NCT07221357

Brief Summary

The purpose of this study is to evaluate the safety and efficacy of pumitamig in combination with chemotherapy versus bevacizumab in combination with chemotherapy in participants with previously untreated, unresectable, or metastatic colorectal cancer

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
990

participants targeted

Target at P75+ for phase_2

Timeline
96mo left

Started Dec 2025

Longer than P75 for phase_2

Geographic Reach
25 countries

274 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress4%
Dec 2025Mar 2034

First Submitted

Initial submission to the registry

October 23, 2025

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 27, 2025

Completed
2 months until next milestone

Study Start

First participant enrolled

December 31, 2025

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 2, 2030

Expected
4.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 11, 2034

Last Updated

May 6, 2026

Status Verified

April 1, 2026

Enrollment Period

4.1 years

First QC Date

October 23, 2025

Last Update Submit

May 1, 2026

Conditions

Keywords

Metastatic Colorectal Cancer (mCRC)

Outcome Measures

Primary Outcomes (3)

  • Objective Response (OR) (confirmed complete response (CR) or partial response (PR)) by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 per investigator assessment

    Phase 2

    Up to 5 years

  • Progression Free Survival (PFS) by RECIST v1.1 per blinded independent central review (BICR)

    Phase 3

    Up to 5 years

  • Overall Survival (OS)

    Phase 3

    Up to 5 years

Secondary Outcomes (7)

  • PFS by RECIST v1.1 per investigator assessment

    Up to 5 years

  • Duration of Response (DOR) (CR or PR) by RECIST v1.1 per investigator assessment

    Up to 5 years

  • Time to Response (TTR) (CR or PR) by RECIST v1.1 per investigator assessment

    Up to 5 years

  • Disease control (Best Overall Response (BOR) of confirmed CR, confirmed PR, or Stable Disease (SD)) by RECIST v1.1 per investigator assessment

    Up to 5 years

  • Recommended dose of Pumitamig for Phase 3

    Up to 5 years

  • +2 more secondary outcomes

Study Arms (5)

Arm A1

EXPERIMENTAL
Drug: PumitamigDrug: FOLFOXDrug: FOLFIRI

Arm A2

EXPERIMENTAL
Drug: PumitamigDrug: FOLFOXDrug: FOLFIRI

Arm B

OTHER
Drug: FOLFOXDrug: FOLFIRIDrug: Bevacizumab

Arm C

EXPERIMENTAL
Drug: PumitamigDrug: FOLFOXDrug: FOLFIRIDrug: CAPOX

Arm D

OTHER
Drug: FOLFOXDrug: FOLFIRIDrug: BevacizumabDrug: CAPOX

Interventions

Specified dose on specified days

Also known as: BMS-986545, BNT327, PM8002
Arm A1Arm A2Arm C
FOLFOXDRUG

Specified dose on specified days

Arm A1Arm A2Arm BArm CArm D

Specified dose on specified days

Arm A1Arm A2Arm BArm CArm D

Specified dose on specified days

Arm BArm D
CAPOXDRUG

Specified dose on specified days

Arm CArm D

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participant must previously untreated, histologically confirmed recurrent or metastatic colorectal adenocarcinoma, not amenable to curative surgery.
  • Participant must have no known presence of mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) colorectal cancer (CRC) per historical results (a validated test should be used).
  • Participant must have no known presence of the gene that encodes the protein B-Raf (BRAF) V600E mutation per local testing.
  • Participant must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.

You may not qualify if:

  • Participant must not have any untreated known central nervous system (CNS) metastases including brain, leptomeningeal and/or spinal cord compression.
  • Participant must not have any prior malignancy active within the previous 2 years, except for locally curable cancers that have been apparently cured and considered to be of low risk of recurrence.
  • Participant must not have significant cardiovascular disease, such as myocardial infarction, unstable angina, arterial thrombosis or cerebrovascular accident within 6 months prior to randomization, uncontrolled hypertension (≥ 160 systolic, and/or ≥ 100 diastolic mm Hg) despite optimal medical management, or congenital long QT syndrome.
  • Participant must not have prior systemic treatment with an anti-PD-1, anti-programmed death (ligand)-1 (PD-L1), anti-PD-L2, CD137 agonists, or anti-cytotoxic T-lymphocyte associated protein 4 (CTLA-4) antibody, or any other antibody or drug specifically targeting T cell co-stimulation or checkpoint pathways or chemotherapy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (279)

