Postoperative Analgesic Efficacy Between Adductor Canal Block + IPACK Block and Adductor Canal Block + Genicular Nerve Block in Total Knee Arthroplasty

NCT07324486 | Not Yet Recruiting

• 1 other identifier: KonyaBeyhekimTRH2025/0115
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to compare the postoperative analgesic efficacy and functional outcomes of the IPACK+Adductor Canal Block with the Genicular Nerve Block+Adductor Canal Block block in patients undergoing total knee arthroplasty (TKA). The primary objective (measurable) is to evaluate functional improvement using 6-Clicks scores, while secondary objectives include pain scores (Vas Score), opioid consumption, hospital stay duration, and patient satisfaction (Patient Satisfaction Index). IPACK : The infiltration between the popliteal artery and capsule of the knee

Conditions

Total Knee Arthroplasty; Adductor Canal Block; Genicular Nerves Block; IPACK Block Multimodal Analgesia

Keywords

total knee arthroplasty; adductor canal block; genicular nerves block; IPACK

Outcome Measures

Primary Outcomes (1)

• 6-Clicks score

  Known as "6-Clicks" due to being composed of six scored patient activity questions, a patient's "6-Clicks" score falls on a 6- to 24-point scale where a score of 6 represents total functional impairment and a score of 24 represents total absence of impairment.

  6.,12.,24.,36.,48.,60.,72. hours

Secondary Outcomes (3)

• visual analog scale

  Postoperative recovery room 30 minutes and at 6., 12., 24., 36., 48., 60., and 72. hours

• total opioid consumption

  total opioid consumption 24.hour

• The Patient Satisfaction Index

  first 24. hour

Study Arms (2)

GROUP IPACK

OTHER

ADDUCTOR CANAL BLOCK + IPACK

Drug: Adductor Canal Block (ACB) + iPACK Block

GROUP GENİCULAR

EXPERIMENTAL

ADDUCTOR CANAL BLOCK + GENİCULAR BLOCK

Drug: adductor canal block + genicular blocks

Interventions

Adductor Canal Block (ACB) + iPACK Block DRUG

Patients who underwent total knee arthroplasty surgery with IPACK + adductor canal block , 25 patients. After the needle tip is placed in the target area between the popliteal artery and the femur, the local anesthetic solution (10 ml of 0.5% bupivacaine + 10 ml of physiological saline) is slowly injected after negative aspiration. After the needle tip is placed within the adductor canal, the local anesthetic solution (10 ml of 0.5% bupivacaine + 10 ml of physiological saline) is slowly injected after negative aspiration.

GROUP IPACK

adductor canal block + genicular blocks DRUG

Patients who underwent total knee arthroplasty surgery with genicular blocks + adductor canal block , 25 patients. The tip of the needle is directed toward the superior lateral, superior medial, and inferior medial genicular nerves under ultrasound guidance.2 ml of local anesthetic (0.5% bupivacaine) is injected into each nerve region. After the needle tip is placed into the adductor canal, the local anesthetic solution (10 ml of 0.5% bupivacaine + 10 ml of physiological saline) is slowly injected after negative aspiration.

GROUP GENİCULAR

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients scheduled for spinal anesthesia with TDA.
• Age ≥18.
• American Society of Anesthesiologists (ASA) physical status score I-III.
• Patients capable of providing informed consent.

You may not qualify if:

• Active infection at the injection site.
• Coagulopathy or systemic sepsis.
• Severe hypovolemia.
• Patients who refuse regional anesthesia.
• Known allergy to local anesthetics.
• Cognitive impairment or uncooperative patients.

Sponsors & Collaborators

• Konya Beyhekim Training and Research Hospital: lead

Central Study Contacts

Sami Uyar, Dr

CONTACT

+905379869085; uyarsami111191@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: single blind
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: December 10, 2025
• First Posted: January 7, 2026
• Study Start: December 15, 2025
• Primary Completion: January 30, 2026
• Study Completion: February 1, 2026
• Last Updated: January 7, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share