Frailty and Assocciated Factors in Sarcopenia

NCT06931964 | Completed

• 1 other identifier: Karabuk 001
• Study Type: observational
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

Primary sarcopenia is a condition that occurs with the aging process and is characterized by symptoms such as decreased muscle mass, impaired muscle function and decreased physical strength. The decrease in muscle mass can lead to a decrease in physical strength, balance and mobility, making older people more prone to frailty and falls, which can lead to a fear of falling. Although there are few studies on sarcopenia in the literature, the level of frailty in sarcopenia is related to balance, falls risk and kinesiophobia in sarcopenia. Our aim in the study was to measure frailty in elderly individuals diagnosed with sarcopenia and to determine the level of frailty. to evaluate the effect of sarcopenia on fall risk, balance and kinesiophobia and to evaluate the effect of sarcopenia on fall risk, balance and kinesiophobia according to the results of the evaluation and new rehabilitation programs on frailty, falls, kinesiophobia and balance resulting from sarcopenia and to be the basic data for the programs to be created.

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (4)

• Frailty

  Frailty will be assessed with the Edmonton Frailty Scale. It is scored between 0-17. Frailty increases as the score increases. 0-4 points: Not frail, 5-6 points: Mildly frail, 7-8 points: Moderately frail, 9-17 points: Severely frail.

  Baseline

• Risk of falling

  Fall risk will be assessed with the Denn Fall Risk Assessment Scale. The total score is generally: 0-3: Low risk, 4-6: Medium risk, 7 and above: High risk.

  Baseline

• Kinesiophobia

  The Tampa Kinesiophobia Scale will be used to assess kinesiophobia. Total score: 17-68. Higher scores indicate greater kinesiophobia (fear of movement).

  Baseline

• Balance

  Balance will be assessed with a posturography device.

  Baseline

Study Arms (1)

Sarcopenia

According to EWGSOP2 criteria; individuals diagnosed with sarcopenia were included in the study by evaluating low muscle strength, low muscle quantity or quality, and low physical performance.

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with sarcopenia included in this study.

You may qualify if:

• Volunteering to participate in the study
• years of age or older
• Being diagnosed with primary sarcopenia by a specialist
• To have the cooperation to perform the measurements

You may not qualify if:

• Having a disease that will affect balance (vertigo etc.)
• Not volunteering to participate in the study
• History of trauma within the last six months (fracture, soft tissue injury, etc.)
• Having undergone lower extremity surgery

Sponsors & Collaborators

• Karabuk University: lead

Study Sites (1)

Karabük University

Karabük, 78000, Turkey (Türkiye)

Location

Related Publications (2)

• Ye L, Liang R, Liu X, Li J, Yue J, Zhang X. Frailty and sarcopenia: A bibliometric analysis of their association and potential targets for intervention. Ageing Res Rev. 2023 Dec;92:102111. doi: 10.1016/j.arr.2023.102111. Epub 2023 Oct 29.

  PMID: 38031836 BACKGROUND

• Alvarez-Bustos A, Carnicero-Carreno JA, Davies B, Garcia-Garcia FJ, Rodriguez-Artalejo F, Rodriguez-Manas L, Alonso-Bouzon C. Role of sarcopenia in the frailty transitions in older adults: a population-based cohort study. J Cachexia Sarcopenia Muscle. 2022 Oct;13(5):2352-2360. doi: 10.1002/jcsm.13055. Epub 2022 Jul 28.

  PMID: 35903871 RESULT

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Metehan Yana

  Karabuk University

  PRINCIPAL INVESTIGATOR

• Ecem Çoroğlu, BD

  Karabuk University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Supervisor, PhD

Study Record Dates

• First Submitted: February 11, 2025
• First Posted: April 17, 2025
• Study Start: June 1, 2024
• Primary Completion: May 20, 2025
• Study Completion: May 20, 2025
• Last Updated: July 16, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)