A Real World Study of Respiratory Critical Disease.
1 other identifier
observational
500
1 country
1
Brief Summary
Acute Respiratory Distress Syndrome (ARDS) is a form of acute diffuse lung injury caused by various etiologies, which rapidly progresses to acute respiratory failure. It is characterized by a sudden onset and severe clinical course. Globally, ARDS affects approximately 3 million individuals each year, accounting for about 10% of admissions to intensive care units (ICUs). Due to the lack of specific pharmacological therapies, mechanical ventilation remains the mainstay of treatment. Therefore, identifying and analyzing prognostic factors for ARDS patients is of great significance for improving patient outcomes and reducing the incidence of poor prognosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2019
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2019
CompletedFirst Submitted
Initial submission to the registry
June 13, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2025
CompletedFirst Posted
Study publicly available on registry
September 10, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2025
CompletedSeptember 10, 2025
September 1, 2025
6.4 years
June 13, 2025
September 2, 2025
Conditions
Outcome Measures
Primary Outcomes (2)
Mortality
Clinical observation
Day 28 after ARDS diagnosis
Mortality
Clinical observation
Day 60 after ARDS diagnosis
Secondary Outcomes (5)
Chest CT Scan
Monitored daily
Complete Blood Count
Monitored daily
Serial Arterial Blood Gas Monitoring
Monitored daily after enrollment
Fluid Input and Output Balance
Whenever fluid input or output occurs
Mechanical Ventilation Monitoring
Every second after intubation
Interventions
Obsercational study
Eligibility Criteria
Patients identified as high risk for ARDS after ICU admission.
You may qualify if:
- Patients with underlying diseases associated with high risk of ARDS, including but not limited to: sepsis, pneumonia, multiple trauma, pulmonary contusion, inhalation injury, massive blood transfusion, other high-risk conditions, or other factors causing excessive respiratory drive.
- Patients (or legal representatives) who have provided a signed and dated informed consent form.
You may not qualify if:
- Age under 18 years.
- HIV infection.
- Known immunodeficiency disorders (e.g., leukemia, common variable immunodeficiency, etc.).
- History of solid organ or bone marrow transplantation.
- Receiving treatment with G-CSF or GM-CSF.
- Patients with a decision to withdraw from active treatment.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ming Zhonglead
Study Sites (1)
Fudan University, Zhong Shan Hospital
Shanghai, Shanghai Municipality, 200032, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- PI
Study Record Dates
First Submitted
June 13, 2025
First Posted
September 10, 2025
Study Start
March 1, 2019
Primary Completion
July 31, 2025
Study Completion
December 31, 2025
Last Updated
September 10, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will share