Predicting of Frailty

NCT07332052 | Not Yet Recruiting

• 1 other identifier: 250066
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the frailty status of elderly patients undergoing surgery for hip fractures (femur trochanteric fractures). Since frailty is a critical factor in surgical outcomes and recovery, researchers want to find simple, fast, and objective ways to measure it. This study will investigate muscle thickness measured by ultrasound, handgrip strength measured by a dynamometer, and routine blood test values can accurately predict a patient's frailty level. If these objective methods are proven effective, it will help anesthesia and surgical teams manage the perioperative process more safely for high-risk elderly patients

Conditions

Femur Fractures; Frailty; Sarcopenia

Keywords

Geriatric Anesthesia; Frailty; Hip Fracture; Sarcopenia; Rectus Femoris

Outcome Measures

Primary Outcomes (1)

• Correlation between Rectus Femoris Muscle Thickness and Frailty Score

  Evaluation of the relationship between clinical frailty status (measured by the Clinical Frailty Scale) and objective muscle mass (measured as rectus femoris thickness in millimeters via ultrasonography). Over 5 point indicate frailty.

  Preoperative (within 24 hours before surgery)

Secondary Outcomes (3)

• Predictive Value of Handgrip Strength for Frailty

  Preoperative

• Correlation of Laboratory Biomarkers with Frailty Status

  1 day before operation

• Hematological Indicators of Frailty

  1 day before operation

Study Arms (1)

Elderly Hip Fracture Patients

Patients aged 65 and older who have been diagnosed with a trochanteric femur fracture and are scheduled for orthopedic surgery.

Other: Clinical and Functional Assessment; Other: Rectus femoris thickness measurement

Interventions

Clinical and Functional Assessment OTHER

Assessment of frailty status using the Clinical Frailty Scale and measurement of handgrip strength using a hand dynamometer (measured in kilograms). Ultrasonographic measurement of the rectus femoris muscle thickness (mm) and femur-skin distance (mm) conducted one day before surgery.

Also known as: Clinical Frailty Scale, Hand Dynamometry, Rectus Femoris Ultrasound, Sarcopenia Screening via Ultrasound

Elderly Hip Fracture Patients

Rectus femoris thickness measurement OTHER

By using ultrasound linear prob the thickness of rectus femoris muscle will be measured

Elderly Hip Fracture Patients

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of geriatric patients aged 65 years and older who have been hospitalized at the Orthopedics and Traumatology department of Mugla Sitki Kocman University Training and Research Hospital with a diagnosis of trochanteric femur fracture. This population includes patients scheduled for elective or semi-urgent orthopedic surgery who are capable of undergoing preoperative clinical and ultrasonographic assessments.

You may qualify if:

• Patients aged 65 years and older.
• Confirmed diagnosis of trochanteric femur fracture.
• Planned for orthopedic surgery under general or regional anesthesia.
• Ability to provide written informed consent (either by the patient or a legal representative).

You may not qualify if:

• Patients with advanced dementia or severe cognitive impairment who cannot cooperate with the handgrip strength test or Fried criteria questionnaire.
• Patients with terminal-stage diseases or those under palliative care.
• History of neuromuscular diseases or severe muscle-wasting conditions that affect the lower limbs (e.g., advanced muscular dystrophy).
• Patients with active infections or skin lesions at the site of ultrasound measurement (rectus femoris area).
• Emergency cases requiring immediate surgery where preoperative assessment cannot be completed.

Sponsors & Collaborators

• ali ihsan uysal: lead

Study Sites (1)

Muğla Sıtkı Koçman University Training and Research Hospital

Muğla, Menteşe, 48000, Turkey (Türkiye)

Location

Related Publications (3)

• Mehmet H, Yang AWH, Robinson SR. Measurement of hand grip strength in the elderly: A scoping review with recommendations. J Bodyw Mov Ther. 2020 Jan;24(1):235-243. doi: 10.1016/j.jbmt.2019.05.029. Epub 2019 May 24.

  PMID: 31987550 RESULT

• Sabatino A, Regolisti G, Bozzoli L, Fani F, Antoniotti R, Maggiore U, Fiaccadori E. Reliability of bedside ultrasound for measurement of quadriceps muscle thickness in critically ill patients with acute kidney injury. Clin Nutr. 2017 Dec;36(6):1710-1715. doi: 10.1016/j.clnu.2016.09.029. Epub 2016 Oct 1.

  PMID: 27743614 RESULT

• Saglam Oz M, Toprak B, Bora R, Demir I. The Role of Hematological Parameters in Critically Ill Patients: Mortality Prediction in Elderly Intensive Care Unit Patients. Cureus. 2025 Apr 13;17(4):e82183. doi: 10.7759/cureus.82183. eCollection 2025 Apr.

  PMID: 40364870 RESULT

MeSH Terms

Conditions

Femoral Fractures; Frailty; Sarcopenia; Hip Fractures

Condition Hierarchy (Ancestors)

Fractures, Bone; Wounds and Injuries; Leg Injuries; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Signs and Symptoms; Hip Injuries

Central Study Contacts

Ali İhsan Uysal, Ass.Prof

CONTACT

+905067020960; alihsanuysal@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Ass.Prof.

Study Record Dates

• First Submitted: December 30, 2025
• First Posted: January 12, 2026
• Study Start: January 20, 2026
• Primary Completion (Estimated): June 15, 2026
• Study Completion (Estimated): August 15, 2026
• Last Updated: January 12, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)