Rutgers University Study of the Genetics of Pulmonary Hypertension

NCT07217522 | Recruiting

• 1 other identifier: Pro2025001041
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn more about how genes impact the risk of pulmonary hypertension. Anyone 18 or older living in the US is eligible, and a diagnosis of PH is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.

Conditions

Pulmonary Hypertension; Pulmonary Arterial Hypertension; Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH); Pulmonary Arterial Hypertension Associated With Connective Tissue Disease; Pulmonary Arterial Hypertension Associated With Connective Tissue Disease (Disorder); Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder); Pulmonary Arterial Hypertension of Congenital Heart Disease; Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension

Outcome Measures

Primary Outcomes (1)

• Genetic risk variants associated with pulmonary hypertension

  Genetic factors will be measured through whole exome sequencing along with genotyping of common variants, and then correlated with pulmonary hypertension and pulmonary hypertension subtype.

  2 years

Study Arms (2)

Pulmonary hypertension cases

Study participants who have been diagnosed with any form of pulmonary hypertension, either currently or in the past.

Genetic: Saliva sample; Other: Health surveys

Pulmonary hypertension controls

Study participants who have not been diagnosed with any form of pulmonary hypertension, either currently or in the past.

Genetic: Saliva sample; Other: Health surveys

Interventions

Saliva sample GENETIC

Saliva sample is sent via prepaid US Mail for DNA extraction

Pulmonary hypertension cases; Pulmonary hypertension controls

Health surveys OTHER

Health surveys are filled out online in the study portal.

Pulmonary hypertension cases; Pulmonary hypertension controls

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of anyone at least 18 years old who lives in the United States, including both individuals who have or had pulmonary hypertension and those who have not. Participants include males, females, non-binary, and all race-ethnic groups.

You may qualify if:

• age 18 years or older
• currently living in the United States
• able to understand and follow written instructions in English
• have access to the internet and a computer, laptop, tablet or smart phone
• willing to provide written informed consent for participation
• willing to provide DNA via a saliva sample using a collection kit mailed to the study participant's home
• willing to complete a survey with questions about health related to the study of pulmonary hypertension.

You may not qualify if:

• Age 17 or below
• Not currently living in the United States
• Not able to participate in an online research study in English

Sponsors & Collaborators

• Rutgers, The State University of New Jersey: lead

Study Sites (1)

Rutgers University, Piscataway, New Jersey 08854

Piscataway, New Jersey, 08854, United States

RECRUITING

Related Links

• Informational website about the study

MeSH Terms

Conditions

Hypertension, Pulmonary; Pulmonary Arterial Hypertension

Interventions

Health Surveys

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Tara Matise, Ph.D.

  Rutgers, The State University of New Jersey

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tara Matise, Ph.D.

CONTACT

848-445-3125; rugcc-ph@rutgers.edu

Steve Buyske, Ph.D.

CONTACT

rugcc-ph@rutgers.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Distinguished Professor

Study Record Dates

• First Submitted: October 14, 2025
• First Posted: October 16, 2025
• Study Start: August 23, 2025
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: November 3, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)