Local Institution - 0428

Tucson, Arizona, 85724, United States

NOT YET RECRUITING

Local Institution - 0432

Springdale, Arkansas, 72762, United States

NOT YET RECRUITING

Local Institution - 0447

La Jolla, California, 92037, United States

NOT YET RECRUITING

USC/Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

RECRUITING

University of California, Irvine (UCI) Health - UC Irvine Medical Center

Orange, California, 92868, United States

RECRUITING

Local Institution - 0317

San Francisco, California, 94115, United States

NOT YET RECRUITING

Local Institution - 0330

Santa Monica, California, 90404, United States

NOT YET RECRUITING

Local Institution - 0293

Stanford, California, 94305, United States

NOT YET RECRUITING

Florida Cancer Specialists - East

Cape Coral, Florida, 33990, United States

RECRUITING

Florida Cancer Specialists - North

St. Petersburg, Florida, 33705, United States

RECRUITING

Moffitt Cancer Center

Tampa, Florida, 33612, United States

RECRUITING

Local Institution - 0276

Atlanta, Georgia, 30342, United States

NOT YET RECRUITING

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital

Marietta, Georgia, 30060, United States

RECRUITING

Local Institution - 0030

Chicago, Illinois, 60611, United States

NOT YET RECRUITING

Local Institution - 0433

Chicago, Illinois, 60637, United States

NOT YET RECRUITING

Local Institution - 0638

Fort Wayne, Indiana, 46805, United States

NOT YET RECRUITING

Local Institution - 0335

Iowa City, Iowa, 52242, United States

NOT YET RECRUITING

Local Institution - 0262

Baltimore, Maryland, 21287, United States

NOT YET RECRUITING

Maryland Oncology Hematology - Silver Spring

Silver Spring, Maryland, 20904, United States

RECRUITING

Local Institution - 0471

Boston, Massachusetts, 02114, United States

WITHDRAWN

Local Institution - 0430

Ann Arbor, Michigan, 48109, United States

NOT YET RECRUITING

Local Institution - 0254

Grand Rapids, Michigan, 49546, United States

NOT YET RECRUITING

Minnesota Oncology

Maple Grove, Minnesota, 55369, United States

RECRUITING

Local Institution - 0318

Kansas City, Missouri, 64111, United States

NOT YET RECRUITING

Washington University School OF Medicine-Siteman Cancer Center

St Louis, Missouri, 63110, United States

RECRUITING

Local Institution - 0334

Omaha, Nebraska, 68198, United States

NOT YET RECRUITING

Northwell Health/ RJ Zuckerberg Cancer Center

Lake Success, New York, 11042, United States

RECRUITING

Local Institution - 0270

Mineola, New York, 11501, United States

NOT YET RECRUITING

Local Institution - 0273

New Hyde Park, New York, 11042, United States

NOT YET RECRUITING

Local Institution - 0290

Charlotte, North Carolina, 28207, United States

NOT YET RECRUITING

Local Institution - 0526

Fargo, North Dakota, 58102, United States

NOT YET RECRUITING

Local Institution - 0339

Columbus, Ohio, 43210, United States

NOT YET RECRUITING

Local Institution - 0605

Oklahoma City, Oklahoma, 73104, United States

NOT YET RECRUITING

Lehigh Valley Health Network

Allentown, Pennsylvania, 18103, United States

RECRUITING

Local Institution - 0604

Pittsburgh, Pennsylvania, 15232, United States

NOT YET RECRUITING

Sanford Cancer Center

Sioux Falls, South Dakota, 57104, United States

RECRUITING

Local Institution - 0333

Nashville, Tennessee, 37203, United States

NOT YET RECRUITING

SCRI Oncology Partners

Nashville, Tennessee, 37203, United States

RECRUITING

Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North

Arlington, Texas, 76012, United States

RECRUITING

Texas Oncology, PA

Austin, Texas, 78705, United States

RECRUITING

Local Institution - 0252

Houston, Texas, 77030, United States

NOT YET RECRUITING

Texas Oncology - San Antonio

San Antonio, Texas, 78240, United States

RECRUITING

Local Institution - 0426

Salt Lake City, Utah, 84102, United States

NOT YET RECRUITING

Local Institution - 0278

Fairfax, Virginia, 22031, United States

NOT YET RECRUITING

Virginia Oncology Associates

Norfolk, Virginia, 23502, United States

RECRUITING

Local Institution - 0491

Edmonds, Washington, 98026-8032, United States

NOT YET RECRUITING

Local Institution - 0253

Seattle, Washington, 98109, United States

NOT YET RECRUITING

Local Institution - 0629

Spokane, Washington, 99218, United States

NOT YET RECRUITING

Northwest Cancer Specialists, P.C.

Vancouver, Washington, 98684, United States

RECRUITING

Hospital Británico de Buenos Aires

CABA, Buenos Aires, CP1280AEB, Argentina

RECRUITING

Instituto Alexander Fleming

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

RECRUITING

Local Institution - 0071

ABB, Buenos Aires F.D., C1199ABB, Argentina

NOT YET RECRUITING

Local Institution - 0632

San Miguel de Tucumán, Tucumán Province, T4000IHE, Argentina

NOT YET RECRUITING

Local Institution - 0174

Buenos Aires, 1039, Argentina

NOT YET RECRUITING

Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)

