Thyroid Dysfunction in Patients With Major Psychiatric Disorders

NCT06293534 | Not Yet Recruiting

• 1 other identifier: PsychThyroid
• Study Type: observational
• Target: 173
• Locations: 0 countries
• Sites: N/A

Brief Summary

Thyroid dysfunction in major psychiatric disorders in psychiatric patients admitted to psychiatric unit of assiut university hospital

Conditions

Thyroid Dysfunction

Outcome Measures

Primary Outcomes (1)

• the level of thyroid hormones among psychiatric patients

  TSH, free T3 and free T4 levels in psychiatric patients.

  One year

Study Arms (1)

Patients with major psychiatric disorders

Patients diagnosed with major psychiatric disorders according to the Diagnostic Statistical Manual version 5 (DSM 5-TR), admitted to the psychiatry department in Assiut University Hospital.

Diagnostic Test: TSH,T3,T4

Interventions

TSH,T3,T4 DIAGNOSTIC_TEST

Diagnosis of the psychiatric disorders among study group will be assessed and recorded and history of Electroconvulsive therapy (ECT) also will be recorded , physical examination for signs that suggests actual thyroid disease such as unexplained bradycardia or tachycardia, hypothermia , goiter or non palpable thyroid among study group will be assessed

Patients with major psychiatric disorders

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with mental illness, diagnosed based on DSM 5-TR and whose condition is severe enough to require admission in the psychiatric ward.

You may qualify if:

• patients with major psychiatric disorders admitted to psychiatric unit of neuropsychiatry department of Assiut university hospital in Egypt.

You may not qualify if:

• pregnant or lactating females
• Patients on estrogen therapy or contraceptive
• Patients on carbamazepine, oxcarbazepine, phenytoin

Sponsors & Collaborators

• Assiut University: lead

Related Publications (6)

• Kamble MT, Nandedkar PD, Dharme PV, L LS, Bhosale PG. Thyroid function and mental disorders: an insight into the complex interaction. J Clin Diagn Res. 2013 Jan;7(1):11-4. doi: 10.7860/JCDR/2012/4861.2656. Epub 2013 Jan 1.

  PMID: 23449617 BACKGROUND

• Lekurwale V, Acharya S, Shukla S, Kumar S. Neuropsychiatric Manifestations of Thyroid Diseases. Cureus. 2023 Jan 20;15(1):e33987. doi: 10.7759/cureus.33987. eCollection 2023 Jan.

  PMID: 36811059 BACKGROUND

• Dickerman AL, Barnhill JW. Abnormal thyroid function tests in psychiatric patients: a red herring? Am J Psychiatry. 2012 Feb;169(2):127-33. doi: 10.1176/appi.ajp.2011.11040631.

  PMID: 22318794 BACKGROUND

• Lederbogen F, Hermann D, Hewer W, Henn FA. Thyroid function test abnormalities in newly admitted psychiatric patients residing in an iodine-deficient area: patterns and clinical significance. Acta Psychiatr Scand. 2001 Oct;104(4):305-10. doi: 10.1034/j.1600-0447.2001.00328.x.

  PMID: 11722306 BACKGROUND

• Radhakrishnan R, Calvin S, Singh JK, Thomas B, Srinivasan K. Thyroid dysfunction in major psychiatric disorders in a hospital based sample. Indian J Med Res. 2013 Dec;138(6):888-93.

  PMID: 24521631 BACKGROUND

• Fukao A, Takamatsu J, Arishima T, Tanaka M, Kawai T, Okamoto Y, Miyauchi A, Imagawa A. Graves' disease and mental disorders. J Clin Transl Endocrinol. 2019 Oct 11;19:100207. doi: 10.1016/j.jcte.2019.100207. eCollection 2020 Mar.

  PMID: 31763175 BACKGROUND

Study Officials

• Ghada Abdelrahman mohamed, M.D.

  Assiut University

  STUDY DIRECTOR

• Rania Mohamed Mahmoud Hafez, M.D.

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Marwa M Abdelsalam

CONTACT

+201018987436; marwamahmouud.97@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: December 13, 2023
• First Posted: March 5, 2024
• Study Start: March 1, 2024
• Primary Completion: January 1, 2025
• Study Completion: February 1, 2025
• Last Updated: March 5, 2024

Record last verified: 2024-02