Refusal to sign the information and consent leaflet.
• Refusal of participation

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead
• Laboratoire AME2P: collaborator
• Université de Fribourg, Department of Endocrinology, Metabolism and Cardiovascular System: collaborator
• University of Leeds, Appetite Control and Energy Balance Research: collaborator

Study Sites (1)

Chu Clermont Ferrand

Clermont-Ferrand, 63003, France

Location

Related Publications (1)

• Bagot S, Ramos I, Miles-Chan J, Dulloo A, Hackney A, Boirie Y, Duclos M, Thivel D, Isacco L. The type of sport, but not sex, impacts body composition and metabolic response to a complete weight loss-weight regain episode in weight cycling athletes: results from the WAVE study. Appl Physiol Nutr Metab. 2025 Jan 1;50:1-13. doi: 10.1139/apnm-2024-0376.

  PMID: 39919268 DERIVED

MeSH Terms

Conditions

Weight Cycling

Interventions

Cardiomegaly, Exercise-Induced

Condition Hierarchy (Ancestors)

Weight Gain; Body Weight Changes; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Weight Loss

Intervention Hierarchy (Ancestors)

Cardiovascular Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Martine Duclos

  University Hospital, Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 20, 2019
• First Posted: September 27, 2019
• Study Start: May 3, 2021
• Primary Completion: December 12, 2023
• Study Completion: December 12, 2023
• Last Updated: March 8, 2024

Record last verified: 2024-03

Locations

FR (1)