Buenos Aires, C1431FWO, Argentina

RECRUITING

Local Institution - 0630

Córdoba, X5000JHQ, Argentina

NOT YET RECRUITING

Local Institution - 0643

Camperdown, New South Wales, 2050, Australia

NOT YET RECRUITING

Local Institution - 0277

Liverpool, New South Wales, 2170, Australia

NOT YET RECRUITING

GenesisCare St Leonards

St Leonards, New South Wales, 2065, Australia

RECRUITING

Sunshine Coast University Hospital

Birtinya, Queensland, 4575, Australia

RECRUITING

Royal Brisbane and Women's Hospital

Brisbane, Queensland, 4029, Australia

RECRUITING

Local Institution - 0191

Woolloongabba, Queensland, 4102, Australia

NOT YET RECRUITING

Local Institution - 0156

Adelaide, South Australia, 5042, Australia

NOT YET RECRUITING

Lyell McEwin Hospital

Elizabeth Vale, South Australia, 5112, Australia

RECRUITING

Grampians Health

Ballarat Central, Victoria, 3350, Australia

RECRUITING

Local Institution - 0190

Epping, Victoria, 3076, Australia

NOT YET RECRUITING

Goulburn Valley Health

Shepparton, Victoria, 3630, Australia

RECRUITING

Local Institution - 0519

St Albans, Victoria, 3021, Australia

NOT YET RECRUITING

St. John of God Murdoch Hospital

Murdoch, Western Australia, 6150, Australia

RECRUITING

Local Institution - 0160

Malvern, 3144, Australia

NOT YET RECRUITING

Local Institution - 0159

Wentworthville, NSW2145, Australia

NOT YET RECRUITING

Local Institution - 0164

Feldkirch, 6800, Austria

NOT YET RECRUITING

Krankenhaus Der Barmherzigen Schwestern Linz

Linz, 4010, Austria

RECRUITING

Universitaetsklinik Salzburg

Salzburg, 5020, Austria

RECRUITING

Local Institution - 0176

Sankt Pölten, 3100, Austria

NOT YET RECRUITING

Local Institution - 0082

Vienna, A-1090, Austria

NOT YET RECRUITING

Local Institution - 0622

Bonheiden, Antwerpen, 2820, Belgium

NOT YET RECRUITING

Local Institution - 0103

Edegem, Antwerpen, 2650, Belgium

NOT YET RECRUITING

Cliniques universitaires Saint-Luc

Brussels, Bruxelles-Capitale, Région de, 1200, Belgium

RECRUITING

Local Institution - 0620

Charleroi, Hainaut, 6060, Belgium

WITHDRAWN

UZ Leuven

Leuven, Vlaams-Brabant, 3000, Belgium

RECRUITING

AZ Delta vzw

Roeselare, West-Vlaanderen, 8800, Belgium

RECRUITING

Local Institution - 0118

Brussels, 1000, Belgium

NOT YET RECRUITING

Local Institution - 0267

Curitiba, Paraná, 81480-580, Brazil

NOT YET RECRUITING

Local Institution - 0331

Natal/RN, Rio Grande do Norte, 59062-000, Brazil

NOT YET RECRUITING

Local Institution - 0375

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

NOT YET RECRUITING

Local Institution - 0342

Porto Alegre, Rio Grande do Sul, 91610-000, Brazil

NOT YET RECRUITING

Local Institution - 0373

Santa Cruz do Sul, Rio Grande do Sul, 96810-110, Brazil

NOT YET RECRUITING

Local Institution - 0444

Chapecó, Santa Catarina, 89812-211, Brazil

NOT YET RECRUITING

Local Institution - 0266

Barretos, São Paulo, 14784400, Brazil

NOT YET RECRUITING

Local Institution - 0264

São José do Rio Preto, 15090-000, Brazil

NOT YET RECRUITING

Local Institution - 0268

São Paulo, 01246-000, Brazil

NOT YET RECRUITING

Local Institution - 0341

São Paulo, 01308-060, Brazil

NOT YET RECRUITING

Local Institution - 0550

Calgary, Alberta, T2N 5G2, Canada

NOT YET RECRUITING

Local Institution - 0260

Halifax, Nova Scotia, B3H 3A7, Canada

NOT YET RECRUITING

Local Institution - 0255

Ottawa, Ontario, K1H 8L6, Canada

NOT YET RECRUITING

Local Institution - 0424

Toronto, Ontario, M4N 3M5, Canada

NOT YET RECRUITING

Local Institution - 0421

