Transversus Thoracic Muscle Plane Block, Erector Spinae Plane Block and Paravertebral Block for Analgesia in Video-Assisted Thoracic Surgery

NCT06987136 | Completed

• 1 other identifier: 36264PR1184/4/25.
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare the transversus thoracic muscle plane block (TTPB), erector spinae plane block (ESPB), and thoracic paravertebral block (TPVB) for postoperative analgesia in patients undergoing video-assisted thoracoscopic surgery (VATS).

Conditions

Transversus Thoracic Muscle Plane Block; Erector Spinae Plane Block; Paravertebral Block; Analgesia; Video-Assisted Thoracic Surgery

Outcome Measures

Primary Outcomes (1)

• Time to the 1st rescue analgesia

  Time to the first request for the rescue analgesia (time from end of surgery to first dose of morphine administrated).

  24 hours postoperatively

Secondary Outcomes (6)

• Total morphine consumption

  24 hours postoperatively

• Degree of pain

  24 hours postoperatively

• Heart rate

  Till the end of surgery (Up to 2 hours)

• Mean arterial pressure

  Till the end of surgery (Up to 2 hours)

• Degree of patient satisfaction

  24 hours postoperatively

Study Arms (3)

Transversus thoracic muscle plane block group

EXPERIMENTAL

Patients will receive a transversus thoracic muscle plane block.

Other: Transversus thoracic muscle plane block

Erector spinae plane block group

EXPERIMENTAL

Patients will receive an erector spinae plane block.

Other: Erector spinae plane block

Thoracic paravertebral block group

EXPERIMENTAL

Patients will receive a thoracic paravertebral block.

Other: Thoracic paravertebral block

Interventions

Transversus thoracic muscle plane block OTHER

Patients will receive a transversus thoracic muscle plane block.

Transversus thoracic muscle plane block group

Erector spinae plane block OTHER

Patients will receive an erector spinae plane block.

Erector spinae plane block group

Thoracic paravertebral block OTHER

Patients will receive a thoracic paravertebral block.

Thoracic paravertebral block group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.
• Scheduled for video-assisted thoracic surgery under general anesthesia.

You may not qualify if:

• Body mass index \>30 kg/m2.
• Coagulopathy.
• History of opiate abuse.
• Pre-existing chronic pain.
• Allergy to local anesthetics or analgesics.
• Infection at the site of injection.
• Mental or neurological disorders.
• Operation converted to open thoracotomy.
• Renal dysfunction (glomerular filtration rate (GFR) \< 50 ml/min).
• Pregnancy

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

MeSH Terms

Conditions

Agnosia

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt

Study Record Dates

• First Submitted: May 15, 2025
• First Posted: May 23, 2025
• Study Start: May 24, 2025
• Primary Completion: November 8, 2025
• Study Completion: November 8, 2025
• Last Updated: November 25, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)