Is The Level of Muscle Damage After The Drop Jump Protocol Affected By Body Weight and BMI?

NCT07046598 | Completed DMC

• 1 other identifier: SakaryaAppliedSciencesU
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigated whether muscle damage induced by a drop jump protocol varies based on participants' body weight and BMI. Fifty healthy adults were divided into normal-weight and overweight groups. All participants completed a standardized drop jump protocol, and blood samples were collected before, immediately after, and 24 hours after exercise. Creatine kinase (CK) and lactate dehydrogenase (LDH) levels were analyzed as biomarkers of muscle damage.

Conditions

Body Mass Index; Physical Exertion; Muscle Damage; Creatine Kinase; Lactate Dehydrogenases

Keywords

drop jump; muscle damage; creatine kinase; lactate dehydrogenase; body mass index; plyometric exercise

Outcome Measures

Primary Outcomes (2)

• Change in Creatine Kinase (CK) Levels

  Serum creatine kinase (CK) concentrations measured at three time points: before the exercise protocol, immediately after the protocol, and 24 hours post-exercise. CK is a biomarker of muscle damage. Blood samples were analyzed using a standard biochemical analyzer.

  Baseline (pre-exercise), immediately post-exercise, and 24 hours post-exercise

• Change in Lactate Dehydrogenase (LDH) Levels

  Serum lactate dehydrogenase (LDH) concentrations measured at three time points: before the exercise protocol, immediately after the protocol, and 24 hours post-exercise. LDH is used to evaluate exercise-induced muscle damage. Blood samples were centrifuged and analyzed using standardized laboratory techniques.

  Baseline (pre-exercise), immediately post-exercise, and 24 hours post-exercise

Study Arms (2)

Normal Weight Group

EXPERIMENTAL

Participants with a Body Mass Index (BMI) between 18 and 24 kg/m². Subjects in this group performed a standardized drop jump (DJ) protocol consisting of 100 total jumps from a 60 cm platform. Muscle damage markers (Creatine Kinase and Lactate Dehydrogenase) were measured pre-exercise, immediately post-exercise, and 24 hours post-exercise.

Behavioral: Drop Jump Protocol

Overweight Group

EXPERIMENTAL

Participants with a Body Mass Index (BMI) between 25 and 35 kg/m². Subjects in this group performed the same standardized drop jump (DJ) protocol as the normal weight group. Blood samples were collected at three time points to evaluate changes in muscle damage markers (Creatine Kinase and Lactate Dehydrogenase).

Behavioral: Drop Jump Protocol

Interventions

Drop Jump Protocol BEHAVIORAL

A standardized drop jump (DJ) protocol involving 100 total jumps from a 60 cm platform. Participants performed five sets of 20 jumps, with a 10-second rest between jumps and a 2-minute rest between sets. The protocol was designed to induce muscle damage through eccentric loading.

Normal Weight Group; Overweight Group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults aged 18-30
• Normal or overweight BMI (18-35 kg/m²)
• At least 2 days/week of physical activity
• No regular jump training

You may not qualify if:

• Use of medications or supplements
• History of musculoskeletal injury
• Smoking or alcohol consumption during study period

Sponsors & Collaborators

• Melike Nur Eroğlu: lead

Study Sites (1)

Sakarya University of Applied Sciences, Faculty of Sport Sciences, Exercise and Sports Sciences Education, Application and Research Centre

Serdivan, Sakarya, Turkey (Türkiye)

Location

Related Publications (1)

• Yeniyol B, Pancar S, Soylu Y, Birinci YZ, Eroglu MN, Fernandez-Elias VE. The overlooked risk in drop jump protocols: higher body weight as a catalyst for increased muscle damage. BMC Sports Sci Med Rehabil. 2025 Sep 29;17(1):278. doi: 10.1186/s13102-025-01330-z.

  PMID: 41024229 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: June 14, 2025
• First Posted: July 1, 2025
• Study Start: October 15, 2024
• Primary Completion: November 8, 2024
• Study Completion: November 22, 2024
• Last Updated: July 1, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)