NCT00283673

Brief Summary

This study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. Several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
102

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 1995

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1995

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 1998

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 1998

Completed
8.1 years until next milestone

First Submitted

Initial submission to the registry

January 27, 2006

Completed
3 days until next milestone

First Posted

Study publicly available on registry

January 30, 2006

Completed
Last Updated

June 6, 2011

Status Verified

June 1, 2011

Enrollment Period

2.3 years

First QC Date

January 27, 2006

Last Update Submit

June 3, 2011

Conditions

Aging

Outcome Measures

Primary Outcomes (1)

  • Insulin sensitivity

Secondary Outcomes (3)

  • Muscle Mitochondrial Protein Synthesis

  • mRNA of mitochondrial genes

  • mRNA of genes involved in mitochondrial biogenesis

Interventions

ExerciseBEHAVIORAL

Eligibility Criteria

Age20 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Healthy subjects performing \< 30 min exercise twice per week. Age 20-90 years. Willing to be randomized to exercise versus no exercise. Willing to be studied in General Clinical Research Center with studies including Muscle Biopsy.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

Related Publications (1)

  • Short KR, Vittone JL, Bigelow ML, Proctor DN, Rizza RA, Coenen-Schimke JM, Nair KS. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes. 2003 Aug;52(8):1888-96. doi: 10.2337/diabetes.52.8.1888.

    PMID: 12882902RESULT

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • K. Sreekumaran Nair, M.D.

    Mayo Clinic

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 27, 2006

First Posted

January 30, 2006

Study Start

September 1, 1995

Primary Completion

January 1, 1998

Study Completion

January 1, 1998

Last Updated

June 6, 2011

Record last verified: 2011-06

Locations

US(1)