Assessment of a Portable Digital Device for Quantified Analysis of Markerless Walking in Volunteers With Neuromuscular Diseases or Asymptomatic Volunteers

NCT07321977 | Recruiting

• 1 other identifier: Myokinesis
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

In recent years, knowledge of neuromuscular diseases has advanced considerably, and new therapeutic avenues are beginning to emerge. The proliferation of clinical trials has created a need to identify biomarkers that are both sensitive to changes and specific to the disease. Current gait tests only consider the time factor and not the evolution of the patient's biomechanics, which may prove insufficient for patients whose symptoms generally progress slowly. Quantifying gait parameters in neuromuscular patients therefore appears necessary. This is why we propose to study markerless gait analysis in this population, which would allow for simple and effective monitoring of kinematic parameters without resorting to complex equipment incompatible with routine clinical practice.

Conditions

Spinal Muscular Atrophy (SMA); Charcot-Marie-Tooth; Muscular Dystrophy; Myotonic Dystrophy

Keywords

gait analysis; neuromuscular; disease; markerless

Outcome Measures

Primary Outcomes (1)

• Vicon vs Myokinesis system correlation coefficient

  Correlation coefficient between measurements from the two systems in both groups, for spatiotemporal parameters and joint range of motion in the sagittal plane at the hip, knee, and ankle

  Day 1

Study Arms (1)

Volunteers with Neuromuscular disease or asymptomatic

OTHER

All participants have the same intervention. The intervention is to walk with shoes in a gait analysis room with VICON markers on the body. At the same time, the participant will be film by two smartphones to compare the kinematics and the spatio-temporal parameters between a marker-based and a markerless gait analysis.

Other: Gait analysis via video capture

Interventions

Gait analysis via video capture OTHER

Using motion analysis software integrated into a smartphone

Volunteers with Neuromuscular disease or asymptomatic

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• All volunteers
• Individuals under guardianship, curatorship, or legal protection
• Pregnant or breastfeeding women
• Non-ambulatory individuals
• Individuals with epilepsy
• Skin conditions preventing the placement of VICON motion sensors
• Asymptomatic volunteers
• Unstable respiratory or cardiac problems
• Neurological, musculoskeletal, or psychiatric problems
• Volunteers with a neuromuscular disease
• Recent trauma or serious falls (≤ 6 months)
• Individuals who have fallen more than twice in the past year and at least once in the past three months
• Use of assistive devices such as rigid knee braces or walkers
• Unstable cardiomyopathy
• Individuals awaiting diagnosis

Sponsors & Collaborators

• Institut de Myologie, France: lead

Study Sites (1)

Centre d'Exploration et d'Évaluation Neuromusculaire

Paris, France

RECRUITING

MeSH Terms

Conditions

Muscular Atrophy, Spinal; Charcot-Marie-Tooth Disease; Muscular Dystrophies; Myotonic Dystrophy; Disease

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Motor Neuron Disease; Neurodegenerative Diseases; Neuromuscular Diseases; Hereditary Sensory and Motor Neuropathy; Nervous System Malformations; Heredodegenerative Disorders, Nervous System; Polyneuropathies; Peripheral Nervous System Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Genetic Diseases, Inborn; Muscular Disorders, Atrophic; Muscular Diseases; Musculoskeletal Diseases; Myotonic Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Pauline SANTMARTY, MsC

CONTACT

+33 01 42 16 58 79; p.santmarty@institut-myologie.org

Romain FEIGEAN, PhD

CONTACT

+33 142166649; r.feigean@institut-myologie.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2025
• First Posted: January 7, 2026
• Study Start: January 5, 2026
• Primary Completion (Estimated): July 6, 2026
• Study Completion (Estimated): January 6, 2027
• Last Updated: January 7, 2026

Record last verified: 2026-01

Locations

FR (1)