A Prospective Cohort Study on Patient With Obesity Undergoing Weight Change

NCT07239167 | Enrolling By Invitation

• 1 other identifier: 202504134RINA
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective cohort study collected baseline data and followed up obese patients at their first visit to a weight loss clinic. The study examined the impact of various predictors and biomarkers on weight loss outcomes, aiming to establish an evidence-based foundation for personalized weight loss treatment. Participants underwent a battery of measurements and questionnaires, including height, weight, waist circumference, blood pressure, blood tests, and questionnaires addressing diet, exercise, stress, sleep, measure handgrip strength ,and psychological well-being.

Conditions

Obesity & Overweight; Weight Loss; Metabolic Syndrome; Metabolic Dysfunction-Associated Steatohepatitis; Obesity (Disorder)

Outcome Measures

Primary Outcomes (1)

• Baseline data were collected and followed up during the subjects' initial visit to the weight loss clinic to establish an evidence-based basis for personalized weight reduction treatment.

  Weight changes of subjects after 24 weeks, 48 weeks, 72 weeks, and 96 weeks.

Study Arms (1)

A prospective cohort study on patients with obesity undergoing weight change

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participate were first diagnosed at the weight loss clinic at the National Taiwan University Hospital.

You may qualify if:

• Adults aged 18 years or older, regardless of gender.
• Body mass index (BMI) ≥ 27 kg/m², or ≥ 24 kg/m² with one or more obesity-related comorbidities.
• Willing to undergo any form of weight loss intervention.
• Able to read and understand Chinese, willing to complete questionnaires, blood tests, and follow-up follow-up.
• Voluntarily consent to participate and be willing to complete the subject consent form.

You may not qualify if:

• Pregnant or breastfeeding women.
• Individuals with significant mental illness (e.g., schizophrenia, severe depression) or cognitive impairment that may affect their ability to consent or cooperate with the study.
• Individuals with severe organ dysfunction (e.g., end-stage renal disease, cirrhosis, congestive heart failure, etc.).
• Individuals taking medications that significantly affect their weight (e.g., long-term steroids or antipsychotics) and cannot be discontinued.
• Individuals deemed unsuitable for participation in this study by the study leader (e.g., individuals who are expected to be unable to complete follow-up).

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

No.7, Chung Shan S. Rd.（Zhongshan S. Rd.）

Taipei, Zhongzheng Dist, 100, Taiwan

Location

MeSH Terms

Conditions

Obesity; Overweight; Weight Loss; Metabolic Syndrome

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Weight Changes; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 16, 2025
• First Posted: November 20, 2025
• Study Start: June 5, 2025
• Primary Completion (Estimated): April 8, 2027
• Study Completion (Estimated): May 5, 2035
• Last Updated: March 30, 2026

Record last verified: 2025-06

Locations

TW (1)