Serum CPK and Creatinine Changes During Plyometric Training in Collegiate Athletes

NCT07356193 | Completed

• 1 other identifier: BMC-CPK-Study-2023
• Study Type: interventional
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study evaluated the effects of an eight-week lower body plyometric training program on serum creatine phosphokinase (CPK) and creatinine levels in male collegiate volleyball players. Sixty two players were divided into experimental and control groups. CPK and creatinine were measured at baseline and multiple time points during training. The study assessed whether plyometric training produced harmful biochemical changes or signs of rhabdomyolysis.

Conditions

Plyometric Exercises; Creatine Kinase; Exercise Physiology; Muscle Damage

Keywords

Plyometric Training; Volleyball Players; Creatine Phosphokinase; Serum Creatinine

Outcome Measures

Primary Outcomes (1)

• Serum Creatine Phosphokinase (CPK) Levels

  Change in serum CPK measured using the CK-NAC optimized IFCC method.

  Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8

Secondary Outcomes (1)

• Serum Creatinine Levels

  Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8

Study Arms (2)

Lower Body Plyometric Training

EXPERIMENTAL

Behavioral: Lower Body Plyometric Training; Other: control group

Control Group

ACTIVE COMPARATOR

Other: control group

Interventions

Lower Body Plyometric Training BEHAVIORAL

Training twice weekly for eight weeks, including low-, moderate-, and high-intensity plyometric exercises (squat jumps, box jumps, tuck jumps, split squat jumps, lateral hurdle jumps, zigzag jumps, single-leg tuck jumps, and depth jumps).

Lower Body Plyometric Training

control group OTHER

Routine volleyball training only; no plyometric exercises.

Control Group; Lower Body Plyometric Training

Eligibility Criteria

• Age: 18 Years - 20 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• male collegiate volleyball players
• Age: 18-20 years
• No prior plyometric training

You may not qualify if:

• History of kidney disease
• Current musculoskeletal injury
• neuromuscular impairments

Sponsors & Collaborators

• Batterjee Medical College: lead

Study Sites (1)

Batterjee Medical College

Jeddah, Saudi Arabia

Location

MeSH Terms

Interventions

Control Groups

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 11, 2026
• First Posted: January 21, 2026
• Study Start: February 13, 2022
• Primary Completion: August 10, 2022
• Study Completion: December 28, 2022
• Last Updated: January 22, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)