Ultrasound Guided Quadratus Lumborum Block, Thoracolumbar Interfascial Plane Block, and Local Anesthetic Infiltration for Lumbar Spine Fixation

NCT07448987 | Completed

• 1 other identifier: 36264MS646/7/24
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to compare the efficacy of ultrasound guided trans-muscular quadratus lumborum Block, thoracolumbar interfascial plane block and local anesthetic infiltration for elective lumbar spine fixation undergo up to three-level fixation.

Conditions

Quadratus Lumborum Block; Thoracolumbar Interfascial Plane Block; Local Anesthetic Infiltration; Lumbar Spine Fixation

Outcome Measures

Primary Outcomes (1)

• Total morphine consumption

  Intravenous morphine (0.05mg/kg) was given when numeric rating scale (NRS) equal or above 4.

  24 hours postoperatively

Secondary Outcomes (4)

• Mean arterial pressure

  Till end of surgery (Up to 2 hours)

• Heart rate

  Till end of surgery (Up to 2 hours)

• Time to the first request for rescue analgesia

  24 hours postoperatively

• Degree of pain

  24 hours postoperatively

Study Arms (3)

Group I: QLB group

EXPERIMENTAL

Patients received general anesthesia and bilateral ultrasound guided trans-muscular quadratus lumborum block (QLB 3) with (20 ml Bupivacaine 0.25% each side) + (Dexmedetomidine 0.5 mic/kg) for each side as total volume (1 mic/kg).

Other: Quadratus lumborum block

Group II: TLIP block group

EXPERIMENTAL

Patients received general anesthesia and bilateral ultrasound guided thoracolumbar interfascial plane block with (20ml of Bupivacaine 0.25%) for each side + (Dexmedetomidine 0.5 mic/kg) for each side as total volume (1 mic/kg).

Other: Thoracolumbar interfascial plane block

Group III: Local wound infiltration group

EXPERIMENTAL

Patients received general anesthesia and local anesthetic infiltration at the side of incision before with (40 ml of Bupivacaine 0.25%) + (Dexmedetomidine 1mic/kg).

Other: Local anesthetic infiltration

Interventions

Quadratus lumborum block OTHER

Patients received general anesthesia and bilateral ultrasound guided trans-muscular quadratus lumborum block (QLB 3) with (20 ml Bupivacaine 0.25% each side) + (Dexmedetomidine 0.5 mic/kg) for each side as total volume (1 mic/kg).

Group I: QLB group

Thoracolumbar interfascial plane block OTHER

Patients received general anesthesia and bilateral ultrasound guided thoracolumbar interfascial plane block with (20ml of Bupivacaine 0.25%) for each side + (Dexmedetomidine 0.5 mic/kg) for each side as total volume (1 mic/kg).

Group II: TLIP block group

Local anesthetic infiltration OTHER

Patients received general anesthesia and local anesthetic infiltration at the side of incision before with (40 ml of Bupivacaine 0.25%) + (Dexmedetomidine 1mic/kg).

Group III: Local wound infiltration group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age from 18 to 65 years.
• Both genders.
• American Society of Anesthesiology (ASA) class I - II.
• Scheduled for elective lumbar spine fixation up to three level.

You may not qualify if:

• Patient refusal.
• History of allergy to local anesthetic.
• Mental dysfunction or cognitive disorders.
• Body Mass Index \> 30 kg/m2.
• Coagulopathy.
• Pregnancy.
• Infections to the site of the block.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Anesthesia, Surgical Intensive Care and Pain Management, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: February 26, 2026
• First Posted: March 4, 2026
• Study Start: July 1, 2024
• Primary Completion: August 30, 2025
• Study Completion: August 30, 2025
• Last Updated: March 4, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)