Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation

NCT07297823 | Not Yet Recruiting

• 1 other identifier: 7231
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.

Conditions

Exercise

Keywords

exercise; fat; temperature; cold; metabolism

Outcome Measures

Primary Outcomes (1)

• Maximal Fat Oxidation

  Using indirect calorimetry, fat oxidation will be determined. The maximal value for fat oxidation will be recorded.

  During exercise while in the lab

Study Arms (2)

Exercise at room temperature

ACTIVE COMPARATOR

Study participants will ride an exercise bike

Other: Room Temperature

Exercise at cold temperature

EXPERIMENTAL

Study participants will ride an exercise bike. Room temperature will be 5 ºC

Other: Cold temperature

Interventions

Room Temperature OTHER

Exercise condition for control arm

Exercise at room temperature

Cold temperature OTHER

Room temperature will be decreased to 5 ºC

Exercise at cold temperature

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-40 years (inclusive)
• Weight stable (no change in body mass greater than 5 lbs. within the previous 6 months.
• Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
• Competency in English as informally assessed by comprehension of the Informed Consent. This study involves maximal exercise testing; for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.
• Regular exercise (i.e., at least 150 minutes of moderate-vigorous exercise per week)

You may not qualify if:

• Use of hormonal contraceptives
• History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
• Pregnancy or breast feeding
• Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)

Sponsors & Collaborators

• Colorado State University: lead

MeSH Terms

Conditions

Motor Activity; Platelet Glycoprotein IV Deficiency; Common Cold

Interventions

Cold Temperature

Condition Hierarchy (Ancestors)

Behavior; Respiratory Tract Infections; Infections; Picornaviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Temperature; Thermodynamics; Physical Phenomena; Weather; Atmosphere; Environment; Ecological and Environmental Phenomena; Biological Phenomena; Meteorological Concepts; Environment and Public Health

Study Officials

• Christopher Bell

  Colorado State University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christopher Bell

CONTACT

9704917522; Christopher.Bell@colostate.edu

Christina Cheng

CONTACT

9704913495; c.cheng@colostate.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2025
• First Posted: December 22, 2025
• Study Start: January 31, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): June 30, 2027
• Last Updated: December 26, 2025

Record last verified: 2025-12