NCT07217535

Brief Summary

The goal of this observational study is to learn more about how genes impact the risk of kidney disease. Anyone 18 or older living in the US is eligible, and a diagnosis of kidney disease is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50,000

participants targeted

Target at P75+ for all trials

Timeline
31mo left

Started Apr 2026

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress2%
Apr 2026Oct 2028

First Submitted

Initial submission to the registry

October 14, 2025

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 16, 2025

Completed
6 months until next milestone

Study Start

First participant enrolled

April 23, 2026

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 31, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2028

Last Updated

April 24, 2026

Status Verified

April 1, 2026

Enrollment Period

2.5 years

First QC Date

October 14, 2025

Last Update Submit

April 23, 2026

Conditions

Kidney Disease, End-StageKidney DiseasesKidney Diseases, ChronicKidney Diseases,CysticKidney DiseaseKidney Disease, Chronic

Outcome Measures

Primary Outcomes (1)

  • Genetic risk variants associated with kidney disease

    Genetic factors will be measured through whole exome sequencing along with genotyping of common variants, and then correlated with kidney disease and/or kidney disease subtype.

    2 years

Study Arms (2)

Kidney disease cases

Study participants who have been diagnosed with any form of kidney disease, either currently or in the past.

Genetic: Saliva sampleOther: Health surveys

Kidney disease controls

Study participants who have never been diagnosed with any form of kidney disease, either currently or in the past.

Genetic: Saliva sampleOther: Health surveys

Interventions

Saliva sampleGENETIC

Saliva sample is sent via prepaid US Mail for DNA extraction

Kidney disease casesKidney disease controls
Health surveysOTHER

Health surveys are filled out online in the study portal.

Kidney disease casesKidney disease controls

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population consists of anyone at least 18 years old who lives in the United States, including both individuals who have or had kidney disease and those who have not. Participants include males, females, non-binary, and all race-ethnic groups.

You may qualify if:

  • age 18 years or older
  • currently living in the United States
  • able to understand and follow written instructions in English
  • have access to the internet and a computer, laptop, tablet or smart phone
  • willing to provide written informed consent for participation
  • willing to provide DNA via a saliva sample using a collection kit mailed to the study participant's home
  • willing to complete a survey with questions about health related to the study of kidney disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Rutgers, The State University of New Jersey

Piscataway, New Jersey, 08854, United States

RECRUITING

Related Links

MeSH Terms

Conditions

Kidney DiseasesRenal Insufficiency, ChronicKidney Failure, ChronicKidney Diseases, Cystic

Interventions

Health Surveys

Condition Hierarchy (Ancestors)

Urologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesRenal InsufficiencyChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Surveys and QuestionnairesData CollectionEpidemiologic MethodsInvestigative TechniquesHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public Health

Study Officials

  • Tara Matise, Ph.D.

    Rutgers, The State University of New Jersey

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Tara Matise, Ph.D.

CONTACT

858-445-3125rugcc-kd@rutgers.edu

Steve Buyske, Ph.D.

CONTACT

848-445-7680rutgers-kd@rugcc.edu

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Distinguished Professor

Study Record Dates

First Submitted

October 14, 2025

First Posted

October 16, 2025

Study Start

April 23, 2026

Primary Completion (Estimated)

October 31, 2028

Study Completion (Estimated)

October 31, 2028

Last Updated

April 24, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations

US(1)