Weight Loss and Adipose Tissue Metabolism During Conservative Treatment of Obesity

NCT07456124 | Completed

• 1 other identifier: HUS71/13/03/01/14
• Study Type: observational
• Target: 22
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective observational study investigates weight loss and metabolic changes in adults with obesity undergoing standard clinical diet-induced lifestyle treatment and counseling. Participants follow a very-low-calorie diet followed by a conventional weight loss diet in addition to lifestyle counseling and are followed for 12 months. The study examines weight loss as the primary outcome and characterizes changes in body composition, fat distribution, glucose metabolism, inflammation, and adipose tissue biology as secondary outcomes.

Conditions

Obesity & Overweight; Obesity (Disorder)

Keywords

Weight loss; obesity; adipose tissue; inflammation; mitochondria; metabolism; conservative treatment of obesity; lifestyle intervention of obesity

Outcome Measures

Primary Outcomes (1)

• Percent Total Body Weight Loss (%TWL)

  Percentage change in body weight from baseline, calculated as 100 × (baseline weight - follow-up weight) / baseline weight

  Baseline to 6 months

Secondary Outcomes (14)

• Change in Body Weight (kg)

  Baseline to 6 and to 12 months

• Change in Total Body Fat Mass (kg)

  Baseline to 6 months and to 12 months

• Change in Body Fat percentage (%)

  Baseline to 6 and to 12 months

• Change in Plasma Glycated Hemoglobin (HbA1c)

  Baseline to 6 months and to 12 months

• Change in HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

  Baseline to 6 and to 12 months

Study Arms (1)

Diet-Induced Weight Loss Cohort

Adults with obesity undergoing standard clinical diet treatment including a very-low-calorie diet followed by transition to a conventional weight loss diet and lifestyle counseling

Behavioral: Diet-Induced Weight Loss Program

Interventions

Diet-Induced Weight Loss Program BEHAVIORAL

Standard clinical obesity treatment consisting of a very-low-calorie diet for approximately 10 weeks followed by transition to a conventional weight loss diet with multidisciplinary clinical follow-up.

Diet-Induced Weight Loss Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients seeking treatment for obesity at Helsinki University Central Hospital and affiliated outpatient obesity clinics.

You may qualify if:

• Age ≥18 years
• BMI ≥28 kg/m²
• Seeking treatment for obesity at Helsinki University Central Hospital or affiliated units

You may not qualify if:

• Pregnancy or lactation
• Current smoking
• Anemia (Hb \<130 g/L in men; \<120 g/L in women)
• Severe comorbid disease or condition judged by investigator to compromise safety
• Contraindications to MRI (e.g., metal implants, claustrophobia)

Sponsors & Collaborators

• University of Helsinki: lead

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, plasma, serum, subcutaneous adipose tissue in four depots

MeSH Terms

Conditions

Obesity; Overweight; Weight Loss; Inflammation

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Weight Changes; Pathologic Processes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Docent in Experimental Internal Medicine

Study Record Dates

• First Submitted: January 21, 2026
• First Posted: March 6, 2026
• Study Start: August 19, 2014
• Primary Completion: August 17, 2016
• Study Completion: August 17, 2016
• Last Updated: March 6, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share