Toronto, Ontario, M5G 2M9, Canada

NOT YET RECRUITING

Centre Hospitalier de l'Université de Montréal

Montreal, Quebec, H2X 3E4, Canada

RECRUITING

Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada

RECRUITING

Local Institution - 0261

Sherbrooke, Quebec, J1H 5N4, Canada

NOT YET RECRUITING

Local Institution - 0171

Recoleta, Santiago Metropolitan, 8420391, Chile

NOT YET RECRUITING

Local Institution - 0463

Santiago, Santiago Metropolitan, 7500921, Chile

NOT YET RECRUITING

Local Institution - 0175

Santiago, Santiago Metropolitan, 7620002, Chile

NOT YET RECRUITING

Local Institution - 0595

Hefei, Anhui, 230601, China

NOT YET RECRUITING

Local Institution - 0499

Chongqing, Chongqing Municipality, 400030, China

NOT YET RECRUITING

Local Institution - 0354

Fuzhou, Fujian, 350014, China

NOT YET RECRUITING

Local Institution - 0388

Fuzhou Fujian, Fujian, 350001, China

NOT YET RECRUITING

Local Institution - 0414

Guangzhou, Guangdong, 510000, China

NOT YET RECRUITING

Local Institution - 0130

Guangzhou, Guangdong, 510555, China

NOT YET RECRUITING

Local Institution - 0390

Tianjin, Hebei, 300060, China

NOT YET RECRUITING

Local Institution - 0353

Harbin, Heilongjiang, 150081, China

NOT YET RECRUITING

Local Institution - 0384

Nanyang, Henan, 473009, China

NOT YET RECRUITING

Local Institution - 0391

Wuhan, Hubei, 430079, China

NOT YET RECRUITING

Local Institution - 0376

Changsha, Hunan, 410013, China

NOT YET RECRUITING

Local Institution - 0411

Changsha, Hunan, 410031, China

NOT YET RECRUITING

Local Institution - 0398

Yangzhou, Jiangsu, 225001, China

NOT YET RECRUITING

Local Institution - 0381

Nanchang, Jiangxi, 330006, China

NOT YET RECRUITING

Local Institution - 0352

Shenyang, Liaoning, 110001, China

NOT YET RECRUITING

Local Institution - 0355

Shenyang, Liaoning, 110042, China

NOT YET RECRUITING

Local Institution - 0382

Jinan, Shandong, 250117, China

NOT YET RECRUITING

Local Institution - 0378

Shanghai, Shanghai Municipality, 200120, China

NOT YET RECRUITING

Local Institution - 0498

Chengdu, Sichuan, 610041, China

NOT YET RECRUITING

Local Institution - 0360

Hangzhou, Zhejiang, 310003, China

NOT YET RECRUITING

Local Institution - 0383

Hangzhou, Zhejiang, 310022, China

NOT YET RECRUITING

Local Institution - 0409

Beijing, 100034, China

NOT YET RECRUITING

Local Institution - 0457

Hangzhou, 310009, China

NOT YET RECRUITING

Local Institution - 0416

Nanjing, Jiangsu, 210009, China

NOT YET RECRUITING

Local Institution - 0356

Shanghai, 200032, China

NOT YET RECRUITING

Local Institution - 0412

Wuhan, 430022, China

NOT YET RECRUITING

Local Institution - 0489

Prague, Praha 10, 10034, Czechia

NOT YET RECRUITING

Local Institution - 0248

Prague, Praha 5, 150 06, Czechia

NOT YET RECRUITING

Local Institution - 0461

Prague, Praha, Hlavní Mesto, 12808, Czechia

NOT YET RECRUITING

Local Institution - 0180

Brno, 656 53, Czechia

NOT YET RECRUITING

Local Institution - 0188

Hradec Králové, 500 05, Czechia

NOT YET RECRUITING

Local Institution - 0467

Olomouc, 77520, Czechia

NOT YET RECRUITING

CHU Bordeaux Haut-Leveque

Pessac, Aquitaine, 33600, France

RECRUITING

Local Institution - 0590

Besançon, Doubs, 25000, France

NOT YET RECRUITING

CHU Rangueil

Toulouse, Haute-Garonne, 31059, France

RECRUITING

CHU Charles Nicolle

Rouen, Haute-Normandie, 76031, France

RECRUITING

Local Institution - 0182

Saint-Herblain, Loire-Atlantique, 44805, France

NOT YET RECRUITING

Local Institution - 0618

Lorient, Morbihan, 56100, France

