Metabolic Syndrome in Patients with Knee Osteoarthritis

NCT06611774 | Not Yet Recruiting

• 1 other identifier: osteoarthritis MetSyndrome
• Study Type: observational
• Target: 174
• Locations: 0 countries
• Sites: N/A

Brief Summary

Study the prevalence of metabolic syndrome in patients with knee osteoarthritis and conclude the relationship between metabolic syndrome and the severity of knee osteoarthritis

Conditions

Knee Osteoarthritis; Metabolic Syndrome

Keywords

knee osteoarthritis; metabolic syndrome

Outcome Measures

Primary Outcomes (1)

• Metabolic syndrome in patients with knee osteoarthritis

  Study the prevalence of metabolic syndrome in patients with knee osteoarthritis and the relation between metabolic syndrome and clinical, functional, radiological finding of knee osteoarthritis

  Baseline

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted in assiut university hospitals and presenting to its clinics

You may qualify if:

• Both males and female .
• Age between 30 and 70 years old.
• Patient fulfill the criteria of knee osteoarthritis .

You may not qualify if:

• Patients known to have rheumatological disease .
• Patients with meniscal or cruciate ligament injury .
• Patients with previous knee surgery .

Sponsors & Collaborators

• Assiut University: lead

Related Publications (6)

• Maddah S, Mahdizadeh J. Association of Metabolic Syndrome and Its Components with Knee Osteoarthritis. Acta Med Iran. 2015 Dec;53(12):743-8.

  PMID: 26749230 BACKGROUND

• Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010 Aug;26(3):355-69. doi: 10.1016/j.cger.2010.03.001.

  PMID: 20699159 BACKGROUND

• Goldring SR, Goldring MB. Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk. Nat Rev Rheumatol. 2016 Nov;12(11):632-644. doi: 10.1038/nrrheum.2016.148. Epub 2016 Sep 22.

  PMID: 27652499 BACKGROUND

• Xie DX, Wei J, Zeng C, Yang T, Li H, Wang YL, Long HZ, Wu ZY, Qian YX, Li KH, Lei GH. Association between metabolic syndrome and knee osteoarthritis: a cross-sectional study. BMC Musculoskelet Disord. 2017 Dec 16;18(1):533. doi: 10.1186/s12891-017-1890-9.

  PMID: 29246142 BACKGROUND

• Courties A, Sellam J. Osteoarthritis and type 2 diabetes mellitus: What are the links? Diabetes Res Clin Pract. 2016 Dec;122:198-206. doi: 10.1016/j.diabres.2016.10.021. Epub 2016 Nov 5.

  PMID: 27889689 BACKGROUND

• Tu C, He J, Wu B, Wang W, Li Z. An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis. Cytokine. 2019 Jan;113:1-12. doi: 10.1016/j.cyto.2018.06.019. Epub 2018 Jun 28.

  PMID: 30539776 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee; Metabolic Syndrome

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Fady Kerollos Louis, Dr

CONTACT

01207936730; Fadykeros5@gmail.com

Salwa Salaheldin Elgendi, professor

CONTACT

01005766155; Salwaelgendi@yahoo.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant lecturer

Study Record Dates

• First Submitted: August 9, 2024
• First Posted: September 25, 2024
• Study Start: October 1, 2024
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): February 1, 2027
• Last Updated: September 25, 2024

Record last verified: 2024-09