Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 30/100

Failure Rate

11.4%

88 terminated/withdrawn out of 773 trials

Success Rate

82.5%

-4.0% vs industry average

Late-Stage Pipeline

33%

255 trials in Phase 3/4

Results Transparency

61%

255 of 416 completed trials have results

Key Signals

140 recruiting255 with results63 terminated25 withdrawn

Enrollment Performance

Analytics

Phase 1
206(30.4%)
Phase 2
206(30.4%)
Phase 3
181(26.7%)
Phase 4
74(10.9%)
N/A
8(1.2%)
Early Phase 1
3(0.4%)
678Total
Phase 1(206)
Phase 2(206)
Phase 3(181)
Phase 4(74)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (773)

Showing 20 of 773 trials
NCT07646548Phase 1Not Yet Recruiting

Pharmacokinetics and Tolerability of Subcutaneous Dupilumab Coformulated With Berahyaluronidase Alfa and Dupilumab Without Berahyaluronidase Alfa in Healthy Participants

Role: collaborator

NCT07058012Phase 2Recruiting

A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)

Role: collaborator

NCT07053423Phase 4Recruiting

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

Role: collaborator

NCT07214727Phase 1Recruiting

A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease

Role: collaborator

NCT05929664Phase 2Suspended

Cemiplimab Plus Fianlimab for the Treatment of Locally Advanced Head and Neck Basal Cell Carcinoma Before Surgery

Role: collaborator

NCT07637851Phase 1Not Yet Recruiting

Safety and Efficacy of Ubamatamab With First-line Chemotherapy in Ovarian Cancer

Role: collaborator

NCT06449313Phase 2Recruiting

Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node Involvement

Role: collaborator

NCT07477704Phase 2Recruiting

A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

Role: lead

NCT07393282Phase 3Recruiting

A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)

Role: lead

NCT04916002Phase 2Terminated

A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer

Role: lead

NCT06585410Phase 3Recruiting

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

Role: lead

NCT06975787Phase 1Recruiting

Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis

Role: lead

NCT07286214Phase 4Recruiting

Sarilumab Efficacy and Safety in Adults With Early Polymyalgia Rheumatica

Role: collaborator

NCT06790602Phase 2Recruiting

Cemiplimab Plus Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma

Role: collaborator

NCT07631637Phase 2Not Yet Recruiting

Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)

Role: lead

NCT07626411Phase 3Not Yet Recruiting

Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation

Role: lead

NCT06140524Phase 2Recruiting

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma

Role: lead

NCT06444880Phase 2Recruiting

Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies

Role: collaborator

NCT06393946Active Not Recruiting

Study in Adults With Severe Chronic Rhinosinusitis With Nasal Polyposis Treated With Dupilumab in France

Role: collaborator

NCT04287621Completed

Registry of Asthma Patients Initiating DUPIXENT®

Role: lead