Transition of Acute Kidney Injury to Chronic Kidney Disease

NCT04101110 | Completed

• 1 other identifier: EROT
• Study Type: observational
• Target: 252
• Locations: 1 country
• Sites: 1

Brief Summary

Acute kidney injury is a complex clinical syndrome,associated with high short and long- term morbidity and mortality in critical ill patients.Acute kidney injury outcomes may vary from a complete resolution to a partial or incomplete recovery of renal function leading to increased mortality,prolonged hospitalization and risk of chronic comorbidities . The precise mechanism of acute kidney injury to chronic kidney disease transition is complex and not completely understood,especially in humans .Acute kidney injury outcomes depend upon the balance of adaptive and maladaptive repair.

Conditions

Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

• Incidence of chronic kidney disease

  Incidence of chronic kidney disease defined by a decreased glomerular filtration rate under 60 mL/minute/1.73m2

  Baseline

Interventions

Renal biopsy OTHER

Kidney biopsy will be done to understand the nature and degree of structural kidney damage

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients attending Assiut university hospitals critical care unit and developing acute kidney injury during their stay.

You may qualify if:

• patients ≥18 years;
• patients suffering an acute kidney injury (defined by Acute kidney injury network (AKIN) score ≥1)during ICU stay.

You may not qualify if:

• patients \<18 years;
• pregnant woman;
• End stage renal disease (ESRD)prior to ICU admission;
• Refusal to participate in the study.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut university hospitals

Asyut, Egypt

Location

Related Publications (4)

• Sileanu FE, Murugan R, Lucko N, Clermont G, Kane-Gill SL, Handler SM, Kellum JA. AKI in low-risk versus high-risk patients in intensive care. Clin J Am Soc Nephrol. 2015 Feb 6;10(2):187-96. doi: 10.2215/CJN.03200314. Epub 2014 Nov 25.

  PMID: 25424992 RESULT

• Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, Honore PM, Joannes-Boyau O, Joannidis M, Korhonen AM, Lavrentieva A, Mehta RL, Palevsky P, Roessler E, Ronco C, Uchino S, Vazquez JA, Vidal Andrade E, Webb S, Kellum JA. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015 Aug;41(8):1411-23. doi: 10.1007/s00134-015-3934-7. Epub 2015 Jul 11.

  PMID: 26162677 RESULT

• Singbartl K, Kellum JA. AKI in the ICU: definition, epidemiology, risk stratification, and outcomes. Kidney Int. 2012 May;81(9):819-25. doi: 10.1038/ki.2011.339. Epub 2011 Oct 5.

  PMID: 21975865 RESULT

• Goldstein SL, Chawla L, Ronco C, Kellum JA. Renal recovery. Crit Care. 2014 Jan 6;18(1):301. doi: 10.1186/cc13180.

  PMID: 24393370 RESULT

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prinsipal Investigator

Study Record Dates

• First Submitted: September 19, 2019
• First Posted: September 24, 2019
• Study Start: April 1, 2021
• Primary Completion: September 1, 2021
• Study Completion: December 1, 2022
• Last Updated: July 27, 2023

Record last verified: 2020-07

Locations

EG (1)