SAVE: School Ambassadors for Vaccine Education

NCT07164144 | Enrolling By Invitation

• 1 other identifier: STUDY00010895
• Study Type: interventional
• Target: 6,000
• Locations: 1 country
• Sites: 1

Brief Summary

Influenza is associated with millions of cases of school absenteeism due to illness, hundreds of hospitalizations and thousands of deaths in the U.S. each year, which can be greatly reduced with influenza vaccination. The goal of this randomized controlled trial is to learn if training school personnel in vaccine communication techniques and equipping schools with vaccine promotional materials targeting students and their parents/guardians increases the influenza vaccination rates of the student population within participating schools. The main question it aims to answer is:

• Will flu vaccination rates be higher in intervention schools compared to control schools by the end of the intervention period? Participating schools will:
• Have select school personnel (school nurses, coaches, teachers, etc.) complete an online training module and optional training workshop focused on vaccine communication \[intervention arm only\]
• Utilize vaccine promotional materials (posters, flyers, digital files for social media, etc.) provided by the study team during flu season \[intervention arm only\]
• Track student vaccination rates \[intervention + control arm\]

Conditions

Influenza Vaccination

Outcome Measures

Primary Outcomes (1)

• Flu vaccination rate

  8 months (one flu season August-March)

Study Arms (2)

Intervention

EXPERIMENTAL

Behavioral: Vaccine Communication Training

Control

NO INTERVENTION

Interventions

Vaccine Communication Training BEHAVIORAL

School personnel receive vaccine communication training + promotional materials

Intervention

Eligibility Criteria

• Age: 5 Years - 21 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• A student enrolled in a participating school (intervention or control) for at least two years

Sponsors & Collaborators

• University of Rochester: lead
• Centers for Disease Control and Prevention: collaborator

Study Sites (1)

Public Schools

Rochester, New York, 14614, United States

Location

MeSH Terms

Conditions

Influenza, Human

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Pediatrics & Division Chief, General Pediatrics

Study Record Dates

• First Submitted: August 27, 2025
• First Posted: September 9, 2025
• Study Start: April 1, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: March 5, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)