NOT YET RECRUITING

Local Institution - 0613

Lille, Nord, 59020, France

NOT YET RECRUITING

Local Institution - 0125

Nantes, Pays de la Loire Region, 44093, France

NOT YET RECRUITING

Local Institution - 0121

Marseille, Provence-Alpes-Côte d'Azur Region, 13273, France

NOT YET RECRUITING

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand

Dijon, 21000, France

RECRUITING

Local Institution - 0616

Limoges, 87042, France

NOT YET RECRUITING

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

Marseille, 13385, France

RECRUITING

Hôpital Saint Antoine

Paris, 75571, France

RECRUITING

Local Institution - 0634

Suresnes, 92151, France

NOT YET RECRUITING

Local Institution - 0098

Villejuif, 94805, France

NOT YET RECRUITING

Local Institution - 0591

Erlangen, Bavaria, 91054, Germany

NOT YET RECRUITING

Local Institution - 0607

Hanover, Lower Saxony, 30161, Germany

NOT YET RECRUITING

Universitaetsklinikum Carl Gustav Carus Dresden

Dresden, Saxony, 01307, Germany

RECRUITING

Local Institution - 0035

Berlin, 10117, Germany

NOT YET RECRUITING

Local Institution - 0061

Bochum, 44791, Germany

NOT YET RECRUITING

Local Institution - 0588

Chemnitz, 09113, Germany

NOT YET RECRUITING

Marien Hospital Düsseldorf

Düsseldorf, 40479, Germany

RECRUITING

Krankenhaus Nordwest GmbH

Frankfurt, 60488, Germany

RECRUITING

Universitaetsmedizin Goettingen

Göttingen, 37075, Germany

RECRUITING

Facharztzentrum Eppendorf

Hamburg, 20249, Germany

RECRUITING

Local Institution - 0594

Hamburg, 22763, Germany

NOT YET RECRUITING

Universitatsklinikum Leipzig

Leipzig, D-04103, Germany

RECRUITING

Local Institution - 0060

Mainz, 55131, Germany

NOT YET RECRUITING

Local Institution - 0059

Mannheim, 68167, Germany

NOT YET RECRUITING

Klinikum Neuperlach

München, 81737, Germany

RECRUITING

Local Institution - 0037

Ulm, 89081, Germany

NOT YET RECRUITING

Local Institution - 0203

Veszprém, 8200, Hungary

NOT YET RECRUITING

Local Institution - 0010

Nashik, Dādra and Nagar Haveli and Damān and Diu, 422001, India

NOT YET RECRUITING

Local Institution - 0036

Mumbai, Maharashtra, 400012, India

NOT YET RECRUITING

Local Institution - 0552

Mumbai, Maharashtra, 400036, India

WITHDRAWN

Local Institution - 0006

Delhi, 110029, India

NOT YET RECRUITING

Local Institution - 0554

Delhi, 110029, India

NOT YET RECRUITING

Local Institution - 0557

Puducherry, 605006, India

WITHDRAWN

Local Institution - 0038

Pune, 411001, India

NOT YET RECRUITING

Local Institution - 0617

Castellana Grotte, Bari, 70013, Italy

NOT YET RECRUITING

IRCCS Casa Sollievo della Sofferenza

San Giovanni Rotondo, Foggia, 71013, Italy

RECRUITING

Local Institution - 0619

Tricase, Lecce, 73039, Italy

NOT YET RECRUITING

ASST Grande Ospedale Metropolitano Niguarda

Milan, Milano, 20162, Italy

RECRUITING

Local Institution - 0614

Aviano, Pordenone, 33081, Italy

NOT YET RECRUITING

Azienda Ospedaliero Universitaria Pisana

Pisa, Tuscany, 56126, Italy

RECRUITING

Istituto Oncologico Veneto IRCCS

Padova, Veneto, 35128, Italy

RECRUITING

Local Institution - 0609

Avellino, 83100, Italy

NOT YET RECRUITING

Local Institution - 0610

Bari, 70124, Italy

NOT YET RECRUITING

Local Institution - 0227

Catania, 95124, Italy

NOT YET RECRUITING

Local Institution - 0615

La Spezia, 19124, Italy

NOT YET RECRUITING

Local Institution - 0111

Milan, 20133, Italy

NOT YET RECRUITING

Ospedale San Raffaele

Milan, 20132, Italy

RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale

Naples, 80131, Italy

