A Study Of Resilience And Mental Well-Being Through Breathing Practice For Clinical Care Professionals

NCT07218458 | Recruiting

• 1 other identifier: 25-009320
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 4

Brief Summary

The purpose of this study is to assess the immediate and long-term effects of structured breathing on clinical symptoms related to mental health including anxiety, depression, perceived stress, and sleep quality.

Conditions

Burnout, Healthcare Workers; Breathing Exercises

Keywords

burnout; breathing

Outcome Measures

Primary Outcomes (7)

• Assess feasibility of the structured breathing-based intervention among healthcare professionals via ease of recruitment

  This outcome measure will assess whether the structured breathing-based intervention is feasible among healthcare professionals via ease of recruitment reported by study staff.

  Enrollment to end of study participation at 4 months.

• Assess feasibility of the structured breathing-based intervention among healthcare professionals via retention statistics

  This outcome measure will assess the feasibility of the structured breathing-based intervention among healthcare professionals by examining retention rates throughout study duration.

  Enrollment to end of study participation at 4 months

• Assess feasibility of the structured breathing-based intervention among healthcare professionals via mobile app engagement metrics

  This outcome measure will assess whether the structured breathing-based intervention is feasible among healthcare professionals by analyzing app usage metrics from participants.

  Enrollment to end of study participation at 4 months

• Assess feasibility of structured breathing-based intervention among healthcare professionals via Feasibility of Intervention Measure

  To assess the feasibility of a structured breathing intervention among healthcare professionals using Feasibility of Intervention Measure (FIM). Feasibility of Intervention Measure is a four-item measure of implementation feasibility with scores ranging from 1-5, with higher scores indicating greater feasibility.

  Enrollment to end of study participation at 4 months

• Assess appropriateness of structured breathing-based intervention among healthcare professionals

  To assess the appropriateness of a structured breathing intervention among healthcare professionals using Intervention Appropriateness Measure (IAM). Intervention Appropriateness Measure is a four-item measure with a scale of responses from 1-5, with higher scores indicating greater appropriateness.

  Enrollment to end of study participation at 4 months

• Assess acceptability of structured breathing-based intervention among healthcare professionals

  To assess the acceptability of a structured breathing intervention among healthcare professionals utilizing the Acceptability of Intervention Measure (AIM). Acceptability of Intervention Measure is a four-item measure with responses from 1-5, with higher scores equating to greater acceptability.

  From enrollment to the end of study participation at 4 months

• Assess participant satisfaction related to breathing-based intervention

  Participant satisfaction will be assessed through a mixed-methods approach combining quantitative surveys (exit survey) and qualitative participant interviews (4 month in-person visit/interview).

  Enrollment to end of study participation at 4 months.

Secondary Outcomes (1)

• Evaluate intervention adherence, usability, and engagement metrics via mobile application

  Enrollment to end of treatment at 4 months.

Other Outcomes (4)

• Assess the physiological effects of the breathing-based intervention

  Enrollment to end of intervention at 4 months. Additional assessments during data analysis period.

• Assess the psychological effects of the breathing-based intervention

  Enrollment to end of intervention at 4 months. Additional assessments during data analysis period

• Assess feasibility of collecting physiological and psychological data

  Enrollment to end of study participation at 4 months.

Study Arms (1)

Breathing Intervention

EXPERIMENTAL

Engaging in self-guided breathing sessions to improve brain circulation and mental well-being.

Behavioral: Structured Breathing

Interventions

Structured Breathing BEHAVIORAL

15, 30, or 36 minute structured breathing sessions based on personal skill level.

Breathing Intervention

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants must be healthcare professionals at the above-mentioned 4 MCHS sites (Eau Claire, La Crosse, Mankato, Albert Lea).
• Must score ≥40 on Copenhagen Burnout Inventory Q1-6.
• Participants must be physically fit enough to perform light exercise.
• Participants should read and understand English well enough to consent, complete measures, and follow instructions.
• Participants must have access to a smartphone or tablet.

You may not qualify if:

• Active primary psychotic disorder or substance use disorder (except nicotine dependence) within the past year.
• Severe or unstable medical condition that could interfere with participation or data collection.
• Active neurological condition (including seizure disorder, traumatic brain injury, or stroke) that could affect cognitive functioning or brain imaging results.
• Chronic lung disease (e.g., COPD, cystic fibrosis) or aneurysm.
• Current pregnancy or planning to become pregnant during the study period

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (4)

Mayo Clinic Health System-Albert Lea

Albert Lea, Minnesota, 56007, United States

ACTIVE NOT RECRUITING

Mayo Clinic Health System-Mankato

Mankato, Minnesota, 56001, United States

ACTIVE NOT RECRUITING

Mayo Clinic Health System-Eau Claire Clinic

Eau Claire, Wisconsin, 54703, United States

RECRUITING

Mayo Clinic Health System-La Crosse

La Crosse, Wisconsin, 54601, United States

ACTIVE NOT RECRUITING

Related Publications (1)

• Sharma P, Osman R, Nycklemoe M, Boos DM, Murphy CM, Flock C, Jacobson DN, Lim S, Nation JL, Wilson MA, Schuldt K, Min PH. Evaluation of a structured breathing-based intervention to reduce burnout and enhance mental well-being among healthcare professionals in community-based practice settings: study protocol for a single-arm pilot feasibility trial. BMJ Open. 2026 Feb 27;16(2):e113105. doi: 10.1136/bmjopen-2025-113105.

  PMID: 41760153 DERIVED

Related Links

• Mayo Clinic Clinical Trials

MeSH Terms

Conditions

Burnout, Psychological; Respiratory Aspiration

Condition Hierarchy (Ancestors)

Stress, Psychological; Behavioral Symptoms; Behavior; Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Pravesh Sharma, MD

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Danielle Boos

CONTACT

715-464-8173; boos.danielle@mayo.edu

Paul Min, PhD

CONTACT

507-255-2814; min.paul@mayo.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 15, 2025
• First Posted: October 20, 2025
• Study Start: October 27, 2025
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: May 5, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (4)