Culturally Targeted Health Communication and Receptivity to the Human Papillomavirus Vaccine Among Parents in Flint, MI

NCT07301905 | Recruiting

• 1 other identifier: 00630245
• Study Type: interventional
• Target: 265
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if culturally targeted messaging about the human papillomavirus (HPV) increases receptivity to the HPV vaccine among African American parents of vaccine-eligible daughters. The main question it aims to answer is:

• Does culturally targeted messaging increase African American parents' intentions to vaccinate their daughter against HPV? Research will compare culturally targeted messaging to general, educational messaging and no messaging. Participants will:
• View culturally targeted messages, education-only messages, or no messages about the HPV vaccine
• Report their intentions to vaccinate their daughter against HPV
• Report whether they have initiated HPV vaccination for their daughter six months later

Conditions

HPV Vaccination

Outcome Measures

Primary Outcomes (6)

• HPV Vaccine Attitudes

  Subscale of Theory of Planned Behavior measuring attitudes toward the HPV vaccine on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate more positive attitudes

  Immediately following and 6-months post-health messaging

• HPV Vaccine Normative Beliefs

  Subscale of Theory of Planned Behavior measuring the extent to which participants believe other people are favorable toward the HPV vaccine on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate stronger normative beliefs

  Immediately following and 6-months post-health messaging

• HPV Vaccine Perceived Behavioral Control

  Subscale of Theory of Planned Behavior measuring beliefs about ability to vaccinate their child on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate greater perceived behavioral control

  Immediately following and 6-months post-health messaging

• HPV Vaccine Intentions

  Subscale of Theory of Planned Behavior measuring intentions to vaccinate their child on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate greater intentions

  Immediately following and 6-months post-health messaging

• Vaccination Initiation

  1 self-report item measuring whether parents' daughters have received at least one dose of the HPV vaccine since completion of the initial survey, with Yes/No response options

  6-months post-health messaging

• Vaccination Discussion

  1 self-report item measuring whether parents have discussed the HPV vaccine with their daughters' healthcare provider since completion of the initial survey, with Yes/No response options

  6-months post-health messaging

Secondary Outcomes (1)

• Anticipatory Racism

  Immediately following health messaging

Study Arms (5)

African American Culturally Targeted Messaging

EXPERIMENTAL

Culturally targeted messaging about the HPV vaccine for African American parents

Behavioral: Culturally Targeted HPV Vaccine Health Messaging

African American General, Education-Only Messaging

ACTIVE COMPARATOR

African American participants receive general, education-only messaging about the HPV vaccine.

Behavioral: General HPV Vaccine Health Messaging

African American No Message

NO INTERVENTION

African American participants receive no messaging about the HPV vaccine

White General, Education-Only Messaging

ACTIVE COMPARATOR

White participants receive general, education-only messaging about the HPV vaccine.

Behavioral: General HPV Vaccine Health Messaging

White No Message

NO INTERVENTION

White participants receive no messaging about the HPV vaccine

Interventions

General HPV Vaccine Health Messaging BEHAVIORAL

General, education-only messaging about the HPV vaccine does not include culturally targeted messaging.

African American General, Education-Only Messaging; White General, Education-Only Messaging

Culturally Targeted HPV Vaccine Health Messaging BEHAVIORAL

Educational messaging about the HPV vaccine includes culturally targeted messaging about the HPV vaccine.

African American Culturally Targeted Messaging

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Identify as Black/African American or White/Caucasian
• Have at least one daughter who is between 8-17 years of age, who is not currently pregnant, and who has not received any doses of the HPV vaccine

You may not qualify if:

• N/A

Sponsors & Collaborators

• Michigan State University: lead

Study Sites (1)

Flint Journal Building

Flint, Michigan, 48502, United States

RECRUITING

Central Study Contacts

Olivia Aspiras, PhD

CONTACT

810-600-9181; aspiraso@msu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants will be unaware of their assignment to a general, education-only versus culturally targeted messaging condition.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: This research will use a 2 (White, African American) x 3 (No message, Education-only message, Culturally targeted message) quasi-experimental design. All participants will be randomly assigned to a no-message control group or to receive educational materials about HPV vaccination. Half of African American parents who receive educational materials will also view culturally targeted messaging about the HPV vaccine.

Study Record Dates

• First Submitted: September 8, 2025
• First Posted: December 24, 2025
• Study Start: November 17, 2024
• Primary Completion: June 1, 2026
• Study Completion: June 1, 2026
• Last Updated: March 13, 2026

Record last verified: 2025-11

Locations

US (1)