Relationship Between Thyroid Dysfunction and Diabetes

NCT07099937 | Not Yet Recruiting

• 1 other identifier: thyroid and diabetes mellitus
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

Evaluate the expression of glycemic parameters, lipid profile, and thyroid hormones in patients with type 2 diabetes mellitus in upper egypt.

Conditions

Type 2 Diabetes Mellitus (T2DM); Thyroid Dysfunction; Metabolic Syndrome; Upper Egypt Patients

Outcome Measures

Primary Outcomes (2)

• Prevalence of thyroid dysfunction among type 2 diabetic patients

  The outcome will measure the proportion (%) of type 2 diabetic patients diagnosed with thyroid dysfunction. This includes classification into hypothyroidism, hyperthyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism based on standard laboratory cutoffs of TSH, free T3, and free T4.

  Baseline

• Association between thyroid dysfunction and metabolic syndrome in type 2 diabetic patients

  The outcome will assess the statistical correlation (e.g., chi-square test or logistic regression) between the presence of thyroid dysfunction and the diagnosis of metabolic syndrome, according to IDF criteria. Results will be reported as odds ratios or p-values as appropriate.

  Baseline

Interventions

Observational cross-sectional study with no intervention. OTHER

This study does not involve any intervention. It is a cross-sectional observational study. The term "intervention" here refers to laboratory investigations and clinical assessments conducted as part of data collection only.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 18 years and above diagnosed with type 2 diabetes mellitus attending the Diabetes and Endocrinology Outpatient Clinic at Assiut University Hospitals, Upper Egypt.

You may qualify if:

• Patients diagnosed with type 2 diabetes mellitus in upper egypt.
• Age above 18 years.
• Patients who gave informed consent to participate.

You may not qualify if:

• Patients with type 1 diabetes mellitus.
• Age below 18 years.
• Patients with known autoimmune thyroid diseases, pregnancy, or acute illness at the time of assessment.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Sakamoto M. Type 2 Diabetes and Glycemic Variability: Various Parameters in Clinical Practice. J Clin Med Res. 2018 Oct;10(10):737-742. doi: 10.14740/jocmr3556w. Epub 2018 Sep 10.

  PMID: 30214644 BACKGROUND

• Ford ES, Li C, Sattar N. Metabolic syndrome and incident diabetes: current state of the evidence. Diabetes Care. 2008 Sep;31(9):1898-904. doi: 10.2337/dc08-0423. Epub 2008 Jun 30.

  PMID: 18591398 BACKGROUND

• Hadgu R, Worede A, Ambachew S. Prevalence of thyroid dysfunction and associated factors among adult type 2 diabetes mellitus patients, 2000-2022: a systematic review and meta-analysis. Syst Rev. 2024 Apr 30;13(1):119. doi: 10.1186/s13643-024-02527-y.

  PMID: 38689302 BACKGROUND

• Chen H, Wu J, Lyu R. Expressions of glycemic parameters, lipid profile, and thyroid hormone in patients with type 2 diabetes mellitus and their correlation. Immun Inflamm Dis. 2024 Jul;12(7):e1282. doi: 10.1002/iid3.1282.

  PMID: 38967365 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Metabolic Syndrome

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Insulin Resistance; Hyperinsulinism

Central Study Contacts

Ghada Ragab Hamed Abdelnasser, M.B.B.Ch

CONTACT

+20 1281862140; Ghada.17289947@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: July 18, 2025
• First Posted: August 1, 2025
• Study Start: September 1, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: August 1, 2025

Record last verified: 2025-07