Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?

NCT07312409 | Not Yet Recruiting

• 1 other identifier: Edgell Long COVID trial
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Millions have developed Long COVID (LC), and recent findings show an association between taurine deficiency (an amino acid) and symptoms in LC. Cost-effective and accessible interventions are needed to improve welfare and reduce healthcare costs. We will investigate the efficacy of 12-week taurine supplementation, on vascular function and the cardio/cerebrovascular responses to upright posture in LC. We will measure resting vascular function with EndoPAT and ultrasound, resting heart rate variability, and the blood pressure, heart rate, and brain blood flow response to 5 minutes of head-up tilt before and after 12-weeks of taurine supplementation in LC.

Conditions

Long COVID Syndrome

Keywords

Taurine; Vascular; Long COVID; Orthostatic; Cerebrovascular; Heart rate variability

Outcome Measures

Primary Outcomes (2)

• Orthostatic responses

  Measure cardiovascular and cerebrovascular responses to upright tilt using beat to beat blood pressure, ECG, and transcranial Doppler.

  Baseline and 12-week dietary supplementation.

• Vascular function

  Flow-mediated dilation and EndoPAT response. These techniques concurrently measure endothelial function using the same protocol.

  Baseline and 12-week dietary supplementation.

Secondary Outcomes (1)

• Heart rate variability

  Baseline and 12-week dietary supplementation.

Study Arms (1)

Taurine supplementation

EXPERIMENTAL

Participants will take 12-wks of taurine supplementation (2 x 675mg twice daily).

Dietary Supplement: Taurine supplementation

Interventions

Taurine supplementation DIETARY_SUPPLEMENT

Participants will take 12-wks taurine supplementation (2 x 675mg twice daily).

Taurine supplementation

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants will have had symptoms of Long COVID post-infection for at least 3 months

You may not qualify if:

• Inability to undergo tilt table testing for 5 minutes
• Inability to transport selves to York University from their homes
• Inability to speak English, or provide a translator
• Blood clotting disorders

Sponsors & Collaborators

• Canadian Institutes of Health Research (CIHR): collaborator
• York University: lead
• Long COVID Web: collaborator

Study Sites (1)

York University

Toronto, Ontario, M3J1P3, Canada

Location

Related Publications (11)

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MeSH Terms

Conditions

Post-Acute COVID-19 Syndrome

Condition Hierarchy (Ancestors)

COVID-19; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Heather Edgell, PhD

CONTACT

14167362100; edgell@yorku.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: All participants will receive the same treatment (i.e. taurine supplementation).

Study Record Dates

• First Submitted: December 17, 2025
• First Posted: December 31, 2025
• Study Start: April 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): March 31, 2027
• Last Updated: January 6, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)