Metabolic Syndrome and Prediabetes

NCT07243821 | Recruiting

• 1 other identifier: 202509097RINB
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to establish a cohort of individuals with metabolic syndrome and prediabetes to enable long-term follow-up of risk factors, disease progression, and the development of obesity-related complications. The study will also monitor changes in nutritional status and physical function over time, in order to identify key prognostic determinants influencing clinical outcomes. Metabolic syndrome and prediabetes are chronic multisystem disorders, and poor long-term control is closely associated with the development of various complications. Moreover, malnutrition and functional decline are common comorbid conditions that further impair quality of life and impose a substantial burden on healthcare resources.

Conditions

Metabolic Syndrome; Diabetes

Keywords

Obesity; Nutrition; Physical activity; Diabetes; Body composition; Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• Medical record system and on-site inspection data collection

  Everytime after physician's appointment(Usually 3 months).

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

articipants eligible for inclusion are adults aged 18 years or older who have been clinically diagnosed with either metabolic syndrome or prediabetes. Metabolic syndrome is defined by the presence of at least three of the following five criteria: (A) waist circumference ≥ 90 cm in men or ≥ 80 cm in women, or a body mass index (BMI) ≥ 27 kg/m²; (B) fasting plasma glucose ≥ 100 mg/dL; (C) systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg; (D) triglycerides ≥ 150 mg/dL; and (E) high-density lipoprotein cholesterol (HDL-C) \< 40 mg/dL in men or \< 50 mg/dL in women. Participants meeting the definition of prediabetes, defined as glycated hemoglobin (HbA1c) levels between 5.7% and 6.4%, will also be eligible. All participants must be willing to join the study, provide written informed consent, and be able to complete basic physical examinations and assessment procedures.

You may qualify if:

• Adults aged 18 years or older.
• Individuals clinically diagnosed by a physician as having metabolic syndrome (meeting at least three of the following five criteria) or prediabetes:
• (A) Waist circumference: ≥ 90 cm in men or ≥ 80 cm in women, or body mass index (BMI) ≥ 27 kg/m².
• (B) Fasting plasma glucose (AC): ≥ 100 mg/dL. (C) Blood pressure: Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg.
• (D) Triglycerides (TG): ≥ 150 mg/dL. (E) High-density lipoprotein cholesterol (HDL-C): \< 40 mg/dL in men or \< 50 mg/dL in women.
• Individuals meeting the definition of prediabetes, defined as glycated hemoglobin (HbA1c) between 5.7% and 6.4%.
• Participants who are willing to participate in the study and have signed written informed consent.
• Participants who are able to complete basic physical examinations and assessment procedures.

You may not qualify if:

• Individuals unable to comprehend the study information or procedures.
• Individuals unable to comply with the required assessments or study protocols.
• Any other condition that, in the clinical judgment of the principal investigator, deems the individual unsuitable for participation.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Zhongzheng Dist, 100229, Taiwan

RECRUITING

MeSH Terms

Conditions

Metabolic Syndrome; Diabetes Mellitus; Obesity; Motor Activity

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Chia-Wen Lu, Present Professor

  Department of Family Medicine, National Taiwan University Hospital

  STUDY CHAIR

Central Study Contacts

Chia-Wen Lu, Present Professor

CONTACT

886-2-23123456; biopsycosocial@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: November 24, 2025
• Study Start: October 31, 2025
• Primary Completion (Estimated): September 1, 2028
• Study Completion (Estimated): September 1, 2028
• Last Updated: November 24, 2025

Record last verified: 2025-10

Locations

TW (1)