The Effect of Continuous Low Tidal Volume Ventilation During Cardiopulmonary Bypass on Renal Resistive Index

NCT07044102 | Completed

• 1 other identifier: bypass surgery
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative acute kidney injury following cardiopulmonary bypass surgery represents a significant barrier to patient recovery and is closely associated with increased postoperative morbidity and mortality. Studies have shown that the incidence of AKI aftercardiopulmonary bypass surgeryranges between 5% and 30%. The Renal Resistive Index, measured by Doppler ultrasonography, is an increasingly utilized parameter that provides valuable insights into renal hemodynamics and vascular resistance. A normal RRI is typically below 0.70; elevated values may indicate increased renal vascular resistance or microvascular damage. Bossard et al. demonstrated that increased RRI in the early postoperative period is associated with the development of AKI. Early evaluation of renal blood flow thus facilitates prompt detection of AKI. Both preoperative and postoperative RRI measurements are considered useful tools for identifying early renal dysfunction. Monitoring RRI before and after CABG may provide critical information for preventing postoperative renal complications.

Conditions

Postoperative Complications

Outcome Measures

Primary Outcomes (1)

• Renal resistive ındex

  Measurement of Changes in Renal Resistive Index Associated With Low Tidal Volume and Apneic Ventilation

  Postoperative 45 minutes

Study Arms (2)

Patients Undergoing Low Tidal Volume Ventilation During CABG

EXPERIMENTAL

patients undergoing coronary artery bypass grafting receive continuous low tidal volume ventilation during cardiopulmonary bypass

Other: Patients Undergoing Low Tidal Volume Ventilation During CABG

Patients Managed With Apneic Ventilation During Cardiopulmonary Bypass"

ACTIVE COMPARATOR

patients undergoing coronary artery bypass grafting are managed with apnea ventilation during cardiopulmonary bypass

Other: Patients Undergoing Apneic Ventilation During CABG

Interventions

Patients Undergoing Low Tidal Volume Ventilation During CABG OTHER

Postoperative Evaluation of Renal Resistive Index Using Doppler Ultrasound After Cardiopulmonary Bypass

Patients Undergoing Low Tidal Volume Ventilation During CABG

Patients Undergoing Apneic Ventilation During CABG OTHER

Postoperative Evaluation of Renal Resistive Index Using Doppler Ultrasound After Cardiopulmonary Bypass"

Patients Managed With Apneic Ventilation During Cardiopulmonary Bypass"

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients scheduled for elective cardiac bypass surgery
• Male and female patients over 18 years of age
• Patients with an American Society of Anesthesiologists (ASA) physical status classification of II, III, or IV

You may not qualify if:

• Chronic renal failure requiring dialysis
• Patients requiring emergency surgery

Sponsors & Collaborators

• Konya City Hospital: lead

Study Sites (1)

Konya City Hospital

Konya, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Postoperative Complications

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist Doctor, MD Anesthesiology and Reanimation

Model Details: participants are randomized in a parallel design to receive either continuous low tidal volume ventilation or conventional ventilation during cardiopulmonary bypass

Study Record Dates

• First Submitted: June 23, 2025
• First Posted: June 29, 2025
• Study Start: July 15, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: February 4, 2026

Record last verified: 2026-02

Locations

TU (1)