Neural Respiratory Drive Combined With Pro-Brain Natriuretic Peptide (Pro-BNP) as Predictor of Deterioration After Lung Transplantation

NCT07525440 | Completed

• 2 other identifiers: YLS20242020B11111340009
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Lung transplantation has become a promising therapeutic option for various end-stage lung diseases. However, many factors such as infection, graft rejection, airway complications would cause deterioration and shorten the survival time. It is important to detect the deterioration early and receive treatment timely, which may enhance survival. We hypothesis the decreased neural respiratory drive(NRD) would be increased in the deterioration due to the aggravation of lung. Furthermore, pro-Brain Natriuretic Peptide(pro-BNP) has been reported to be associated with greater mortality after lung transplantation.For this reason, we investigated the NRD and pro-BNP before and after lung transplantation and during deterioration. 80 patients were recruited.They were end-stage lung disease patients admitted to hospital for lung transplantation. The NRD and pro-BNP were monitored before and after lung transplantation.we investigated the NRD and pro-BNP before and after lung transplantation and during deterioration.

Conditions

Lung Transplantation

Outcome Measures

Primary Outcomes (1)

• deterioration

  deterioration rate

  6 years

Study Arms (1)

the patients with end-stage lung diseases after lung transplantation

we investigated the NRD and pro-BNP before and after the patients with end-stage lung diseases lung transplantation and during deterioration. The relationship between NRD and pro-BNP and the deterioration were investigated

Other: No Intervention: Observational Cohort

Interventions

No Intervention: Observational Cohort OTHER

no intervention

the patients with end-stage lung diseases after lung transplantation

Eligibility Criteria

• Age: 20 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patients with end-stage lung diseases referral to lung transplantation. Including chronic obstructive pulmonary disease, interstitial lung disease, bronchiectasia

You may qualify if:

• The patients with end-stage lung diseases referral to lung transplantation,Including chronic obstructive pulmonary disease, interstitial lung disease, bronchiectasia

You may not qualify if:

• (1) Malignancy （2）Severe cardiovascular diseases （3）Neuromuscular and chest wall deformity (4) Cardiovascular instability (hypotension, arrhythmias, myocardial infarction) (5) Change in mental status; uncooperative patients （6）Renal failure and severe blood electrolyte disturbances

Sponsors & Collaborators

• The First Affiliated Hospital of Guangzhou Medical University: lead

Study Sites (1)

Unknown Facility

Guangzhou, 520120, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

signal of neural respiratory drive(NRD) and the result of pro-Brain Natriuretic Peptide(pro-BNP)

Study Officials

• jianheng zhang, MD

  State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 6, 2026
• First Posted: April 13, 2026
• Study Start: January 1, 2016
• Primary Completion: February 1, 2026
• Study Completion: February 1, 2026
• Last Updated: April 13, 2026

Record last verified: 2026-04

Locations

CN (1)