IL-6 and Hemogram-Derived Inflammatory Indices for Mortality Prediction in Postoperative ICU Patients

NCT07460141 | Recruiting

• 1 other identifier: TrabzonMFA
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational cohort study aims to evaluate the predictive value of interleukin-6 (IL-6) levels and hemogram-derived inflammatory scores for morbidity and in-hospital mortality in postoperative patients admitted to the intensive care unit (ICU). IL-6 levels and inflammatory indices will be assessed at ICU admission and at 24 hours using data obtained from routine clinical care. Associations between these biomarkers and clinical outcomes, including mortality, morbidity, antibiotic use, and duration of mechanical ventilation, will be evaluated after adjustment for illness severity.

Conditions

Postoperative Complications; Critical Illness; Inflammation; Intensive Care Unit Admission

Keywords

Interleukin-6; IL-6; Inflammatory indices; Postoperative; Intensive care; Mortality; Biomarkers

Outcome Measures

Primary Outcomes (2)

• In-hospital mortality (all-cause)

  In-hospital all-cause mortality within 28 days of intensive care unit admission, assessed using routinely collected clinical data.

  Within 28 days of ICU admission

• Postoperative morbidity

  Postoperative morbidity within 28 days of intensive care unit admission. Postoperative morbidity includes sepsis defined according to Sepsis-3 criteria and acute kidney injury defined according to KDIGO criteria, assessed using routinely collected clinical data.

  Within 28 days

Secondary Outcomes (4)

• Antibiotic use

  Within 28 days

• Duration of mechanical ventilation

  Within 28 days

• ICU length of stay

  Within 28 days

• Infectious complications / sepsis

  Within 28 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult postoperative patients (aged 18 years and older) admitted to the intensive care unit. Patients are enrolled prospectively and followed using routinely collected clinical and laboratory data obtained at ICU admission and at 24 hours. Cardiac and thoracic surgery patients are excluded.

You may qualify if:

• Age ≥ 18 years
• Postoperative patients admitted to the ICU
• Availability of complete clinical and laboratory data at ICU admission and at 24 hours
• Provision of informed consent by the patient or legally authorized representative

You may not qualify if:

• Age \< 18 years
• Thoracic surgery patients
• Cardiac surgery patients

Sponsors & Collaborators

• Ezgi Günaydın: lead

Study Sites (1)

Recep Erin

Trabzon, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Postoperative Complications; Critical Illness; Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Disease Attributes

Central Study Contacts

Ezgi Günaydın, MD

CONTACT

+905336834198; ezgunaydin@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: research assistant

Study Record Dates

• First Submitted: March 4, 2026
• First Posted: March 10, 2026
• Study Start: December 15, 2025
• Primary Completion: March 15, 2026
• Study Completion: March 15, 2026
• Last Updated: March 10, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)