NCT07276347

Brief Summary

The aim of this study is to assess contact lens performance and acceptance.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
36

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 12, 2025

Completed
19 days until next milestone

First Submitted

Initial submission to the registry

December 1, 2025

Completed
10 days until next milestone

First Posted

Study publicly available on registry

December 11, 2025

Completed
6 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 17, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 17, 2025

Completed
Last Updated

April 13, 2026

Status Verified

April 1, 2026

Enrollment Period

1 month

First QC Date

December 1, 2025

Last Update Submit

April 9, 2026

Conditions

HyperopiaMyopia

Outcome Measures

Primary Outcomes (1)

  • High contrast, high luminance binocular distance visual acuity

    High contrast, high luminance binocular distance visual acuity (logMAR) will be measured at 10-hour visit.

    At the end of 10 hours of daily wear at dispensing

Study Arms (13)

somofilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: somofilcon A lens

stenfilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: stenfilcon A lens

fanfilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: fanfilcon A lens

comfilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: comfilcon A lens

verofilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: verofilcon A lens

serafilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: serafilcon A lens

lehfilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: lehfilcon A lens

delefilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: delefilcon A lens

senofilcon A lens daily disposable

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: senofilcon A daily disposable lens

senofilcon A lens with blue light technology

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: senofilcon A with blue light technology lens

senofilcon A lens bi-weekly replacement

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: senofilcon A bi-weekly lens

samfilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: samfilcon A lens

kalifilcon A lens

EXPERIMENTAL

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types.

Device: kalilfilcon A lens

Interventions

somofilcon A lensDEVICE

Participants will be randomized to wear somofilcon A soft contact lens for 10 hours.

somofilcon A lens
fanfilcon A lensDEVICE

Participants will be randomized to wear fanfilcon A soft contact lens for 10 hours.

fanfilcon A lens
comfilcon A lensDEVICE

Participants will be randomized to wear comfilcon A soft contact lens for 10 hours.

comfilcon A lens
verofilcon A lensDEVICE

Participants will be randomized to wear verofilcon A soft contact lens for 10 hours.

verofilcon A lens
serafilcon A lensDEVICE

Participants will be randomized to wear serafilcon A soft contact lens for 10 hours.

serafilcon A lens
senofilcon A daily disposable lensDEVICE

Participants will be randomized to wear senofilcon A soft contact lens for 10 hours.

senofilcon A lens daily disposable
senofilcon A with blue light technology lensDEVICE

Participants will be randomized to wear senofilcon A soft contact lens for 10 hours.

senofilcon A lens with blue light technology
senofilcon A bi-weekly lensDEVICE

Participants will be randomized to wear senofilcon A soft contact lens for 10 hours.

senofilcon A lens bi-weekly replacement
stenfilcon A lensDEVICE

Participants will be randomized to wear stenfilcon A soft contact lens for 10 hours.

stenfilcon A lens
lehfilcon A lensDEVICE

Participants will be randomized to wear lehfilcon A soft contact lens for 10 hours.

lehfilcon A lens
delefilcon A lensDEVICE

Participants will be randomized to wear delefilcon A soft contact lens for 10 hours.

delefilcon A lens
samfilcon A lensDEVICE

Participants will be randomized to wear samfilcon A soft contact lens for 10 hours.

samfilcon A lens
kalilfilcon A lensDEVICE

Participants will be randomized to wear kalifilcon A soft contact lens for 10 hours.

kalifilcon A lens

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Age 18 to 45 years (inclusive)
  • Habitual soft spherical contact lens wearer (current prescription)
  • Refractive error of -6.00 to -0.50DS or +0.50 to +6.00DS and less than or equal to 0.75DC as vertexed to the corneal plane
  • Anisometropia no greater than 1.50D, based on vertexed manifest refraction spherical equivalent
  • Can achieve visual acuity of at least 20/25 in each eye with spherical equivalent manifest refraction

You may not qualify if:

  • Active anterior segment infection, inflammation or abnormality that would contraindicate contact lens wear
  • Use of systemic or ocular medication that would contraindicate contact lens wear
  • Used gas permeable/hard contact lenses (including orthokeratology) in the previous 3 months
  • Participation in a contact lens or lens care product trial in the previous 30 days

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Indiana University

Bloomington, Indiana, 47405, United States

Location

MeSH Terms

Conditions

HyperopiaMyopia

Condition Hierarchy (Ancestors)

Refractive ErrorsEye Diseases

Study Officials

  • Pete Kollbaum, OD, PhD

    Indiana University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 1, 2025

First Posted

December 11, 2025

Study Start

November 12, 2025

Primary Completion

December 17, 2025

Study Completion

December 17, 2025

Last Updated

April 13, 2026

Record last verified: 2026-04

Locations

US(1)