RECRUITING

Local Institution - 0612

Ravenna, 48121, Italy

NOT YET RECRUITING

Local Institution - 0233

Reggio Emilia, 42123, Italy

NOT YET RECRUITING

Local Institution - 0641

Toyoake, Aichi-ken, 470-1192, Japan

NOT YET RECRUITING

Local Institution - 0053

Chiba, Chiba, 260-8717, Japan

NOT YET RECRUITING

National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan

RECRUITING

Local Institution - 0045

Matsuyama, Ehime, 791-0280, Japan

NOT YET RECRUITING

Hokkaido University Hospital

Sapporo, Hokkaido, 0608648, Japan

RECRUITING

Local Institution - 0047

Kobe, Hyōgo, 6500047, Japan

NOT YET RECRUITING

Local Institution - 0056

Yokohama, Kanagawa, 2418515, Japan

NOT YET RECRUITING

Local Institution - 0476

Kurashiki, Okayama-ken, 710-8602, Japan

NOT YET RECRUITING

The University of Osaka Hospital

Suita, Osaka, 565-0871, Japan

RECRUITING

Local Institution - 0521

Takatsuki, Osaka, 569-8686, Japan

NOT YET RECRUITING

Local Institution - 0046

Hidaka, Saitama, 350-1298, Japan

NOT YET RECRUITING

National Cancer Center Hospital

Chuo-ku, Tokyo, 104-0045, Japan

RECRUITING

The Cancer Institute Hospital of JFCR

Koto-ku, Tokyo, 135-8550, Japan

RECRUITING

Local Institution - 0642

Yamagata, Yamagata, 990-9585, Japan

NOT YET RECRUITING

Local Institution - 0473

Chikusa-ku, 464-8681, Japan

NOT YET RECRUITING

National Hospital Organization Kyushu Cancer Center

Fukuoka, 811-1395, Japan

RECRUITING

Local Institution - 0597

Kitaadachi-gun, 362-0806, Japan

NOT YET RECRUITING

Local Institution - 0506

Osaka, 541-8567, Japan

NOT YET RECRUITING

Local Institution - 0067

Sendai, 980-8574, Japan

NOT YET RECRUITING

Local Institution - 0054

Sunto-gun, 411-8777, Japan

NOT YET RECRUITING

Local Institution - 0173

Eindhoven, North Brabant, 5623 EJ, Netherlands

NOT YET RECRUITING

Local Institution - 0112

Amsterdam, North Holland, 1105 AZ, Netherlands

NOT YET RECRUITING

Local Institution - 0170

Groningen, 9713 GZ, Netherlands

NOT YET RECRUITING

Local Institution - 0216

Tilburg, 5022 GC, Netherlands

NOT YET RECRUITING

Local Institution - 0167

Utrecht, 3543 AZ, Netherlands

NOT YET RECRUITING

Local Institution - 0364

Krakow, Lesser Poland Voivodeship, 31-826, Poland

NOT YET RECRUITING

Local Institution - 0452

Jelenia Góra, Lower Silesian Voivodeship, 58-506, Poland

NOT YET RECRUITING

Luxmed Onkologia sp. z o. o.

Warsaw, Masovian Voivodeship, 01-748, Poland

RECRUITING

Local Institution - 0525

Warsaw, Masovian Voivodeship, 02-507, Poland

NOT YET RECRUITING

Local Institution - 0359

Warsaw, Masovian Voivodeship, 03-411, Poland

NOT YET RECRUITING

Local Institution - 0365

Brzozów, Podkarpackie Voivodeship, 36-200, Poland

NOT YET RECRUITING

Local Institution - 0626

Gdansk, Pomeranian Voivodeship, 80-219, Poland

NOT YET RECRUITING

Local Institution - 0451

Gliwice, Silesian Voivodeship, 44-101, Poland

NOT YET RECRUITING

Local Institution - 0361

Koszalin, West Pomeranian Voivodeship, 75-581, Poland

NOT YET RECRUITING

Local Institution - 0362

Opole, 45-372, Poland

NOT YET RECRUITING

Fundeni Clinical Institute

Bucharest, Bucharest, 022328, Romania

RECRUITING

Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor

Cluj-Napoca, Cluj, 400162, Romania

RECRUITING

Centrul de Oncologie "Sfântul Nectarie"

Craiova, Dolj, 200542, Romania

RECRUITING

Institutul Oncologic Cluj

Cluj-Napoca, 400015, Romania

RECRUITING

Local Institution - 0139

Floresti/ Cluj, 407280, Romania

NOT YET RECRUITING

S.C. Centrul de Oncologie Euroclinic S.R.L.

