Acute Kidney Injury and Recovery Mode in Pediatric Liver Transplantation

NCT06598228 | Completed DMC

• 1 other identifier: 20240903-1
• Study Type: observational
• Target: 700
• Locations: 1 country
• Sites: 1

Brief Summary

Acute kidney injury (AKI) is a common complication after pediatric liver transplantation (PLT), and renal impairment after LT has proven to be related with increased graft failure and mortality. The recovery mode of kidney injury after PLT has not been systematically studied. Therefore, in this study the investigators aimed to systematically evaluate prognosis of AKI after PLT, combine the recovery mode of AKI with related risk factors, and establish a relationship between AKI and CKD.

Conditions

Postoperative Acute Kidney Injury; Pediatric Liver Transplantation

Outcome Measures

Primary Outcomes (1)

• Graft survival

  Loss of graft is defined as patient death or secondary transplantation

  Based on the most recent follow-up before December 31, 2023. The investigators collected clinical data of patients from 2014 to 2018, and followed enrolled participants until at least 5 years after surgery

Study Arms (3)

the group without acute kidney injury

Patients not diagnosed with acute kidney injury according to KDIGO(Kidney Disease: Improving Global Outcomes) criteria

Other: No Intervention: Observational Cohort

the group with transient acute kidney injury

Patients diagnosed with acute kidney injury according to KDIGO(Kidney Disease: Improving Global Outcomes) criteria and recovered within 48h

Other: No Intervention: Observational Cohort

the group with persistent acute kidney injury

Patients diagnosed with acute kidney injury according to KDIGO(Kidney Disease: Improving Global Outcomes) criteria and sustained over 48h

Other: No Intervention: Observational Cohort

Interventions

No Intervention: Observational Cohort OTHER

no intervention

the group with persistent acute kidney injury; the group with transient acute kidney injury; the group without acute kidney injury

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This study was conducted on pediatric patients (aged ≤18 years) who received liver transplantation at Tianjin First Central Hospital in China between January 1, 2014 and December 31, 2018

You may qualify if:

• Patients who received a liver transplant for the first time.
• Patients who were younger than 18 years of age at the time of transplant.

You may not qualify if:

• Patients with incomplete clinical data.
• Patients with less than 5 years of follow-up.
• Patients who have combined multiple solid organ transplants.
• Patients with preoperative renal impairment (eGFR\<60ml/min/1.73 m2 or prior renal replacement therapy).

Sponsors & Collaborators

• Tianjin First Central Hospital: lead

Study Sites (1)

Tianjin First Central Hospital

Tianjin, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the pediatric organ transplant unit

Study Record Dates

• First Submitted: September 12, 2024
• First Posted: September 19, 2024
• Study Start: July 1, 2024
• Primary Completion: September 1, 2024
• Study Completion: September 1, 2024
• Last Updated: September 23, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)