Dual Subsartorial Versus Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Patients Undergoing Total Knee Arthroplasty

NCT07082374 | Completed

• 1 other identifier: 36264PR1260/6/25
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the effect of dual subsartorial block (DSB), adductor canal block (ACB), and femoral nerve block (FNB) for postoperative analgesia in patients undergoing total knee arthroplasty (TKA).

Conditions

Dual Subsartorial Block; Adductor Canal Block; Femoral Nerve Block; Postoperative Analgesia; Total Knee Arthroplasty

Outcome Measures

Primary Outcomes (1)

• Time to the 1st rescue analgesia

  Time to the first request for the rescue analgesia (time from the end of surgery to first dose of morphine administrated).

  24 hours postoperatively

Secondary Outcomes (4)

• Intraoperative fentanyl consumption

  Intraoperatively

• Degree of pain

  24 hours postoperatively

• Degree of patient satisfaction

  24 hours postoperatively

• Incidence of adverse events

  24 hours postoperatively

Study Arms (3)

DSB group

EXPERIMENTAL

Patients will receive dual subsartorial block (DSB).

Other: Dual subsartorial block

ACB group

EXPERIMENTAL

Patients will receive an adductor canal block (ACB).

Other: Adductor canal block

FNB group

EXPERIMENTAL

Patients will receive a femoral nerve block (FNB).

Other: Femoral nerve block

Interventions

Dual subsartorial block OTHER

Patients will receive dual subsartorial block (DSB).

DSB group

Adductor canal block OTHER

Patients will receive an adductor canal block (ACB).

ACB group

Femoral nerve block OTHER

Patients will receive a femoral nerve block (FNB).

FNB group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age from 18 to 75 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.
• Undergoing total knee arthroplasty (TKA) under general anesthesia.

You may not qualify if:

• Severe valgus deformity.
• Acute/chronic kidney disease.
• Neurological deficit.
• Cognitive dysfunction.
• Local infection at the site of injection.
• Coagulopathy.
• Hypersensitivity and/or allergies to local anesthetic (LA) or any of the study medications.
• Chronic opioid consumption (daily or almost daily use of opioids for \> three months).
• Operative limb neuropathy.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: July 16, 2025
• First Posted: July 24, 2025
• Study Start: July 24, 2025
• Primary Completion: March 31, 2026
• Study Completion: March 31, 2026
• Last Updated: May 6, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)