Iași, 700106, Romania

RECRUITING

Institutul Regional de Oncologie

Iași, 700483, Romania

RECRUITING

National Cancer Centre Singapore

Singapore, Central Singapore, 168583, Singapore

RECRUITING

Local Institution - 0147

Singapore, 119074, Singapore

NOT YET RECRUITING

Local Institution - 0285

Singapore, 308442, Singapore

NOT YET RECRUITING

Local Institution - 0511

Singapore, 329563, Singapore

NOT YET RECRUITING

Seoul National University Bundang Hospital

Seongnam, Gyeonggido, 13620, South Korea

RECRUITING

Seoul National University Hospital

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea

RECRUITING

Asan Medical Center

Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea

RECRUITING

Samsung Medical Center

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

RECRUITING

The Catholic Univ. of Korea Seoul St. Mary's Hospital

Seoul, Seoul-teukbyeolsi [Seoul], 06591, South Korea

RECRUITING

Local Institution - 0405

Seoul, 120-752, South Korea

NOT YET RECRUITING

Local Institution - 0163

Badalona, Barcelona [Barcelona], 08916, Spain

NOT YET RECRUITING

Local Institution - 0240

Barcelona, Barcelona [Barcelona], 08035, Spain

NOT YET RECRUITING

Local Institution - 0624

Madrid, Madrid, Comunidad de, 28034, Spain

NOT YET RECRUITING

Local Institution - 0229

Madrid, Madrid, Comunidad de, 28041, Spain

NOT YET RECRUITING

Complejo Hospitalario de Navarra

Pamplona, Navarre, 31009, Spain

RECRUITING

Local Institution - 0472

Elche (alicante), 03203, Spain

NOT YET RECRUITING

Hospital General Universitario Gregorio Marañon

Madrid, 28007, Spain

RECRUITING

H.R.U Málaga - Hospital General

Málaga, 29011, Spain

RECRUITING

Local Institution - 0625

Salamanca, 37007, Spain

NOT YET RECRUITING

Local Institution - 0593

Santiago de Compostela, 15706, Spain

NOT YET RECRUITING

Hospital Universitario Virgen Del Rocio

Seville, 41013, Spain

RECRUITING

Local Institution - 0074

Stockholm, Stockholm County, 17176, Sweden

NOT YET RECRUITING

Local Institution - 0185

Gothenburg, Västra Götaland County, 41685, Sweden

NOT YET RECRUITING

Local Institution - 0400

Lund, 22184, Sweden

NOT YET RECRUITING

Local Institution - 0301

Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan

NOT YET RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan

RECRUITING

National Cheng Kung University Hospital

Tainan, 704, Taiwan

RECRUITING

National Taiwan University Hospital

Taipei, 10002, Taiwan

RECRUITING

Local Institution - 0300

Taipei, 11217, Taiwan

