Characteristics of Long COVID-19 Syndrome

NCT04793269 | Active Not Recruiting

• 1 other identifier: 2021-00280
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Characterization of patients with long COVID syndrome including symptoms, medical history and persistent organ damage.

Conditions

Long COVID Syndrome

Keywords

long COVID; post COVID

Outcome Measures

Primary Outcomes (6)

• Dyspnea

  modified medical research council (scale from 0 to 4). The higher the score the worse the symptoms.

  once through study completion, an average of 6 months.

• self-addressed Quality of life

  Short form health 36 questionnaire with 8 domains, each rated from 0-100. The higher the score the better subjective quality of life.

  once through study completion, an average of 6 months

• Thoracic pain

  assessed by medical interview (reported as yes or no)

  once through study completion, an average of 6 months

• Medical history

  List of relevant morbidities assessed as present/not present by medical interview (e.g. respiratory, cardial, neurological, psychiatric diseases by interview and medical records)

  once through study completion, an average of 6 months

• Fibrosis

  Assessed by chest CT, rated as present/not present

  once through study completion, an average of 6 months

• Myocardial damage

  Assessed by myocardial damage, rated as present/not present

  once through study completion, an average of 6 months

Study Arms (1)

Long COVID

Patients with long COVID syndrome

Other: No intervention

Interventions

No intervention OTHER

no intervention

Long COVID

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with long COVID syndrome

You may qualify if:

• Long COVID syndrome
• age \>= 18 years
• Informed consent

You may not qualify if:

• none

Sponsors & Collaborators

• Christian Clarenbach: lead

Study Sites (1)

University Hospital Zurich

Zurich, Canton of Zurich, 8091, Switzerland

Location

Related Publications (1)

• Malesevic S, Sievi NA, Baumgartner P, Roser K, Sommer G, Schmidt D, Vallelian F, Jelcic I, Clarenbach CF, Kohler M. Impaired health-related quality of life in long-COVID syndrome after mild to moderate COVID-19. Sci Rep. 2023 May 12;13(1):7717. doi: 10.1038/s41598-023-34678-8.

  PMID: 37173355 DERIVED

MeSH Terms

Conditions

Post-Acute COVID-19 Syndrome

Condition Hierarchy (Ancestors)

COVID-19; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Christian F Clarenbach, MD

  University Hospital Zurich, Pulmonology

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Sponsor Investigator

Study Record Dates

• First Submitted: March 4, 2021
• First Posted: March 11, 2021
• Study Start: February 23, 2021
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: March 30, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)