NCT07292389

Brief Summary

The purpose of this research study is to learn how to identify the most effective ways to provide weekly feedback on participants' progress toward intervention goals during a weight loss program.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
127

participants targeted

Target at P50-P75 for not_applicable

Timeline
13mo left

Started Mar 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress10%
Mar 2026Jun 2027

First Submitted

Initial submission to the registry

December 5, 2025

Completed
13 days until next milestone

First Posted

Study publicly available on registry

December 18, 2025

Completed
3 months until next milestone

Study Start

First participant enrolled

March 23, 2026

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2027

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2027

Last Updated

March 31, 2026

Status Verified

March 1, 2026

Enrollment Period

1.1 years

First QC Date

December 5, 2025

Last Update Submit

March 30, 2026

Conditions

Keywords

weight lossself-monitoringsmartphone applifestyle interventiondigital healthphysical activitydietary changee-scalewearablesactivity monitorbehavior changeself-monitor activity

Outcome Measures

Primary Outcomes (1)

  • Weight change

    Mixed-effects models will be used to investigate the impact of each feedback condition on our primary outcome of weight change. Fitted model estimates will be used to calculate the slope of weight change from day 1 (the day a feedback message is delivered) through day 7 of each week. Positive slopes indicate weight gain, while negative slopes indicate weight loss.

    7 days

Secondary Outcomes (7)

  • Frequency of self-monitoring weight

    7 days

  • Frequency of self-monitoring dietary intake

    7 days

  • Total caloric intake

    7 days

  • Calorie goal attainment

    7 days

  • Frequency of self-monitoring physical activity

    7 days

  • +2 more secondary outcomes

Study Arms (1)

Self Monitoring Feedback

EXPERIMENTAL

Participants in this study will complete a 60-minute "Weight Loss 101" session and use study-provided tools to record their daily food intake, physical activity, and weight. After a one-week run-in period, they will begin receiving weekly feedback messages. The content and emphasis of these messages will differ between 2 conditions: positive reinforcement vs. positive reinforcement + areas for change.

Behavioral: Positive ReinforcementBehavioral: Positive Reinforcement + Areas for Change

Interventions

Feedback composed by a study interventionist that focuses exclusively on positively reinforcing the participant's progress toward achieving their goals.

Self Monitoring Feedback

Feedback provided by a study interventionist that combines positive reinforcement of the participant's progress with constructive guidance on areas for improvement to support successful goal attainment.

Self Monitoring Feedback

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age greater than or equal to 18 years
  • BMI greater than or equal to 25.0 kg/m2
  • Weight less than or equal to 175 kg (due to scale limit)
  • Own a smartphone compatible with Fitbit (e.g., an Apple iPhone running iOS 16.4 or higher or Android smartphone running Android 11 or higher) with a cellular and data plan

You may not qualify if:

  • Weight greater than 175 kg (due to a weight limit of the study-provided scale)
  • Smartphone device owned deemed incompatible with the Fitbit App
  • History of bariatric surgery or plans to obtain bariatric surgery during the study period
  • Current use of weight loss medications, or use of weight loss medications in the 6 months prior to initial pre-screening
  • Currently participating in a weight-loss program
  • Weight loss of greater than or equal to 10 lbs in the 6 months prior to initial pre-screening
  • Physical limitations that prevent walking at a brisk pace for at least 10 minutes without stopping
  • Use of a pacemaker or other implanted medical device
  • Currently pregnant
  • Currently breastfeeding
  • Less than 1-year post-partum
  • Plans to become pregnant within the study period
  • Lack of written confirmation that the potential participant has discussed study participation with their physician if they have been diagnosed with diabetes, hypertension, or has have a history of coronary heart disease
  • One or more study participants living in the household (enrollment limited to one participant per household)
  • Medical conditions that contraindicate weight loss or prevent completion of the study (e.g., current diagnosis of cancer or terminal illness, dementia, etc.)
  • +10 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Virginia

Charlottesville, Virginia, 22901, United States

RECRUITING

MeSH Terms

Conditions

ObesityOverweightWeight LossMotor Activity

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBody Weight ChangesBehavior

Study Officials

  • Becca Krukowski, Ph.D.

    University of Virginia

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Maddie Glover, B.S.

CONTACT

Teace Markwalter, M.P.H., CHES

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Model Details: Micro-randomized Factorial. One of two conditions.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

December 5, 2025

First Posted

December 18, 2025

Study Start

March 23, 2026

Primary Completion (Estimated)

May 1, 2027

Study Completion (Estimated)

June 1, 2027

Last Updated

March 31, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

Individual-level participant data will be de-identified and made available at the time of publication of peer-reviewed manuscript(s) based on the data. Study data will be shared via the Zenodo data repository at https://zenodo.org/. Analytic code will be made publicly available via Supplementary files for any publications and/or via Zenodo through a Zenodo-GitHub link. Study protocol, informed consent form, statistical analysis plan will also be available to be shared via clinicaltrials.gov.

Shared Documents
STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
Time Frame
De-identified, individual-level participant data will be made available at the time of publication of peer-reviewed manuscript(s) based on the data.
Access Criteria
Data will be made available via the Zenodo data repository (https://zenodo.org).
More information

Locations