MRI-Based Paraspinal Fatty Degeneration and Its Association With BMD and Sarcopenia

NCT07238777 | Completed

• 1 other identifier: Beylikdüzüstateh19
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This cross-sectional study aims to investigate the relationship between MRI-based paraspinal muscle fatty degeneration, bone mineral density (BMD), and sarcopenia parameters in postmenopausal women. A total of 100 participants aged 60-80 years will be included. Lumbar paraspinal fatty infiltration will be evaluated both qualitatively using the Goutallier classification and quantitatively using ImageJ software to calculate muscle area, fat area, fat ratio, and functional muscle area. BMD and T-scores of the lumbar spine (L1-L4) and femoral neck will be measured using dual-energy X-ray absorptiometry (DXA). Sarcopenia will be diagnosed based on EWGSOP2 criteria, including muscle mass (assessed by bioelectrical impedance analysis), handgrip strength, and physical performance tests (gait speed, SPPB, TUGT, and 5STS). Sarcopenia-specific quality of life will be assessed using the Sarcopenia Quality of Life Questionnaire (SarQoL-TR). The study aims to clarify the associations among paraspinal muscle quality, bone health, and sarcopenia, providing a comprehensive understanding of muscle-bone interactions in postmenopausal women. Findings may support the use of paraspinal muscle evaluation as a complementary marker in the management of sarcopenia and osteoporosis.

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (1)

• MRI-derived paraspinal fat ratio

  Evaluation of the association between MRI-derived paraspinal fat ratio and lumbar (L1-L4) and femoral neck BMD values measured by DXA.

  Baseline

Secondary Outcomes (6)

• Lumbar Bone Mineral Density (BMD)

  Baseline

• Lumbar T-Score

  Baseline

• Femoral Neck BMD

  Baseline

• Femoral Neck T-Score

  Baseline

• Sarcopenia-Specific Quality of Life (SarQoL) Total Score

  Baseline

Eligibility Criteria

• Age: 60 Years - 80 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

postmenopausal women aged 60-80 years

You may qualify if:

• Female participants aged 60-80 years
• Postmenopausal status
• Lumbar MRI and DXA scan performed within the past six months
• Willingness to participate and ability to provide written informed consent

You may not qualify if:

• History of lumbar spine surgery (e.g., laminectomy, stabilization)
• Pfirrmann grade ≥4 lumbar disc degeneration on MRI¹³
• Secondary osteoporosis or Paget's disease
• Use of walking aids or mobility restrictions
• Neurological or systemic disorders affecting movement, including:
• Parkinson's disease
• Stroke
• Amyotrophic lateral sclerosis (ALS)
• Central or peripheral vertigo
• Severe immobility or inability to complete performance tests
• Presence of a hip prosthesis

Sponsors & Collaborators

• Beylikduzu State Hospital: lead

Study Sites (1)

Beylikdüzü State Hospital

Istanbul, Beylikdüzü, 34147, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 16, 2025
• First Posted: November 20, 2025
• Study Start: April 20, 2025
• Primary Completion: June 10, 2025
• Study Completion: June 10, 2025
• Last Updated: November 20, 2025

Record last verified: 2025-11

Locations

TU (1)