Is the Two-minute Step Test an Alternative to the Six-minute Walk Test in Pulmonary Hypertension?

NCT07193173 | Active Not Recruiting

• 1 other identifier: 2460
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this observational study is to evaluate the validity of the 2-minute step test in assessing functional capacity in pulmonary hypertension.

Conditions

Pulmonary Hypertension

Keywords

Pulmonary Hypertension; 2 minute step test; 6 minute walk test; validation

Outcome Measures

Primary Outcomes (1)

• 2 Minute Step Test

  The 2-minute step test (2MST) is a test used to assess functional capacity. The maximum number of knee lifts the individual can perform within 2 minutes will be counted, with the minimum height occurring at the midpoint between the patella and the anterior superior iliac spine (during steady walking, without changing position). The test will be performed with a mobile ergospirometer (K5, Cosmed, Italy). Oxygen consumption, task-based heart rate, and ventilation obtained during the 2MST will be recorded. In addition, the Borg dyspnea and fatigue scale will also be included in the assessment.

  2 minutes

Secondary Outcomes (2)

• Functional capacity

  6 minutes

• mMRC Dyspnea Scale

  5 minutes

Interventions

2 minute step test OTHER

The 2-Minute Step Test (2MST) is a simple, validated field test used to assess aerobic endurance and functional fitness, especially in older adults or people with chronic conditions (e.g., cardiopulmonary disease, neurological disorders).

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients being diagnosed with pulmonary hypertension (PH)

You may qualify if:

• Being diagnosed with pulmonary hypertension (PH)
• Being 18 years of age or older
• Agreeing to participate in the study

You may not qualify if:

• Acute decompensated heart failure
• Orthopedic or neurological disorders that prevent the test from being performed
• Patients who have difficulty understanding the instructions given

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

Istanbul University - Cerrahpasa

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hypertension, Pulmonary

Interventions

Exercise Test

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Physiotherapist, PhD

Study Record Dates

• First Submitted: September 17, 2025
• First Posted: September 25, 2025
• Study Start: September 15, 2025
• Primary Completion: June 15, 2026
• Study Completion (Estimated): June 25, 2026
• Last Updated: May 7, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)