Accuracy of Venous Excess Ultrasound Score at Hospital Admission to Predict Acute Kidney Injury

NCT07040696 | Recruiting

• 1 other identifier: VEXUS score in preeclampsia
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate diagnostic accuracy of venous excess ultrasound score to predict acute kidney injury

Conditions

Preeclampsia; Acute Kidney Injury

Keywords

preeclampsia; VEXUS score; AKI

Outcome Measures

Primary Outcomes (1)

• The accuracy of VEXUS score at admission to predict acute kidney injury

  within 48 hours of admission

Secondary Outcomes (3)

• need for renal replacement therapy

  at 28 days of admission

• Cumulative fluid balance

  within 48 hours of admission

• In hospital mortality

  At 28 days of admission

Study Arms (1)

Preeclampsia with severe features

Features of severity will be defined according to American college of obstetric and gynacology guidelines

Device: Venous excess ultrasound score (VEXUS)

Interventions

Venous excess ultrasound score (VEXUS) DEVICE

Doppler examination of inferior vena cave, portal vein, hepatic vein, and intrarenal vein will be conducted by an experienced operator

Preeclampsia with severe features

Eligibility Criteria

• Age: 20 Years - 40 Years
• Gender Eligibility Details: Preeclampsia with severe features is defined according to the American College of Obstetricians and Gynecologists (ACOG)
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

preeclampsia with severe features

You may qualify if:

• preeclampsia with severe features

You may not qualify if:

• Patient refusal
• Preexisting renal impairment (defined as baseline serum creatinine \> 1.3 mg/dl)
• Inability to obtain adequate Doppler views
• Renal transplantation
• Previous need for renal replacement therapy
• Known peripheral vascular disease

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, Giza Governorate, 6890, Egypt

RECRUITING

Related Publications (4)

• Viana-Rojas JA, Argaiz E, Robles-Ledesma M, Arias-Mendoza A, Najera-Rojas NA, Alonso-Bringas AP, De Los Rios-Arce LF, Armenta-Rodriguez J, Gopar-Nieto R, Briseno-De la Cruz JL, Gonzalez-Pacheco H, Sierra-Lara Martinez D, Gonzalez-Salido J, Lopez-Gil S, Araiza-Garaygordobil D. Venous excess ultrasound score and acute kidney injury in patients with acute coronary syndrome. Eur Heart J Acute Cardiovasc Care. 2023 Jul 7;12(7):413-419. doi: 10.1093/ehjacc/zuad048.

  PMID: 37154067 BACKGROUND

• Rola P, Miralles-Aguiar F, Argaiz E, Beaubien-Souligny W, Haycock K, Karimov T, Dinh VA, Spiegel R. Clinical applications of the venous excess ultrasound (VExUS) score: conceptual review and case series. Ultrasound J. 2021 Jun 19;13(1):32. doi: 10.1186/s13089-021-00232-8.

  PMID: 34146184 BACKGROUND

• Naqvi R, Hossain N, Butt S, Bhellar Z, Fatima E, Imtiaz S, Moosa PG, Abbas K, Jafri SB, Khan S. Efficacy of multiple Biomarkers: NGAL, KIM1, Cystatin C and IL18 in predicting pregnancy related acute kidney injury. Pak J Med Sci. 2023 Jan-Feb;39(1):34-40. doi: 10.12669/pjms.39.1.6930.

  PMID: 36694779 BACKGROUND

• Hassan M, Mayanja R, Ssalongo WGM, Robert N, Mark LH, Samson O, Muhindo R. Incidence and predictors of acute kidney injury among women with severe pre-eclampsia at Mbarara Regional Referral Hospital. BMC Nephrol. 2022 Nov 2;23(1):353. doi: 10.1186/s12882-022-02972-8.

  PMID: 36324072 BACKGROUND

MeSH Terms

Conditions

Pre-Eclampsia; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

cairo university

CONTACT

+201275716942; kasralainirec@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of anesthesia

Study Record Dates

• First Submitted: June 18, 2025
• First Posted: June 27, 2025
• Study Start: June 22, 2025
• Primary Completion: December 30, 2025
• Study Completion: December 31, 2025
• Last Updated: July 2, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)