Taurine Supplementation Associated or Not With Exercise: Effect on Browning of White Adipose Tissue in Elderly Women With Sarcopenic Obesity

NCT05415176 | Unknown

• 1 other identifier: Taurine_exercise_browning
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The aging process is followed by metabolic and body composition changes, increasing the risk of obesity and sarcopenia. The coexistence of these conditions acts synergistically on each other and is known as sarcopenic obesity. Beige adipose tissue is a tissue type that emerges from subcutaneous white adipose tissue (WAT), altering its phenotype to resemble the thermogenic functions of brown adipose tissue (BAT) in response to beta-adrenergic stimuli. Some in vitro and animal studies suggest that taurine supplementation and physical exercise are effective interventions in stimulating the aforementioned tissue, promoting what is known as WAT darkening, improving energy metabolism and showing benefits on the maintenance of muscle mass via stimulation of the coactivating protein PGC1α. These investigations are scarce in humans and could help health professionals in the adjuvant treatment of sarcopenic obesity. Therefore, the aim of the present study is to analyze the effects of taurine supplementation associated or not with physical exercise on the darkening of the WAT in sarcopenic obese elderly women.

Conditions

Browning of Subcutaneous White Adipose Tissue Post Intervention; Metabolic and Inflammatory Variables Post Intervention

Keywords

Obesity; Sarcopenia; Brite adipose tissue; Taurine; Exercise

Outcome Measures

Primary Outcomes (1)

• Browning of white adipose tissue

  Changes in the gene and protein expression on the subcutaneous white adipose tissue

  16 weeks

Secondary Outcomes (11)

• Changes in metabolic parameters - fasting blood glucose

  16 weeks

• Changes in metabolic parameters - lipid profile

  16 weeks

• Changes in metabolic parameters - insulin sensitivity

  16 weeks

• Body composition changes

  16 weeks

• Improvement of physical performance

  16 weeks

Study Arms (4)

Taurine and Exercise (Tau+Exe)

EXPERIMENTAL

Individuals who will receive 3g of taurine supplementation combined with physical training in the period of 16 weeks

Dietary Supplement: Taurine supplementation; Other: Pshysical exercise

Taurine (Tau)

EXPERIMENTAL

Individuals who will receive 3g of taurine supplementation

Dietary Supplement: Taurine supplementation

Exercise (Exe)

EXPERIMENTAL

Individuals who will perform a physical training and receive a placebo supplementation in the period of 16 weeks

Other: Pshysical exercise

Placebo (Cont)

PLACEBO COMPARATOR

Individuals who will receive a placebo supplementation in the period of 16 weeks

Other: Placebo control

Interventions

Taurine supplementation DIETARY_SUPPLEMENT

Participants will receive 3g of taurine to be supplemented in the morning in single-dose capsules. The intervention will last 16 weeks.

Taurine (Tau); Taurine and Exercise (Tau+Exe)

Pshysical exercise OTHER

Participants will perform a multicomponent type workout that explores strength, aerobic and balance capacities with load progression every 15 days. The sessions will last 60 minutes each, being held three times a week with a day of rest in between. The intervention will last 16 weeks

Exercise (Exe); Taurine and Exercise (Tau+Exe)

Placebo control OTHER

The participants will receive a supplementation capsule containing placebo in the morning in single-dose capsules. The intervention will last 16 weeks.

Placebo (Cont)

Eligibility Criteria

• Age: 60 Years - 75 Years
• Gender Eligibility Details: Female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI between 30 and 40kg/m²;
• Appendicular lean mass below 15 kg;
• Dynamometry below the cutoff point adjusted for sex and BMI (less than or equal to 21kg);
• "Sit and stand" test below the cut-off point adjusted for the age group, considering the number of repetitions in 30 seconds;
• Present medical certificate to perform physical exercise

You may not qualify if:

• alcoholics
• smokers
• diseases that prevents the practice of physical activity
• medical impediment to the practice of physical exercise throughout the study
• infectious diseases
• coronary diseases
• chronic kidney diseases
• undergoing nutritional monitoring or weight loss treatment
• score ≤13 for cognitive screening on the Mini-Mental State Examination (MMSE)

Sponsors & Collaborators

• University of Sao Paulo: lead

Study Sites (1)

Escola de Educação Física e Esporte de Ribeirão Preto

Ribeirão Preto, São Paulo, 14040-907, Brazil

Location

MeSH Terms

Conditions

Obesity; Sarcopenia; Motor Activity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Behavior

Study Officials

• Ellen C de Freitas, PhD

  University of São Paulo, School of Physical Education and Sports of Ribeirão Preto Ph.D. +55 16 3602-0345 ellenfreitas@usp.br

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Randomized clinical trial.

Study Record Dates

• First Submitted: June 8, 2022
• First Posted: June 10, 2022
• Study Start: February 27, 2023
• Primary Completion: September 26, 2023
• Study Completion: June 1, 2024
• Last Updated: November 29, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)