NOT YET RECRUITING

Chang Gung Medical Foundation-Linkou Branch

Taoyuan, 333, Taiwan

RECRUITING

Local Institution - 0020

Adana, 1370, Turkey (Türkiye)

NOT YET RECRUITING

Local Institution - 0065

Ankara, 06100, Turkey (Türkiye)

NOT YET RECRUITING

Local Institution - 0018

Erzurum, 25070, Turkey (Türkiye)

NOT YET RECRUITING

Local Institution - 0296

Istanbul, 34214, Turkey (Türkiye)

NOT YET RECRUITING

Local Institution - 0295

Kadiköy/Istanbul, 41380, Turkey (Türkiye)

NOT YET RECRUITING

The Christie NHS Foundation Trust

Manchester, Lancashire, M20 4BX, United Kingdom

RECRUITING

Local Institution - 0600

Enfield, London, EN28JL, United Kingdom

NOT YET RECRUITING

Local Institution - 0366

Oxford, Oxfordshire, OX3 7LJ, United Kingdom

NOT YET RECRUITING

Local Institution - 0540

Birmingham, West Midlands, B15 2TT, United Kingdom

NOT YET RECRUITING

Local Institution - 0601

Cardiff, CF14 2TL, United Kingdom

NOT YET RECRUITING

Local Institution - 0602

Dorchester, DT1 2JY, United Kingdom

NOT YET RECRUITING

Local Institution - 0307

Glasgow, G12 0YN, United Kingdom

NOT YET RECRUITING

Royal Marsden Hospital Sutton

London, SM2 5PT, United Kingdom

RECRUITING

Royal Marsden Hospital

London, SW3 6JJ, United Kingdom

RECRUITING

Maidstone and Tunbridge Wells NHS Trust

Maidstone, ME16 9QQ, United Kingdom

RECRUITING

Local Institution - 0310

Newcastle upon Tyne, NE7 7DN, United Kingdom

NOT YET RECRUITING

Related Links

MeSH Terms

Conditions

Colorectal Neoplasms

Interventions

Folfox protocolIFL protocolBevacizumab

Condition Hierarchy (Ancestors)

Intestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal Diseases

Intervention Hierarchy (Ancestors)

Antibodies, Monoclonal, HumanizedAntibodies, MonoclonalAntibodiesImmunoglobulinsImmunoproteinsBlood ProteinsProteinsAmino Acids, Peptides, and ProteinsSerum GlobulinsGlobulins

Study Officials

  • Bristol-Myers Squibb

    Bristol-Myers Squibb

    STUDY DIRECTOR

Central Study Contacts

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

CONTACT

First line of the email MUST contain NCT # and Site #.

CONTACT

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 23, 2025

First Posted

October 27, 2025

Study Start

December 31, 2025

Primary Completion (Estimated)

February 2, 2030

Study Completion (Estimated)

March 11, 2034

Last Updated

May 6, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
See Plan Description
Access Criteria
See Plan Description
More information

Locations