Ultrasound-Guided Subtransverse Interligamentary Block Versus Thoracic Paravertebral Block for Postoperative Analgesia in Patients Undergoing Open Nephrectomy

NCT07138794 | Completed

• 1 other identifier: 36264PR1283/7/25
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare ultrasound-guided subtransverse process interligamentary (STIL) block versus thoracic paravertebral block (TPVB) for postoperative analgesia in patients undergoing open nephrectomy.

Conditions

Thoracic Paravertebral Block; Postoperative Analgesia; Open Nephrectomy; Subtransverse Interligamentary Block

Outcome Measures

Primary Outcomes (1)

• Total morphine consumption

  Rescue analgesia of morphine will be given as 3 mg bolus if the numeric rating scale (NRS) \> 3 to be repeated after 30 min if pain persists until the NRS \< 4.

  48 hours postoperatively

Secondary Outcomes (6)

• Time to the 1st rescue analgesia

  48 hours postoperatively

• Intraoperative fentanyl consumption

  Intraoperatively

• Mean arterial pressure

  Till the end of surgery (Up to 2 hours)

• Heart rate

  Till the end of surgery (Up to 2 hours)

• Degree of pain

  48 hours postoperatively

Study Arms (2)

STIL group

EXPERIMENTAL

Patients will receive subtransverse process interligamentary (STIL) block using 20ml of bupivacaine 0.25%.

Other: Subtransverse process interligamentary

TPVB group

EXPERIMENTAL

Patients will receive a thoracic paravertebral block (TPVB) using 20ml of bupivacaine 0.25%.

Other: Thoracic paravertebral block

Interventions

Subtransverse process interligamentary OTHER

Patients will receive subtransverse process interligamentary (STIL) block using 20ml of bupivacaine 0.25%.

STIL group

Thoracic paravertebral block OTHER

Patients will receive a thoracic paravertebral block (TPVB) using 20ml of bupivacaine 0.25%.

TPVB group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age from 18 to 65 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-III.
• Undergoing open nephrectomy under general anesthesia.

You may not qualify if:

• History of allergies to local anesthetics.
• Opioid dependency.
• Bleeding or coagulation disorders.
• Psychiatric and neurological disorder.
• Local infection at the site of injection.
• Body mass index (BMI) \> 35 kg/m2.
• Severe heart, lung, liver, and renal dysfunction.
• Pregnant or lactating women.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: August 17, 2025
• First Posted: August 24, 2025
• Study Start: August 23, 2025
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)