Hainan Community Cognition Cohort

NCT06686186 | Recruiting DMC

• 4 other identifiers: Hainan Medical UniversityZDYF2024SHFZ06482360673XRC2022005
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

This is a community-based prospective cohort study in Hainan Province, China. The study was initialized in 2023 and included older residents for longitudinal follow-up. The research aims to identify risk factors as well as health and social outcomes that are associated with cognitive impairment in elderly populations, and independently develop AI-assisted software and applications for cognitive enhancement and physical rehabilitation training.

Conditions

Cognitive Impairment; Dementia; Age Problems

Outcome Measures

Primary Outcomes (4)

• The prevalence and incidence of cognitive impairment base on the communities

  Mild cognitive impairment was measured using a Chinese version Mini-Mental State Examination, which was collected by questionnaire. The minimum value of the Mini-Mental State Examination is 0, and the maximum value is 30, the higher the score, the better the cognition outcome.

  An average of 1 to 2 years

• The prevalence and incidence of dementia using a population-based survey

  Dementia was determined by diagnosis of hospitalization or Clinical Dementia Rating Scale (Montreal Cognitive Assessment, MoCA). The minimum value of the MoCA is 0, and the maximum value is 30, the higher the score, the better the outcome. In addition, subtypes of dementia will be based on the specific clinical diagnosis.

  An average of 1 to 2 years

• The conversion rate of normal to cognitive impairment

  Percentage of enrolled population that convert from normal to cognitive impairment

  An average of 1 to 2 years

• The conversion rate of cognitive impairment to dementia

  Percentage of enrolled population that convert from cognitive impairment to dementia

  An average of 1 to 2 years

Interventions

No Intervention: Observational Cohort OTHER

There were no interventions in our cohort. The subjects of our cohort were and will be followed up at the regular intervals.

Eligibility Criteria

• Age: 60 Years - 120 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community residents aged 60 years or older in Hainan Province, China

You may qualify if:

• Age 60 years and above
• Lived in the community for more than 6 months
• Signed the informed consent form

You may not qualify if:

• Cannot complete the survey

Sponsors & Collaborators

• Hainan Medical College: lead
• The Second Affiliated Hospital of Hainan Medical University: collaborator
• Xuanwu Hospital, Beijing: collaborator
• Fudan University: collaborator

Study Sites (1)

Hainan Medical University

Haikou, Hainan, 571199, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Plan to collect blood samples from some participants

MeSH Terms

Conditions

Cognitive Dysfunction; Dementia

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Central Study Contacts

Jindong Ding Petersen, PHD.

CONTACT

089866893772; dingjindong@muhn.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 23, 2024
• First Posted: November 13, 2024
• Study Start: December 16, 2022
• Primary Completion (Estimated): December 31, 2053
• Study Completion (Estimated): December 31, 2053
• Last Updated: November 13, 2024

Record last verified: 2024-09

Locations

CN (1)